ALKALOIDS

作品数：340被引量：696H指数：11
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相关领域：医药卫生理学更多>>
相关作者：林文翰付宏征张霄叶文才蔡宝昌更多>>
相关机构：北京大学中国科学院南京中医药大学北京中医药大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金高等学校学科创新引智计划更多>>
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Total alkaloids from Thesium chinense inhibit lipopolysaccharide-induced respiratory inflammation by modulating Nrf2/NF-κB/NLRP3 signaling pathway
《Chinese Journal of Natural Medicines》2025年第4期421-430,共10页Guohui Li Yueqin Guan Lintao Xu Guangcheng Peng Qingtong Han Tian Wang Zhenpeng Xu Xuesen Wen Hongxiang Lou Tao Shen 
supported by the National Natural Science Foundation of China(No.82274065);Toxicology of Traditional Chinese Medicines,a High-Level Priority Subject in Chinese Medicine in National Administration of Traditional Chinese Medicine(No.ZYYZDXK-2023296);Cutting Edge Development Fund of Advanced Medical Research Institute(No.GYY2023QY01)。
Inflammation plays a pivotal role in the etiology and progression of various diseases.In traditional Chinese medicine,the whole plants of Thesium chinense Turcz.and its preparations(e.g.Bairui Granules)have been emplo...
关键词：Thesium chinense ALKALOIDS NRF2 NF-ΚB NLRP3 INFLAMMATION 
Analysis on Chemical Components of Meconopsis integrifolia(Maxim.)Franch Total Flavonoids by UPLC-Q-Exactive Orbitrap MS
《Medicinal Plant》2025年第1期1-10,共10页Yifan TIAN Yuanlin KONG Limin LI Zhengming YANG Chaoqin REN Yongcang ZHANG Yuan LIU Yanfei HUANG 
Supported by Natural Science Foundation of Sichuan Province(2023NS-FSC0610);the Special Fund of Natural Science for the Central Universities of Southwest Minzu University(ZYN2023071).
[Objectives]To analyze the chemical components of Meconopsis integrifolia(Maxim.)Franch total flavonoids(MITF).[Methods]The chemical components of MITF were identified by UPLC-Q-Exactive Orbitrap MS.The column was per...
关键词：Meconopsis integrifolia(Maxim.)Franch UPLC-Q-Exactive Orbitrap MS Total flavonoids ALKALOIDS Phenolic acids 
Analysis of Chemical Components of Cocculus laurifolius DC.Based on Liquid Chromatography-Mass Spectrometry
《Medicinal Plant》2025年第1期16-18,共3页Lintong HAN Yuzhe LI Chengxin LAN Bolin BAO Yajie WEI Haicheng WEN Wei WEI Xiaoman ZHONG 
Supported by Scientific Research Project of China Medical Association of Minorities(2022M2038-310401);Guangxi First-class Discipline Project for Traditional Chinese Medicine(GuiJiaoKeYan 202201);Scientific Research and Training Project for College Students of Guangxi University of Chinese Medicine(2023DXS14);Funding Project for High-level Innovation Team and Outstanding Scholars in Guangxi Universities(GuiJiaoRen 201407);NATCM s Project of High-level Construction of Key TCM Disciplines/Medicine for Ethnic Minorities(Zhuang Medicine)(ZYYZDXK-2023164);Guangxi Higher Education Key Laboratory for the Research of Toxic Diseases in Zhuang Medicine(GuiJiaoKeYan 202210).
[Objectives]To analyze the main chemical components in Cocculus laurifolius DC.by ultra-high performance liquid chromatography-quaternary rod/electrostatic field orbital hydrazine high resolution mass spectrometry.[Me...
关键词：Cocculus laurifolius DC. UPLC-Q-Exactive HRMS Chemical component ALKALOIDS FLAVONOIDS 
From steroidal glycoalkaloids to steroidal saponins:Biosynthesis and ecological role in the Solanum genus
《Molecular Plant》2025年第1期22-24,共3页Yan Li Jie Luo 
funded by grants from the National Natural Science Foundation of China(32100213);the Project of Sanya Yazhou Bay Science and Technology City(SCKJ-JYRC-2023-18);the Hainan Provincial Natural Science Foundation of China(222RC553,323RC423);the Hainan University Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture(XTCX2022NYC09);the Hainan University Startup Fund(RZ2100003223).
Solanaceae plants produce two major classes of valuable steroid-derived specialized metabolites:steroidal glycoalkaloids(SGAs)and steroidal saponins(STSs)(Grzech et al.,2025).SGAs are crucial in plant defense despite ...
关键词：steroidal ALKALOIDS SAPONINS 
Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids
《Science China Chemistry》2025年第1期288-296,共9页Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao 
supported by the National Natural Science Foundation of China(U1812403 to Xiao-Jiang Hao,2193304 to Yun-Dong Wu,81573323 and 31770392 to Ying-Tong Di,and 22177050 to Ming-Ming Cao);the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(2022YKZY001);the Yunnan Provincial Science and Technology Department(202003AD150012 to Xiao-Jiang Hao,202201AS070040 and 202302AA310035 to Ying-Tong Di)。
In the intricate process of natural product biosynthesis,a metabolon can enhance metabolic flux by associating sequential enzymes.A fungal metabolon,comprising of flavin-dependent monooxygenase Spe F and P450 monooxyg...
关键词：METABOLON Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids 
Protocol of clinical population pharmacokinetics/pharmacodynamics analysis of alkaloids from the leaves of Alstonia scholaris in acute bronchitis patients
《Guideline and Standard in Chinese Medicine》2024年第4期236-242,共7页Chunying He Weiyi Cao Wantong Zhang Yunli Zhao Xiaodong Luo Rui Li 
supported by the National Science of China Academy of Chinese Medical Sciences(No.zz0908022);the National Natural Science Foundation of China(81603505);the National Science and Technology major project(2017ZX09304003);the National Key Research and Development Program(2018YFC1706006).
Objective:To validate whether orally administered capsules of alkaloids from the leaves of Alstonia scholaris(CALAS)can improve the clinical indices of acute bronchitis and to investigate the alterations in the relati...
关键词：acute tracheobronchitis dengtaiye capsules PHARMACOKINETICS/PHARMACODYNAMICS population 
A General Protocol toward Oxindoles Bearing C_(3)-Allylic Quaternary Stereocenter via Domino Reaction:A Concise Synthesis of Heterocycle-Fused Indoline Alkaloids
《Chinese Journal of Chemistry》2024年第20期2459-2465,共7页Hanxiao Yang Ruoqian Fan Daheng Wen Mengmeng Fan Weiwei Fang 
National Natural Science Foundation of China(No.22101133);Natural Science Foundation of Jiangsu Province(No.BK20200768)and Nanjing Forestry University are greatly acknowledged.
An efficiently catalytic method toward the synthesis of indolin-2-ones featuring an allylic derived C_(3)-quaternary stereocenter via an intramolecular Heck cyclization/Suzuki coupling of N-substituted-N-(2-bromopheny...
关键词：C3-Allylic quaternary stereocenter 3 3'-Disubstituted oxindoles Domino reaction Indoline alkaloids Molecular diversity Nitrogen heterocycles Organohalides Palladacyclic N-heterocyclic carbene 
Discovery and Asymmetric Total Synthesis of Phlegmine A as a Selective Inhibitor of ASIC1a
《CCS Chemistry》2024年第10期2529-2536,共8页Zai-Feng Yuan Fei Liu Yu-Fei Ou Wen-Yan Li Li-Yan Peng Xiao-Nian Li Qin-Shi Zhao 
the National Natural Science Foundation of China(NSFC;grant no.21837003);the Joint Foundation of NSFC-Yunnan Province(grant no.U1502223);the Yunnan Revitalization Talent Support Program“Young Talent”Project,NSFC(grant no.81903521);the Natural Science Foundation of Yunnan Province,China(grant no.202001AT070067).
Phlegmine A(1),a novel type of Lycopodium alkaloid with a unique skeleton,was isolated from the rare and endangered herbal medicinal plant,Phlegmariurus phlegmaria.Spectroscopic methods and X-ray diffraction analysis ...
关键词：Lycopodium alkaloids phlegmine A total synthesis ASIC1a inhibitor ANALGESIC 
Pharmacokinetics of Gelsemium elegans in female rats
《Pharmacology Discovery》2024年第3期17-21,共5页Xiao-Tong Zhang Jun-Jie Cao Meng-Ting Zuo Zhao-Ying Liu 
supported by the National Natural Science Foundation of China(No.31972737).
Background:Gelsemium elegans Benth(G.elegans)is a poisonous perennial evergreen vine plant that has been applied in livestock production and veterinary clinical practice.Early studies found that the toxicity of G.eleg...
关键词：Gelsemium elegans ALKALOIDS PHARMACOKINETICS female rats 
Study of the Effectiveness of Papaver Sp. Alkaloids as Future Therapeutic Alternatives against Enterococcus Sp. Causing Hospital-Acquired Septicemic Infections
《Journal of Biosciences and Medicines》2024年第8期107-127,共21页Lama Mohammed Ayoub Shbibe Georgette Antranik Babojian 
Background and Objective: In recent years, control of Enterococcus sp. It has been proven in the local medical environment to be a cause of acquired septicemia in various age groups, and medical instruments are consid...
关键词：CATHETERS Skin Ulcers Acquired Infection Multi-Resistant Enterococcus Sp. Papaver Sp. Alkaloids Minimum Inhibitory and Lethal Concentration 
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