TOPOISOMERASE

作品数：45被引量：67H指数：5
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相关机构：东南大学中国科学院中山大学重庆医科大学附属第一医院更多>>
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Discovery of novel triple targeting G–quadruplex and topoisomerase 1/2 ligands from natural products evodiamine and rutaecarpine
《Chinese Chemical Letters》2023年第4期203-210,共8页Haibo Wang Xuexin Bai Yahui Huang Yueru Chen Guoqiang Dong Tianmiao Ou Shanchao Wu Defeng Xu Chunquan Sheng 
supported by the National Natural Science Foundation of China (Nos. 22077138 to S. Wu, 81725020 to C. Sheng;81872742 to G. Dong);the National Key Research and Development Program of China (No. 2020YFA0509200 to C. Sheng);Shanghai Rising-Star Program (No. 22QA1411300 to S. Wu)。
Inspired by the indolopyridoquinazoline scaffold of natural products evodiamine and rutaecarpine, novel triple G4 and Top1/2 ligands were rationally designed and synthesized. Systematic structure–activity relationshi...
关键词：Indolopyridoquinazoline G-QUADRUPLEX TOPOISOMERASE Structure-activity relationship Antitumor activity 
Narciclasine,a novel topoisomerase I inhibitor,exhibited potent anti-cancer activity against cancer cells
《Natural Products and Bioprospecting》2023年第1期482-492,共11页Meichen Wang Leilei Liang Rong Wang Shutao Jia Chang Xu Yuting Wang Min Luo Qiqi Lin Min Yang Hongyu Zhou Dandan Liu Chen Qing 
the National Natural Science Foundation of China(Grant Nos.21907044,81460559 and 82160697);Yunnan Fundamental Research Projects(Grant Nos.202101AT070155 and 202201AS070086);Basic Research Plan of Yunnan Provincial Science and Technology Department-Kunming Medical University(Grant Nos.202101AY070001-011,202201AY070001-003 and 202101AY070001-041);the Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province(Hongyu Zhou,Dandan Liu),Yunnan Academician Expert Workstation(Grant No.202305AF150054);Basic Research Project of Yunnan Provincial Department of Education(Grant No.2022J0213).
DNA topoisomerases are essential nuclear enzymes in correcting topological DNA errors and maintaining DNA integrity.Topoisomerase inhibitors are a significant class of cancer chemotherapeutics with a definite curative...
关键词：TOPOISOMERASE Narciclasine(NCS) Topo I-DNA covalent complex DNA damage Cell cycle Apoptosis 
Corrigendum:Topoisomerase Ⅱ alpha promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway
《Chinese Medical Journal》2022年第24期3024-3024,F0003,共2页
Following the original article’s publication,^([1])the authors informed us of the following errors:The Figure 5 was submitted incorrectly,while correct Figure 5 should be submitted as following.
关键词：METASTASIS FIGURE GALLBLADDER 
TopoisomeraseⅡαGene as a Marker for Prognostic Prediction of Hepatocellular Carcinoma:A Bioinformatics Analysis被引量：1
《Chinese Medical Sciences Journal》2022年第4期331-339,共9页Jin Lu Shaoguang An Junjie Ma Yue Yang Lei Zhang Peng Yu Heng Tao Yunfan Chen Haoxuan Zhang 
This work was partially supported by the Key Project of Natural Science Research of Education Department of Anhui Province(No.KJ2019A0338);Industry-University Cooperation Project of the Ministry of Education(No.202101160001).
Objective To investigate the expression of topoisomeraseⅡα(TOP2α)in hepatocellular carcinoma(HCC)and its role in predicting prognosis of HCC patients.Methods We used HCC-related datasets in UALCAN,HCCDB,and cBioPor...
关键词：topoisomeraseⅡα disease-free survival overall survival hepatocellular carcinoma bioinformatics analysis 
Target-based anticancer indole derivatives and insight into structure-activity relationship:A mechanistic review update(2018—2021)
《Acta Pharmaceutica Sinica B》2022年第7期3006-3027,共22页Ashima Dhiman Rupam Sharma Rajesh K.Singh 
the Managing Committee of Shivalik College of Pharmacy。
Cancer,which is the uncontrolled growth of cells,is the second leading cause of death after heart disease.Targeting drugs,especially to specific genes and proteins involved in growth and survival of cancer cells,is th...
关键词：INDOLE Synthesis ANTICANCER Structure-activity relationship TOPOISOMERASE Apoptosis Aromatase inhibitors Tubulin inhibitors 
New Copper (II), Palladium (II), and Platinum (II) 2-Acetylpyrazine Tert-Butylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells
《Open Journal of Medicinal Chemistry》2022年第1期1-13,共13页Edward C. Lisic Sarah N. Grossarth Sarah B. Bowman Jessica L. Hill Michael W. Beck Joseph E. Deweese Xiaohua Jiang 
The new ligand, 2-acetylpyrazine-tertbutylthiosemicarbazone (APZ-tBTSC), and its Cu(II), Pd(II) and Pt(II) complexes have been synthesized. This ligand coordinates to the metal ions in a tridentate monoanionic fashion...
关键词：TOPOISOMERASE Breast Cancer α-(N)-Heterocyclic Thiosemicarbazones 
TopoisomeraseⅡalpha promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway被引量：2
《Chinese Medical Journal》2020年第19期2321-2329,共9页Wen-Jie Lyu Yi-Jun Shu Ying-Bin Liu Ping Dong 
Background:TopoisomeraseⅡalpha(TOP2A)has been reported to play a crucial role in the tumorigenesis of various cancer types.However,the biological role of TOP2A in gallbladder cancer(GBC)remains unknown.The current st...
关键词：TopoisomeraseⅡalpha Gallbladder cancer PROLIFERATION METASTASIS Epithelial-mesenchymal transition Phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway 
Evodiamine-inspired dual inhibitors of histone deacetylase 1(HDAC1) and topoisomerase 2(TOP2) with potent antitumor activity被引量：5
《Acta Pharmaceutica Sinica B》2020年第7期1294-1308,共15页Yahui Huang Shuqiang Chen Shanchao Wu Guoqiang Dong Chunquan Sheng 
supported by National Natural Science Foundation of China(grants 81872742 to Guoqiang Dong and 81725020 to Chunquan Sheng);the National Key R&D Program of China(grant 2017YFA0506000 to Chunquan Sheng);the Innovation Program of Shanghai Municipal Education Commission(Grant 2019-01-07-00-07-E00073 to Chunquan Sheng,China)
A great challenge in multi-targetingdrug discovery is to identify drug-like lead compounds with therapeutic advantages over single target inhibitors and drug combinations.Inspired by our previous efforts in designing ...
关键词：EVODIAMINE Histone deacetylase TOPOISOMERASE Dual inhibitors Antitumor activity 
Synthesis and biological evaluation of indeno[1, 2-b]indole derivatives as dual topoisomerase Ⅰ & Ⅱ inhibitors: novel multidrug resistant reversal anticancer agents
《Journal of Chinese Pharmaceutical Sciences》2019年第11期786-801,共16页Dongbo Lu Yu Chen Shan Liu Chao Guo Xia Li Zhongjun Li Xiangbao Meng 
The National Natural Science Foundation of China(Grant No.81573272,81273370);Changjiang Scholars and Innovative Research Team in University(Grant No.IRT13028)
A single compound able to inhibit both TopoⅠandⅡmay present the advantage of improving anti-proliferative activity,with reduced toxic side effects,with respect to the combination of two inhibitors.We designed and sy...
关键词：Indeno[1 2-b]indole ANTI-CANCER TopoisomerseⅠ&Ⅱinhibitor Reverse multi-drug resistance 
Novel berberine derivatives:Design,synthesis,antimicrobial effects,and molecular docking studies被引量：7
《Chinese Journal of Natural Medicines》2018年第10期774-781,共8页YAO Ling WU Ling-Ling LI Qian HU Qin-Mei ZHANG Shu-Yuan LIU Kang JIANG Jian-Qin 
supported by the Graduate Students Scientific Research Innovation Projects of Jiangsu Province(No.CXZZ11-0804);Students Training Innovation Program of China Pharmaceutical University(201810316155)
A series of berberine derivatives were synthesized by introducing substituted benzyl groups at C-9.All these synthesized compounds（4a–4m）were screened for their in vitro antibacterial activity against four Gram-pos...
关键词：Antimicrobial drugs Berberine derivatives Molecular docking Topoisomerase Ⅱ DNA gyrase SAR 
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