HYPOTHALAMIC

作品数：98被引量：124H指数：6
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Single-cell and spatial omics:exploring hypothalamic heterogeneity
《Neural Regeneration Research》2025年第6期1525-1540,共16页Muhammad Junaid Eun Jeong Lee Su Bin Lim 
supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI);the Ministry of Health&Welfare,Republic of Korea (HR22C1734);the National Research Foundation (NRF) of Korea (2020R1A6A1A03043539,2020M3A9D8037604,2022R1C1C1004756)(to SBL);the NRF of Korea (2022R1C1C1005741 and RS-2023-00217595);the new faculty research fund of Ajou University School of Medicine (to EJL)。
Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technolo...
关键词：cellular diversity HYPOTHALAMUS multi-omics single-cell transcriptomics spatial transcriptomics 
Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus
《Neural Regeneration Research》2025年第4期1098-1100,共3页Jae-Hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho Suk 
supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(2017R1A5A2015391 and 2020M3E5D9079764)(to KS).
Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s lifespan.The astrocytic regulation of neuronal activity has been increasingly recognized in recent years.Astroc...
关键词：SLEEP ventrolateral ASTROCYTES 
Electroacupuncture: A promising solution for obesity-induced reproductive dysfunction in male rats
《Natural Therapy Advances》2025年第1期22-35,共14页Jing-Yi Zhang Jun-Long Zhu Kun Zhu Xiao-Peng Huang Yao-Dong You Dong-Dong Yang De-Gui Chang Yi-Feng Shen 
supported by the Natural Science Foundation of Sichuan Province(2023NSFSC1799);the Science and Technology Development Fund of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine(23YY07);National Natural Science Foundation of China(82405413).
Background:Obesity represents a major public health issue,closely linked to a range of metabolic and reproductive disorders.Electroacupuncture(EA)has emerged as a potential non-pharmacological intervention that may al...
关键词：ELECTROACUPUNCTURE hypothalamic inflammation OBESITY leptin/kisspeptin signaling male rats 
Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity
《Cell Research》2025年第3期165-185,共21页Ling-Qi Xie Biao Hu Ren-Bin Lu Ya-Lun Cheng Xin Chen Jie Wen Yao Xiao Yu-Ze An Ning Peng Yu Dai Genqing Xie Qi Guo Hui Peng Xiang-Hang Luo 
supported by the National Natural Science Foundation of China(92149306,82120108009,81930022,82270911,82201746,82430028);Projects of International Cooperation and Exchanges NSFC(82120108009);Major Project of Natural Science Foundation of Hunan Province(Open Competition)(2021JC0002);the Scientific Research Program of FuRong Laboratory(2024PT5104).
Sleep deficiency is associated with obesity,but the mechanisms underlying this connection remain unclear.Here,we identify a sleep-inducible hypothalamic protein hormone in humans and mice that suppresses obesity.This ...
关键词：sleep induced hypothalamic hormone raptin OBESITY sleep deficiency RETICULOCALBIN sleep deficien suprachiasmatic nucleus vasopressin expressing neurons 
Effects of grain intervention on hypothalamic function and the metabolome of blood and milk in dairy cows
《Journal of Animal Science and Biotechnology》2024年第6期2543-2552,共10页Limei Lin Kaizhen Guo Huiting Ma Jiyou Zhang Zheng Lai Weiyun Zhu Shengyong Mao 
funded by Natural Science Foundation of China(32072755)。
Background The hypothalamus plays a crucial role in the health and productivity of dairy cows,yet studies on its fun ctionality and its impact on peripheral circulation in these animals are relatively scarce,particula...
关键词：BLOOD Grain-based diet HYPOTHALAMUS Metabolomics MILK Prostaglandin E_(2) TRANSCRIPTOMICS 
The effects of hypothalamic microglial activation on ventricular arrhythmias in stress cardiomyopathy
《Journal of Geriatric Cardiology》2024年第12期1119-1132,共14页Peng-Qi LIN Quan-Wei PEI Bin LI Jie-Mei YANG Li-Na ZOU De-Zhan SU Jun-Pei ZHANG Hong-Peng YIN Mbabazi Nadine Jun-Jie YANG Nevzorova Vera A Khan Musawir Abbas Zhao-Lei JIANG Jing-Jie LI De-Chun YIN 
supported by the National Natural Science Foundation of China(No.82270320);the Postdoctoral Scientific Research Developmental Found(LBHQ21155);the Distinguished Young Foundations of the First Affiliated Hospital of Harbin Medical University(HYD2020JQ002);the Science Foundation of the First Affiliated Hospital of Harbin Medical University(No.2018 L001).
Background Stress cardiomyopathy(SCM)currently has a high incidence in older adults,and the theories regarding its causes include“catecholamine myocardial toxicity”and“sympathetic hyperactivation”.However,the role...
关键词：CARDIOMYOPATHY VENTRICULAR ACTIVATION 
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
《Bone Research》2024年第4期1009-1030,共22页Wenkai Shao Bo Wang Ping Wang Shuo Zhang Song Gong Xiaodong Guo Deyu Duan Zengwu Shao Weijian Liu Lei He Fei Gao Xiao Lv Yong Feng 
supported by the National Natural Science Foundation of China (82472439,82270935,81974337,82102627);the Hubei Provincial Natural Science Foundation of China (2021CFB095);the Wuhan Knowledge Innovation Project (2022020801020468);the Project of Scientific Research Plan of Wuhan Municipal Health Commission (WX21Q19)。
Osteonecrosis of the femoral head(ONFH)is a common complication of glucocorticoid(GC)therapy.Recent advances demonstrate that sympathetic nerves regulate bone homeostasis,and GCs lower the sympathetic tone.Here,we sho...
关键词：SYMPATHETIC GLUCOCORTICOID FEMORAL 
Oxytocinergic Control of a Hypothalamic Social Fear Circuitry
《Neuroscience Bulletin》2024年第9期1399-1401,共3页Junqiang Zheng Xingying Wu Han Xu 
National Natural Science Foundation of China(32125018 and 32071005);Zhejiang Provincial Natural Science Foundation of China(LD24H090002);National Key Research and Development Program of China(2021YFA1101701);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2023-PT310-01);Nanhu Brain-computer Interface Institute(010904008);MOE Frontiers Science Center for Brain Science&Brain-Machine Integration of Zhejiang University.
Exhibiting appropriate social behavior toward conspecifics is crucial for survival within a social group.For instance,after a conflict,it is essential for the loser to stay away from the victor to avoid further harm[1...
关键词：MEDIAL HYPOTHALAMUS PRECISE 
Hypothalamic circuits and aging:keeping the circadian clock updated被引量：1
《Neural Regeneration Research》2024年第9期1919-1928,共10页Rosa Vázquez-Lizarraga Lucia Mendoza-Viveros Carolina Cid-Castro Sareni Ruiz-Montoya Erick Carreño-Vázquez Ricardo Orozco-Solis 
supported by National Council of Science and Technology(CONACYT)(grants FC 2016/2672 and FOSISS 272757),INMEGEN(09/2017/I);the Ministry of Education,Science,Technology and Innovation of Mexico City(SECTEI)(grant 228/2021).
Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of life.Studies on aged animal models have un...
关键词：AGING ASTROCYTES cellular stress responses circadian clock HYPOTHALAMUS intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis 
Effects of acupuncture on hypothalamic–pituitary–adrenal axis:Current status and future perspectives被引量：1
《Journal of Integrative Medicine》2024年第4期445-458,共14页Jia-yuan Zheng Jing Zhu Yu Wang Zhan-zhuang Tian 
supported by the National Natural Science Foundation of China (No. 81973639 and 81573712);the Innovative Research Team of High-level Local Universities in Shanghai;Shanghai Key Laboratory for Acupuncture Mechanism and Acupoint Function (No. 21DZ2271800)。
The hypothalamic–pituitary–adrenal(HPA) axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes. Dysre...
关键词：ACUPUNCTURE ELECTROACUPUNCTURE Hypothalamic-pituitary-adrenal axis Mechanism NEUROTRANSMITTER MICRORNA 
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