Effects of acupuncture on hypothalamic–pituitary–adrenal axis:Current status and future perspectives  

作　　者：Jia-yuan Zheng Jing Zhu Yu Wang Zhan-zhuang Tian 

机构地区：[1]Department of Integrative Medicine and Neurobiology,School of Basic Medical Sciences,State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science,Institutes of Brain Science,Institute of Acupuncture Research,Academy of Integrative Medicine,Shanghai Key Laboratory for Acupuncture Mechanism and Acupoint Function,Shanghai Medical College,Fudan University,Shanghai 200032,China [2]Department of Human Anatomy,School of Integrative Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

出　　处：《Journal of Integrative Medicine》2024年第4期445-458,共14页结合医学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 81973639 and 81573712);the Innovative Research Team of High-level Local Universities in Shanghai;Shanghai Key Laboratory for Acupuncture Mechanism and Acupoint Function (No. 21DZ2271800)。

摘　　要：The hypothalamic–pituitary–adrenal(HPA) axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes. Dysregulation of HPA axis function disrupts the neuroendocrine equilibrium, resulting in impaired physiological functions. Acupuncture is recognized as a non-pharmacological type of therapy which has been confirmed to play an important role in modulating the HPA axis and thus favorably targets diseases with abnormal activation of the HPA axis. With numerous studies reporting the promising efficacy of acupuncture for neuroendocrine disorders, a comprehensive review in terms of the underlying molecular mechanism for acupuncture, especially in regulating the HPA axis, is currently in need. This review fills the need and summarizes recent breakthroughs, from the basic principles and the pathological changes of HPA axis dysfunction, to the molecular mechanisms by which acupuncture regulates the HPA axis. These mechanisms include the modulation of multiple neurotransmitters and their receptors, neuropeptides and their receptors, and microRNAs in the paraventricular nucleus,hippocampus, amygdala and pituitary gland, which alleviate the hyperfunctioning of the HPA axis.This review comprehensively summarizes the mechanism of acupuncture in regulating HPA axis dysfunction for the first time, providing new targets and prospects for further exploration of acupuncture.

关 键 词：ACUPUNCTURE ELECTROACUPUNCTURE Hypothalamic-pituitary-adrenal axis Mechanism NEUROTRANSMITTER MICRORNA 

分 类 号：R245[医药卫生—针灸推拿学]