G-QUADRUPLEX

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相关作者：周翔王文星谭铮叶培荣郝艳丽更多>>
相关机构：武汉大学中国科学院吉林大学中国科学院大学更多>>
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Metallo-supramolecular complexes enantioselectively target monkeypox virus RNA G-quadruplex and bolster immune responses against MPXV
《National Science Review》2025年第1期161-170,共10页Jie Yang Geng Qin Baoying Huang Hualong Song Jiewei Sun Miles Postings Peter Scott Chuanqi Zhao Chunyu Wang Wenjie Tan Jinsong Ren Xiaogang Qu 
supported by the National Key R&D Program of China(2019YFA0709202,2021YFF1200700,2022YFC2304100,2021YFA1201003);the National Natural Science Foundation of China(22437006,22237006,22122704,22107098,82241066);the Jilin Innovation Project(2023DJ02).
The Mpox virus(MPXV)has emerged as a formidable orthopoxvirus,posing an immense challenge to global public health.An understanding of the regulatory mechanisms of MPXV infection,replication and immune evasion wi l l b...
关键词：G-QUADRUPLEX ligand binding Mpox virus CHIRALITY supramolecular chemistry 
Corrigendum to: Disruption of a DNA G-quadruplex causes a gain-of-function SCL45A1 variant relevant to developmental disorders
《Acta Biochimica et Biophysica Sinica》2024年第11期1722-1722,共1页Yuxi Chen Jiang Long Sixian Wu Yazhen Wei Fei Yan Qing Li Jierui Yan Nannan Zhang Wenming Xu 
In the original version of this manuscript,an error was found in the title.Modified title is as follows.The authors apologize for this error.
关键词：function error Modified 
Simple and effective:Superlubricity behaviour of the G-quadruplex hydrogel with high selectivity for K^(+) ions based on the ocular environment
《Friction》2024年第11期2548-2562,共15页Hongdong WANG Jian WU Kunpeng WANG Yunjuan SU Xiacong ZHANG Yuhong LIU Jianhua ZHANG 
supported by the National Natural Science Foundation of China(Grant Nos.52275203 and 52105194);China Postdoctoral Science Special Funding Project(Grant No.2022T150353);the Tribology Science Fund of State Key Laboratory of Tribology in Advanced Equipment(Grant Nos.SKLTKF20A01 and SKLTKF23A04).
Hydrogels have been the subject of significant research in the field of friction due to their exceptional lubricating properties.In this study,the G-quadruplex hydrogel with high selectivity for K^(+) ions was formed ...
关键词：SUPERLUBRICITY ocular environment G-quadruplex hydrogel bio-compatibility 
G-quadruplex is involved in the regulation of BmSGF1 expression in the Silkworm, Bombyx mori
《Insect Science》2024年第5期1440-1452,共13页Yanfei Chen Jin Li Kangkang Niu Yuling Peng Qisheng Song Qili Feng 
This research was supported by the National Natural Science Foundation of China(31930102,32250710148,32000337,32100383);Shaoguan University high-level talent research start-up funding project(432/9900064607);Research Projects of Shaoguan University(SY2023KJ03).
Advanced DNA structures,such as the G-quadruplex(G4)and the i-motif,are widely but not randomly present in the genomes of many organisms.A G4 structure was identified in the promoter of the silk gland factor-1 gene(SG...
关键词：BmSGF1 G4 Bombyx mori CRISPR/Cas9 silk production 
Progress in ion detection and clinical diagnosis based on G-quadruplex combined with fluorescence properties
《Advanced Sensor and Energy Materials》2024年第3期61-70,共10页Ping Lu Gerile Aodeng Jun Ai 
supported by the National Natural Science Foundation of China(21864020,82160652);the Natural Science Foundation of Inner Mongolia(2019MS02014,2018MS02012);“Young Science and Technology Talents Program”(Leading Person)in Inner Mongolia Autonomous Region Colleges and Universities(NJYT-19-A04);Collaborative Innovation Center for Water Environmental Security of Inner Mongolia Autonomous Region,China(XTCX003);the Science and Technology Planning Project of Inner Mongolia Autonomous Region(2021GG0367).
G-quadruplex is a high-level structure composed of folded DNA or RNA rich in tandem repeats of guanine(G).In recent years,G-quadruplex is widely used in various fields due to its unique structural properties.This arti...
关键词：G-QUADRUPLEX DNA G-quadruplex RNA G-quadruplex DETECTION MEDICAL 
DNA G-Quadruplexes as Targets for Natural Product Drug Discovery
《Engineering》2024年第7期39-51,共13页Kai-Bo Wang Yingying Wang Jonathan Dickerhoff Danzhou Yang 
supported by the National Institutes of Health(R01CA177585,U01CA240346,and R01CA153821)(DY);the Purdue Center for Cancer Research(P30CA023168);the National Natural Science Foundation of China(82173707 and 82322065);the Program for Jiangsu Province Innovative Research Scholar(JSSCRC2021512);the“Double First-Class”University Project(CPUQNJC22_08).
DNA guanine(G)-quadruplexes(G4s)are unique secondary structures formed by two or more stacked Gtetrads in G-rich DNA sequences.These structures have been found to play a crucial role in highly transcribed genes,especi...
关键词：G-QUADRUPLEX Natural products ALKALOIDS CANCER PROMOTER 
Unfolding rates of 1:1 and 2:1 complex of CX-5461 and c-MYC promoter G-quadruplexes revealed by single-molecule force spectroscopy
《Biophysics Reports》2024年第3期180-189,共10页Hui Peng Yashuo Zhang Qun Luo Xinyu Wang Huijuan You 
financially supported in part by grants from the National Natural Science Foundation of China (32171225)。
CX-5461, also known as pidnarulex, is a strong G4 stabilizer and has received FDA fast-track designation for BRCA1-and BRCA2-mutated cancers. However, quantitative measurements of the unfolding rates of CX-5461-G4 com...
关键词：SINGLE-MOLECULE G-QUADRUPLEX Magnetic tweezers STOICHIOMETRY Force spectroscopy Pidnarulex 
Disruption of a DNA G-quadruplex causes a gain-of-function SCL45A1 variant relevant to developmental disorders
《Acta Biochimica et Biophysica Sinica》2024年第5期709-716,共8页Yuxi Chen Jiang Long Sixian Wu Yazhen Wei Fei Yan Qing Li Jierui Yan Nannan Zhang Wenming Xu 
supported by the grants from the Science and Technology Department of Sichuan Province(No.2021YJ0170);the Regional Innovation Cooperation Project of Sichuan Province(No.2022YFQ0100).
SLC45A1 encodes a glucose transporter protein highly expressed in the brain.Mutations in SLC45A1 may lead to neurological diseases and developmental disorders,but its exact role is poorly understood.DNA G-quadruplexes...
关键词：SLC45A1 DNA G4 transcriptional enhancement gain of function 
Colorimetric and Photothermal Dual-modal Visual Detection of Iodide Ion Based on G-Quadruplex-Hemin Cascade Signal Amplification
《Chemical Research in Chinese Universities》2024年第2期305-310,共6页CHEN Yanyue LIU Jiali LIU Jiawen HU Rong YANG Yunhui ZHANG Xiaobing 
supported by the National Natural Science Foundation of China(Nos.21864026,21605130);the Natural Science Foundation of Yunnan Province,China(Nos.2018FB016,2016FD017).
The insufficient internal resorption of iodide ions(I−)leads to thyroid disorders,such as goiter,hypothyroidism,and cretinism in adults.In this paper,a portable point-of-care testing(POCT)platform was developed for th...
关键词：Dual-modal platform G-QUADRUPLEX Iodide ion Point-of-care testing(POCT) APTASENSOR 
Evolution of Monkeypox C9L RNA G-Quadruplex Elevates the Translation of Its Only Kelch-like Protein by Accelerating G-Quadruplex Unfolding Kinetics
《CCS Chemistry》2024年第4期953-963,共11页Yicong Dai Xucong Teng Difei Hu Qiushuang Zhang Jinghong Li 
supported by the National Natural Science Foundation of China(grant nos.22034004 and 22027807);the National Key Research and Development Program of China(grant no.2021YFA1200104);the Strategic Priority Research Program of the Chinese Academy of Sciences(grant no.XDB36000000);the Vanke Special Fund for Public Health and Health Discipline Development(grant no.2022Z82WKJ003).
Genomic surveillance of monkeypox virus(MPXV)is essential to explore the reason of its unusual outbreak.Current phylogenomic analysis of the MPXV genome mainly focuses on the effect of amino acid mutations.Herein,we e...
关键词：G-QUADRUPLEX RNA secondary structure unfolding kinetics monkeypox virus genomic evolution immune evasion 
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