Epinephrine promotes tumor progression and M2 polarization of tumor-associated macrophages by regulating the TRIM2-NF-kB pathway in colorectal cancer cells  

作　　者：Zhengyi Liu Chenxing Jian Wenzheng Yuan Guiqing jia Donghui cheng Yanzhuo Liu Yanling Zhang Bin Zhang Zili Zhou Gaoping Zhao 

机构地区：[1]Department of Breast Surgery,Henan Provincial People's Hospital,The People's Hospital of Zhengzhou University,The People's Hospital of Henan University,Zhengzhou,Henan 450003,China [2]Microbiome Laboratory,Henan Provincia People's Hospital Zhengzhou University People's Hospital,Zhengzhou,Henan 450000,China [3]Department of Gastrointestinal Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China [4]Department of Gastrointestinal Surgeryll,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China [5]Department of Gastrointestinal Surgery,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China [6]Department of Hepatobiliary Surgery,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China

出　　处：《Genes & Diseases》2024年第4期141-144,共4页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.81902435);Natural Science Foundation of Fujian Province of China(No.2021J011371);Sichuan Science and Technology Program of China(No.2021YFS0375,2023NSFSC1899);Science and technology project of Henan Province,China(No.222102310037);Henan Province Medical Science and Technology Project of China(No.LHGJ20220018);Medjaden Academy&Research Foundation for Young Scientists(China)(No.MJR20221014);Project of Sichuan Provincial People's Hospital(China)(No.2022QN03,2021LY14).

摘　　要：Tumor-associated inflammation is an important component of the tumor microenvironment,and an important factor affecting tumor progression.In the tumor microenvironment,tumor-associated macrophages(TAMs)receive different stimuli and can be polarized into classically activated M1 macrophages and alternatively activated M2 macrophages.Many studies have indicated that the polarization of TAMs is closely related to tumor progression.

关 键 词：NEPHRIN tumor inflammation 

分 类 号：R735.35[医药卫生—肿瘤]