supported by the National Science of China Academy of Chinese Medical Sciences(No.zz0908022);the National Natural Science Foundation of China(81603505);the National Science and Technology major project(2017ZX09304003);the National Key Research and Development Program(2018YFC1706006).
Objective:To validate whether orally administered capsules of alkaloids from the leaves of Alstonia scholaris(CALAS)can improve the clinical indices of acute bronchitis and to investigate the alterations in the relati...
Effective treatment of sepsis not only demands prompt administration of appropriate antimicrobials but also requires precise dosing to enhance the likelihood of patient survival. Adequate dosing refers to the administ...
supported by the CAMS Innovation Fund for Medical Sciences(CIFMS,No.2021-I2M-1-027);National Natural Science Foundation of China(Nos.T2192972,81402997);Key Project of Beijing Natural Science Foundation(No.7181007);National High-tech Research and Development Plan(863 Plan,No.2014AA020803);Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study(No.Z141102004414062)。
A nine cyclic peptide(TCP-1)showed excellent specificity for colon cancer.TCP-1 binds with human tumor tissues at early stages and mice tumor with diameters of 1-4 mm,suggesting that TCP-1 may be used for early diagno...
BACKGROUND Itraconazole is a broad-spectrum triazole antifungal inhibiting fungal growth by inhibiting ergosterol synthesis and exhibits a nonlinear pharmacokinetic profile.Erratic absorption pattern with wide fluctua...
Invasive candidiasis was the most common nosocomial fungal infection with high morbidity and mortality, which is mainly occurring in immunodeficiency and critical patients. Echinocandins were recommended as first-line...
Aim: Antofloxacin hydrochloride is a new fluoroquinolone antibiotic with broad-spectrum in vitro activity. Using the neutropenic murine thigh infection model, we defined the pharmacodynamic profile and property of an...