supported by the Foundation of Chongqing Talents(grant no.CQYC2021059825).
Purpose:To investigate the pathological changes of the synovium in mice with post-traumatic osteoarthritis(PTOA)treated with 4-octyl itaconate(4-OI)and evaluate the therapeutic effects of 4-OI.Methods:In the phenotypi...
Supported by The National Natural Science Foundation of China,No.82074246.
BACKGROUND Synovitis,acne,pustulosis,hyperostosis,and osteitis(SAPHO)syndrome,a rare inflammatory disease,was described in 1987 by Chamot et al,who identified its common characteristics and transitional forms through ...
This work was supported by the grants from the National Natural Science Foundation of China(Nos.82072425,81873991,and 81672238);the Program of Jiangsu Science and Technology Department(Nos.BK20211083 and BE2022737);the Program of Suzhou Health Commission(Nos.GSWS2020078 and SZXK202111);the Program of Suzhou Science and Technology Department(No.SKY2023062);the Jiangsu Graduate Student Cultivation Innovative Engineering Graduate Research and Practice Innovation Program(No.SJCX23_0683).
Synovial inflammation plays a key role in osteoarthritis(OA)pathogenesis.Fibroblast-like synoviocytes(FLSs)represent a distinct cell subpopulation within the synovium,and their unique phenotypic alterations are consid...
Introduction: Joint manifestations are common in systemic lupus, affecting multiple joints or just one. These manifestations are present in 95% of patients. Pseudo-septic arthritis is a subset of systemic lupus that m...
supported by Shineway Pharmaceutical Group Ltd.(No.2020110031006073).
Objective:Huamaoyan Granules(HMYG)and Huamaoyan Capsules(HMYC)are Chinese patent medicines with different dosage forms of the same prescription.Due to the different preparation process,the chemical composition of thes...
This work was supported by the grants from the Top Talent of Changzhou“The 14th Five-Year Plan”High-Level Health Talents Training Project,the Program of Jiangsu Science and Technology Department(Nos.BK20211083 and BE2022737);the Suzhou Municipal Health Commission(No.SKJY2021115);Jiangsu Medical Research Project(No.ZD2022021);the Special Project of Diagnosis and Treatment Technology for Key Clinical Diseases in Suzhou(No.LCZX202003);the Program of Suzhou Health Commission(Nos.GSWS2020078,GSWS2022002,and SZXK202111);the Suzhou Health Commission Science Education and Health Youth Project(No.KJXW2021040).
Osteoarthritis(OA)is a prevalent and chronic joint disease that affects the aging population,causing pain and disability.Macrophages in synovium are important mediators of synovial inflammatory activity and pathologic...
the Key Research and Development Projects of Anhui Province in 2022 under grant 202204c06020034;West Anhui University Outstanding Top Talent Training Project under grant gxgnfx 2019026;Anhui Undergraduate Quality Engineering Project under grant 2020szsfkc0908 and 2021jyxm1663;West Anhui University 2020 College Students’Innovation and Entrepreneurship Training Program(national level)under grant 202010376053;the Key Collaborative Research Program of the Alliance of International Science Organizations(Grant No.ANSO-CR-KP-2021-10)。
Objective:The purpose was to observe the anti-inflammatory effects of Dendrobium huoshanense polysaccharides(DHPs)on carrageenan-induced sterile air pouch synovitis.Materials and Methods:A total of 30 Institute of Can...
supported by grants from the National Natural Science Foundation of China(Grant Nos.81772406,81974341,81991511,81625015,and 81902268);the Natural Science Foundation of Guangdong Province(2020A1515010207 and 2022A1515010431);the China Postdoctoral Science Foundation(2019M663264 and 2019TQ0385).
Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been ex...
supported by the National Science Foundation of China(NSFC 81802196,81572129,81872877,91853109,and 81772335);Key Program of NSFC(81730067,China);Special Program of Chinese Academy of Science(XDA16020805,China);Jiangsu Provincial Key Medical Center Foundation(China);Jiangsu Provincial Medical Outstanding Talent Foundation(China);Jiangsu Provincial Key Medical Talent Foundation(China)。
Osteoarthritis(OA),in which M1 macrophage polarization in the synovium exacerbates disease progression,is a major cause of cartilage degeneration and functional disabilities.Therapeutic strategies of OA designed to in...
The study was financially supported by the Project of New Technology and New Business of Nanfang Hospital,Southern Medical University(No.2016018).
Objective Contrast-enhanced ultrasound(CEUS)is advantageous for evaluating microcirculation,and has been applied to assess arthritis in previous studies.However,CEUS examinations have not been studied for hemophilia a...