NANOVACCINE

作品数：33被引量：65H指数：4
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相关领域：医药卫生更多>>
相关作者：李艳梅更多>>
相关机构：清华大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Science China Chemistry》《Asian Journal of Pharmaceutical Sciences》《Frontiers of Materials Science》更多>>
相关基金：国家自然科学基金中国博士后科学基金天津市自然科学基金国家重点基础研究发展计划更多>>
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Turning foes to friends:Advanced“in situ nanovaccine”with dual immunoregulation for enhanced immunotherapy of metastatic triple-negative breast cancer被引量：1
《Bioactive Materials》2024年第9期612-629,共18页Ze Wang Tong Sha Jinwei Li Huanyu Luo Annan Liu Hao Liang Jinbiao Qiang Lei Li Andrew K.Whittaker Bai Yang Hongchen Sun Ce Shi Quan Lin 
supported by the National Key Research and Development Program of China(2022YFC2504200);the National Natural Science Foundation of China(Nos.82270959 and 81970903);the Natural Science Foundation of Jilin Province(No.SKL202302002);the Key Research and Development Project of Jilin Provincial Science and Technology Department(Nos.20210204142YY);the Jilin University Norman Bethune Program(No.2023B28);the Fundamental Research Funds for the Central Universities,the Natural Science Foundation of Liaoning Province(No.2022-BS-123);the Science and Technology Project of Shenyang(No.21-173-9-34);“Medical+X”Interdisciplinary Innovation Team“Announcement and Leadership”Construction Project(2022JBGS08).
As a“cold tumor”,triple-negative breast cancer(TNBC)exhibits limited responsiveness to current immunotherapy.How to enhance the immunogenicity and reverse the immunosuppressive microenvironment of TNBC remain a form...
关键词：Metastatic triple-negative breast cancer In situ nanovaccine Immunogenic cell death Dual immunoregulation Synergistic therapy 
An emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria
《Science Bulletin》2024年第16期2565-2579,共15页Linfu Chen Zheyu Kang Jingjing Shen Rui Zhao Yu Miao Lin Zhang Zixuan Zheng Zhemin Zhang Nanhui Liu Cheng Wang Huapan Fang Jun Zhou Yudong Wang Zhuang Liu Yang Yang Qian Chen 
partially supported by the National Research Programs of China(2022YFA1206500 and 2020YFA0211100);the National Natural Science Foundation of China(52172285 and 52325106);the Suzhou Key Laboratory of Nanotechnology and Biomedicine,the Collaborative Innovation Centre of Suzhou Nano Science and Technology;the 111 Program from the Ministry of Education of China.
Fusobacterium nucleatum(F.nucleatum),an oral anaerobe,is prevalent in colorectal cancer and is closely related to increased cancer cell growth,metastasis,and poor treatment outcomes.Bacterial vaccines capable of selec...
关键词：Fusobacterium nucleatum Bacterial vaccine Colorectal cancer Biomimetic nanomedicine CHEMOTHERAPY 
An antigen self-assembled and dendritic cell-targeted nanovaccine for enhanced immunity against cancer被引量：2
《Acta Pharmaceutica Sinica B》2023年第8期3518-3534,共17页Yunting Zhang Min Jiangy Guangsheng Du Xiaofang Zhong Chunting He Ming Qin Yingying Hou Rong Liu Xun Sun 
financially supported by the National Natural Science Foundation of China(81925036&81872814);the Key Research and Development Program of Science and Technology Department of Sichuan Province(2020YFS0570,China);Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System(CARS-SVDIP);111 project(b18035,China);the Fundamental Research Funds for the Central Universities(China)。
The rise of nanotechnology has opened new horizons for cancer immunotherapy.However,most nano vaccines fabricated with nanomaterials suffer from carrier-related concerns,including low drug loading capacity,unpredictab...
关键词：Subunit antigen Self-assembled nanovaccine Dendritic cell Mannose receptor Zoledronic acid Antigen cross-presentation Cellular immunity Cancer immunotherapy 
Ionizable polymeric nanocarriers for the codelivery of bi-adjuvant and neoantigens in combination tumor immunotherapy被引量：1
《Bioactive Materials》2023年第8期169-180,共12页Ting Su Xiang Liu Shuibin Lin Furong Cheng Guizhi Zhu 
G.Z.acknowledges funding support from NIH(R01CA266981,R01AI168684,R35GM143014,R21NS114455);DoD CDMRP Breast Cancer Breakthrough Award Level II(BC210931/P1);NIH-NCATS KL2 scholarship(KL2TR002648)via VCU C.Kenneth and Dianne Wright Center for Clinical and Translational Research(UL1TR002649);American Cancer Society Research Scholar Grant(RSG-22-055-01-IBCD);METAvivor Early Career Investigator Award,among others.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.T.S.and F.C.acknowledge the National Natural Science Foundation of China(52103199,82102203);Guangdong Basic and Applied Basic Research Foundation(2020A1515110811).
Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines.Here,we report ionizable polymeric nanoparticles that co-deliver bi-adjuvant and neoantigen peptides for cancer immunotherapy in...
关键词：Polymeric nanoparticles Combination adjuvants Cancer neoantigen Nanovaccine codelivery Cancer immunotherapy 
Mucosal delivery of nanovaccine strategy against COVID-19 and its variants被引量：1
《Acta Pharmaceutica Sinica B》2023年第7期2897-2925,共29页Junwoo Lee Dongwoo Khang 
supported by grants from the National Research Foundation of Korea(2019R1A2C1085986,2022M3A9H1014123,2022M3A9G8018189)。
Despite the global administration of approved COVID-19 vaccines(e.g.,ChAdOx1 nCoV-19?,mRNA-1273?,BNT162b2?),the number of infections and fatalities continue to rise at an alarming rate because of the new variants such...
关键词：COVID-19 Vaccine platforms Mucosal vaccine Mucosa-associated lymphoid tissue(MALT) Microfold cell(M cell) Dendritic cell(DC) Polymeric nanoparticleLiposome 
A tetrahedral framework nucleic acid based multifunctional nanocapsule for tumor prophylactic mRNA vaccination被引量：2
《Chinese Chemical Letters》2023年第7期169-175,共7页Yuhao Liu Songhang Li Shiyu Lin Sirong Shi Taoran Tian Bowen Zhang Tao Zhang Yunfeng Lin 
supported by National Key R&D Program of China (No. 2019YFA0110600);National Natural Science Foundation of China (No. 81970916);Sichuan Province Youth Science and Technology Innovation Team (No. 2022JDTD0021);Research Funding from West China School/Hospital of Stomatology Sichuan University (No. RCDWJS2021-20);China Postdoctoral Science Foundation (No. 2022TQ0381)。
Synthetic antigen-encoding mRNA plays an increasingly significant role in tumor vaccine technology owing to its antigen-specific immune-activation. However, its immune efficacy is challenged by inferior delivery effic...
关键词：Tetrahedral framework nucleic acid(tFNA) RNA nanovaccine Cytosine-phosphate-guanine(CpG)motifs Murineβ-defensin 2(mDF2β) Tumor immunotherapy 
Ovalbumin-loaded paramagnetic nano-triangles for enhanced dendritic cell stimulation,T_(1)-MR imaging,and antitumor immunity
《Journal of Materials Science & Technology》2023年第17期123-137,共15页Yike Hou Zhe Tang Jabeen Farheen Madiha Saeed Lijia Luo Wenzi Ren Dandan Luo Asim Mushtaq Ruibo Zhao Jian Ge Zhangsen Yu Yao Li M.Zubair Iqbal Xiangdong Kong 
financially supported by the National Natural Science Foundation of China(No.51672250 and 51902289);the Zhejiang International Science and Technology Cooperation Project(Nos.2021C01180 and 2019C04020);the Research Foundation of ZSTU(No.18012134-Y).
Vaccine-based cancer immunotherapy has demonstrated a significant potential for cancer treatment in clinics.Although the efficiencies of vaccines are limited,they can be enhanced by a well-designed antigen delivery sy...
关键词：OVALBUMIN NANOVACCINE Antigen delivery Magnetic resonance imaging Contrast agent Cancer immunotherapy 
Self-assembled multiepitope nanovaccine based on NoV P particles induces effective and lasting protection against H3N2 influenza virus
《Nano Research》2023年第5期7337-7346,共10页Jiaojiao Nie Qingyu Wang Shenghui Jin Xin Yao Lipeng Xu Yaotian Chang Fan Ding Zeyu Li Lulu Sun Yuhua Shi Yaming Shan 
the Department of Science and Technology of Jilin Province(Nos.20220204008YY and 20210204197YY);Changchun Science and Technology Bureau(No.21ZY15).
Current seasonal influenza vaccines confer only limited coverage of virus strains due to the frequent genetic and antigenic variability of influenza virus(IV).Epitope vaccines that accurately target conserved domains ...
关键词：SELF-ASSEMBLE norovirus protruding(NoV P)particle influenza virus multiepitope NANOVACCINE 
CD47KO/CRT dual-bioengineered cell membrane-coated nanovaccine combined with anti-PD-L1 antibody for boosting tumor immunotherapy被引量：5
《Bioactive Materials》2023年第4期211-224,共14页Shengyang Liu Jiayan Wu Yuanji Feng Xiaoya Guo Tong Li Meng Meng Jie Chen Daquan Chen Huayu Tian 
The authors are thankful to the National Key R&D Program of China(2021YFB3800900);National Natural Science Foundation of China(51925305,51873208,51973217);Taishan Scholar Foundation of Shandong Province(qnts20161035);Natural Science Foundation of Shandong Province(ZR2019ZD24,ZR2019YQ30);Jilin Province Science and Technology Development Program(20200201075JC,20210509005RQ).
Tumor vaccines trigger tumor-specific immune responses to prevent or treat tumors by activating the hosts’immune systems,and therefore,these vaccines have potential clinical applications.However,the low immunogenicit...
关键词：CRISPR-Cas9 Dual-bioengineered cell membrane Immune checkpoint blockade NANOVACCINE Tumor immunotherapy 
Nanomedicine sheds new light on cancer immunotherapy
《Medical Review》2023年第2期188-192,共5页Yingying Yu Liangzhu Feng Zhuang Liu 
Cancer immunotherapy comprising of immune checkpoint blockade(ICB)therapy,immune cell therapies,cancer vaccines and many others represents a profound arsenal in the fight against different types of cancers.However,the...
关键词：cancer immunotherapy in situ cancer vaccine NANOMEDICINE NANOVACCINE tumor microenvironment 
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