supported by the National Natural Science Foundation of China(82272306 and 82072270);Shandong Provincial Natural Science Foundation(ZR2024MH017);Taishan Scholars Program(tstp20221142).
In 2022,a sharp rise in global cases of mpox virus(MPXV)led the World Health Organization(WHO)to declare it a public health emergency of international concern.However,progress in developing drugs targeting MPXV has be...
the Shenzhen Science and Technology Plan(No.JCYJ20220530142009021);the National Natural Science Foundation of China(No.82060678,82060851,81760674);the Nanshan District of Shenzhen Science and Technology Project(China)(No.2019057).
IL-17 A is a promoter of colorectal cancer initiation and progression.Narciclasine is a polyhydroxy alkaloid compound isolated from Narcissus plants,which has potent anti-inflammatory and antitumor actions.The effects...
the National Natural Science Foundation of China(Grant Nos.21907044,81460559 and 82160697);Yunnan Fundamental Research Projects(Grant Nos.202101AT070155 and 202201AS070086);Basic Research Plan of Yunnan Provincial Science and Technology Department-Kunming Medical University(Grant Nos.202101AY070001-011,202201AY070001-003 and 202101AY070001-041);the Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province(Hongyu Zhou,Dandan Liu),Yunnan Academician Expert Workstation(Grant No.202305AF150054);Basic Research Project of Yunnan Provincial Department of Education(Grant No.2022J0213).
DNA topoisomerases are essential nuclear enzymes in correcting topological DNA errors and maintaining DNA integrity.Topoisomerase inhibitors are a significant class of cancer chemotherapeutics with a definite curative...