From steroidal glycoalkaloids to steroidal saponins:Biosynthesis and ecological role in the Solanum genus  

作　　者：Yan Li Jie Luo 

机构地区：[1]School of Breeding and Multiplication(Sanya Institute of Breeding and Multiplication),Hainan University,Sanya 572025,China [2]Yazhouwan National Laboratory,Sanya 572025,China

出　　处：《Molecular Plant》2025年第1期22-24,共3页分子植物(英文版)

基　　金：funded by grants from the National Natural Science Foundation of China(32100213);the Project of Sanya Yazhou Bay Science and Technology City(SCKJ-JYRC-2023-18);the Hainan Provincial Natural Science Foundation of China(222RC553,323RC423);the Hainan University Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture(XTCX2022NYC09);the Hainan University Startup Fund(RZ2100003223).

摘　　要：Solanaceae plants produce two major classes of valuable steroid-derived specialized metabolites:steroidal glycoalkaloids(SGAs)and steroidal saponins(STSs)(Grzech et al.,2025).SGAs are crucial in plant defense despite their anti-nutritional effects on humans.They also exhibit diverse biological activities,including anti-cancer,anti-microbial,anti-inflammatory,anti-viral,and anti-pyretic activities(Lucier et al.,2024).Similarly,STSs have garnered significant interest from the pharmaceutical,cosmetic,and food industries for many years due to their detergent-like properties(Grzech et al.,2025).However,the ecological roles of STSs are still unknown,and efforts to reconstitute the biosynthesis of SGAs and STSs in heterologous hosts have not been successful.A recent work,published in Science by Sarah E.O’Connor and Prashant D.Sonawane’s team,unveils a cellulose synthase-like protein(GLYCOALKALOID METABOLISM15[GAME15])that is required for the biosynthesis of both SGAs and STSs and provides the first definitive evidence for STSs’role in plant defense(Boccia et al.,2024).This discovery elucidates the entire biosynthetic pathway of SGAs and STSs,opening up new opportunities for their metabolic engineering.

关 键 词：steroidal ALKALOIDS SAPONINS 

分 类 号：O62[理学—有机化学]