NF-KB

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双酚A加剧缺硒诱导鸡气管细胞焦亡的机制研究
《山东畜牧兽医》2025年第1期16-20,共5页樊明言 
为探究双酚A(BPA)和缺硒对鸡气管细胞焦亡的影响及其机制,本研究采用实验动物模型,评估BPA暴露与硒缺乏对鸡气管组织的细胞焦亡情况,使用分子生物学技术分析相关信号通路。结果显示,硒缺乏和BPA暴露均显著增加鸡气管细胞的焦亡现象,相...
关键词:硒缺乏 双酚A 细胞焦亡 鸡气管 NF-KB/NLRP3 
miR-155 induces sepsis-associated damage to the intestinal mucosal barrier via sirtuin 1/nuclear factor-κB-mediated intestinal pyroptosis
《Acta Biochimica et Biophysica Sinica》2024年第11期1618-1632,共15页Zhihua Li Yi Wang Weiwei Huang Xingyu Shi Tao Ma Xiangyou Yu 
This work was supported by the grant from the National Natural Science Foundation of China(No.82160360).
Sepsis is a life-threatening state of organ dysfunction caused by systemic inflammation and a dysfunctional response to host infections that can induce severe intestinal mucosal damage.Pyroptosis is mediated by the ac...
关键词:intestinal barrier dysfunction MIR-155 NF-KB PYROPTOSIS SEPSIS SIRT1 
电针预处理通过抑制NF-kB/NLRP3信号通路介导炎症和凋亡改善大鼠脑卒中后痉挛
《南方医科大学学报》2024年第11期2102-2109,共8页孙秀颀 蔡静 张安邦 庞博 陈春艳 查琪琪 全菲 叶涛 
国家自然科学基金(82060896);贵州省科技计划基础研究(科学技术基金)项目(黔科合基础-ZK[2021]一般505);贵州省教育厅青年科技人才成长项目(黔教合KY字[2021]210);贵州省中医药管理局中医药、民族医药科学技术研究课题(QZYY-2021-015);贵州省卫生健康委科学技术基金项目(gzwkj2021-072)。
目的探讨电针预处理诱导NF-κB/NLRP3信号通路及炎症和凋亡在脑卒中后挛治疗中的潜在机制。方法SPF级雄性SD大鼠18只随机分为:假手术组(sham),模型组(I/R),电针治疗组(I/R+EP),每组6只。假手术组仅暴露不做阻塞,模型组进行中动脉闭塞模...
关键词:脑卒中后痉挛 电针预处理 NF-κB/NLRP3信号通路 炎症反应 细胞凋亡 
连朴饮加味方对多重耐药Hp感染诱导人GES-1细胞凋亡及炎症抑制的影响
《时珍国医国药》2024年第11期2552-2558,共7页黄超群 吕文亮 苏成霞 许丹 胡运莲 毛宁锋 周姝含 张新悦 张洋 
武汉市卫生健康委员会科研计划资助项目(WZ21A04);武汉市科学技术局曙光计划资助项目(2022020801020584);湖北省科学技术厅自然科学基金资助项目(2023AFB347);湖北省中医药管理局资助项目(ZY2023F004);湖北中医药大学“双一流”建设重点类专项科研项目(2023ZZXJB003)。
目的探讨连朴饮加味方(以下简称连朴饮方)抑制多重耐药幽门螺杆菌(Helicobacter pylori,Hp)感染诱导人胃黏膜上皮GES-1细胞凋亡及炎症的关系,旨在阐明连朴饮方治疗耐药Hp胃炎的作用机制。方法实验分为空白组、模型组、连朴饮组、四联疗...
关键词:连朴饮加味方 幽门螺杆菌 耐药 炎症 NF-kB信号通道 
Narciclasine induces colon carcinoma cell apoptosis by inhibiting the IL-17A/Act1/TRAF6/NF-kB signaling pathway
《Genes & Diseases》2024年第5期428-441,共14页Huiming Deng Qiang Liu Siman Yu Lifan Zhong Lianfang Gan Huiquan Gu Qianru Wang Ruxin Cheng Yong Liu Li Liu Ling Huang Ronghua Xu 
the Shenzhen Science and Technology Plan(No.JCYJ20220530142009021);the National Natural Science Foundation of China(No.82060678,82060851,81760674);the Nanshan District of Shenzhen Science and Technology Project(China)(No.2019057).
IL-17 A is a promoter of colorectal cancer initiation and progression.Narciclasine is a polyhydroxy alkaloid compound isolated from Narcissus plants,which has potent anti-inflammatory and antitumor actions.The effects...
关键词:Act1 Apoptosis Colonrectal cancer IL-17A NARCICLASINE NF-KB 
探讨MIAT通过NF-KB/IL-6/STAT3通路影响心梗后交感神经重构
《哈尔滨医药》2024年第5期1-6,共6页郑劲松 范伟 李文礼 蓝雄师 钟志钦 刘远新 刘珊 何利伟 彭健 
广东省医学科学技术研究基金项目(B2021316)。
目的探讨MIAT通过NF-KB/IL-6/STAT3通路对MI后交感神经重构的影响,为临床MI后心源性猝死防治提供新的理论依据和治疗靶点。方法选取SPF级雄性Sprague-Dawley(SD)大鼠24只,根据实验需求随机分为Sham组、AMI组、AMI+shMIAT组和AMI+shCont...
关键词:MIAT NF-KB/IL-6/STAT3通路 AMI 交感神经重构 
Suppression of NFATc1 through NF-kB/PI3K signaling pathway by Oleandrin to inhibit osteoclastogenesis and bone resorption
《Engineered Regeneration》2024年第3期342-349,共8页Zhikun Li Kai Chen Qifeng Yu Yifan Li Shichao Tong Ruijun Xu Ruixi Hu Yi Zhang Wei Xu 
National Natural Science Foundation of China(82272165);Shanghai Municipal Commission of Health and Family Planning’s Science and Research Fund(202040141);Shanghai Municipality Science and Technology Commission(20ZR1451800,22ZR1457200);Shanghai Municipal Health Commission(2022YQ006);Shanghai Tongren Hospital(TRKYRC-xx202203).
Inflammation can initiate osteolysis,which is the breakdown of bone by fully developed osteoclasts.The com-pound Oleandrin is recognized for its effects against inflammation and tumors.Our objective was to examine the...
关键词:OSTEOCLASTOGENESIS OSTEOLYSIS NF-κB PI3K Oleandrin NFATc1 
Proanthocyanidins isolated from lotus seed skin mitigate glycolipid metabolism disorder through the p38/Nrf2/NF-κB signaling pathway
《Acta Biochimica et Biophysica Sinica》2024年第9期1300-1310,共11页Yuhang Yi Tao Li Chenghao Lv Wenjiang He Wenzhi Li Xixin Zhou Si Qin 
supported by the grants from the National Key Research and Development Program of China(No.2019YFC1604903);the Hunan Natural Science Foundation(No.2023JJ30295 to S.Q.).
Lotus seed skin extract is rich in flavonoids,making it a promising candidate for developing health products.In a previous study,we found that proanthocyanidins from lotus seed skin,particularly proanthocyanidin B1(PB...
关键词:PROANTHOCYANIDINS lotus seed skin p38/Nrf2/NF-kB glycolipid metabolism 
Uncovering the impact of alcohol on internal organs and reproductive health:Exploring TLR4/NF-kB and CYP2E1/ROS/Nrf2 pathways
《Animal Models and Experimental Medicine》2024年第4期444-459,共16页Eason Qi Zheng Kong Vetriselvan Subramaniyan Natasha Sura Anak Lubau 
supported by the Jeffrey Cheah School of Medicine and Health Sciences and the Library Resources,Monash University Malaysia
This review delves into the detrimental impact of alcohol consumption on internal organs and reproductive health,elucidating the underlying mechanisms involving the Toll-like receptor 4(TLR4)/Nuclear factor kappa ligh...
关键词:ALCOHOL health impact inflammation metabolism molecular pathways 
Epinephrine promotes tumor progression and M2 polarization of tumor-associated macrophages by regulating the TRIM2-NF-kB pathway in colorectal cancer cells
《Genes & Diseases》2024年第4期141-144,共4页Zhengyi Liu Chenxing Jian Wenzheng Yuan Guiqing jia Donghui cheng Yanzhuo Liu Yanling Zhang Bin Zhang Zili Zhou Gaoping Zhao 
supported by the National Natural Science Foundation of China(No.81902435);Natural Science Foundation of Fujian Province of China(No.2021J011371);Sichuan Science and Technology Program of China(No.2021YFS0375,2023NSFSC1899);Science and technology project of Henan Province,China(No.222102310037);Henan Province Medical Science and Technology Project of China(No.LHGJ20220018);Medjaden Academy&Research Foundation for Young Scientists(China)(No.MJR20221014);Project of Sichuan Provincial People's Hospital(China)(No.2022QN03,2021LY14).
Tumor-associated inflammation is an important component of the tumor microenvironment,and an important factor affecting tumor progression.In the tumor microenvironment,tumor-associated macrophages(TAMs)receive differe...
关键词:NEPHRIN tumor inflammation 
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