PHARMACOKINETICS/PHARMACODYNAMICS

作品数:6被引量:2H指数:1
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Protocol of clinical population pharmacokinetics/pharmacodynamics analysis of alkaloids from the leaves of Alstonia scholaris in acute bronchitis patients
《Guideline and Standard in Chinese Medicine》2024年第4期236-242,共7页Chunying He Weiyi Cao Wantong Zhang Yunli Zhao Xiaodong Luo Rui Li 
supported by the National Science of China Academy of Chinese Medical Sciences(No.zz0908022);the National Natural Science Foundation of China(81603505);the National Science and Technology major project(2017ZX09304003);the National Key Research and Development Program(2018YFC1706006).
Objective:To validate whether orally administered capsules of alkaloids from the leaves of Alstonia scholaris(CALAS)can improve the clinical indices of acute bronchitis and to investigate the alterations in the relati...
关键词:acute tracheobronchitis dengtaiye capsules PHARMACOKINETICS/PHARMACODYNAMICS population 
Understanding antimicrobial pharmacokinetics in critically ill patients to optimize antimicrobial therapy:A narrative review
《Journal of Intensive Medicine》2024年第3期287-298,共12页Claire Roger 
Effective treatment of sepsis not only demands prompt administration of appropriate antimicrobials but also requires precise dosing to enhance the likelihood of patient survival. Adequate dosing refers to the administ...
关键词:PHARMACOKINETICS/PHARMACODYNAMICS ICU ANTIBIOTICS Dose optimization TDM 
TCP-1,a novel peptide to diagnose early colon cancer
《Chinese Chemical Letters》2024年第3期226-233,共8页Hang Yu Baoying Wen Min Huang Ru Feng Libin Pan Manyi Xu Hao Lin Lin Cong Sen Zhang Yan Li Chi-Hin Cho Chongjing Zhang Xiaoguang Chen Yan Wang 
supported by the CAMS Innovation Fund for Medical Sciences(CIFMS,No.2021-I2M-1-027);National Natural Science Foundation of China(Nos.T2192972,81402997);Key Project of Beijing Natural Science Foundation(No.7181007);National High-tech Research and Development Plan(863 Plan,No.2014AA020803);Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study(No.Z141102004414062)。
A nine cyclic peptide(TCP-1)showed excellent specificity for colon cancer.TCP-1 binds with human tumor tissues at early stages and mice tumor with diameters of 1-4 mm,suggesting that TCP-1 may be used for early diagno...
关键词:Colon cancer TCP-1 PEPTIDE Cytokeratin 5 Pharmacokinetics/pharmacodynamics(PK/PD) 
Pharmacokinetics/Pharmacodynamics study of Fixtral SB as compared to supra bioavailable itraconazole and conventional itraconazole
《World Journal of Pharmacology》2023年第1期1-11,共11页Syed Mujtaba Hussain Naqvi Monil Yogesh Neena Gala Snehal Muchhala Anand Arumugam Dhananjay Panigrahi Dipak Patil Rahul Rathod Amey Mane 
BACKGROUND Itraconazole is a broad-spectrum triazole antifungal inhibiting fungal growth by inhibiting ergosterol synthesis and exhibits a nonlinear pharmacokinetic profile.Erratic absorption pattern with wide fluctua...
关键词:Supra-Bioavailable itraconazole Conventional itraconazole Oral bioavailability PHARMACODYNAMICS EFFICACY Adverse events 
Optimization of Dosage Regimen of Rezafungin against <i>Candida spp. </i>Based on Pharmacokinetic/Pharmacodynamic Analysis
《Pharmacology & Pharmacy》2020年第6期79-84,共6页Jiuli Hu Junhui Hu 
Invasive candidiasis was the most common nosocomial fungal infection with high morbidity and mortality, which is mainly occurring in immunodeficiency and critical patients. Echinocandins were recommended as first-line...
关键词:Invasive Candidiasis Rezafungin PHARMACOKINETICS/PHARMACODYNAMICS Monte Carlo Simulation 
Pharmacokinetics/pharmacodynamics of antofloxacin hydrochloride in a neutropenic murine thigh model of Staphylococcus aureus infection被引量:2
《Acta Pharmacologica Sinica》2008年第10期1253-1260,共8页Xiu-mei XIAO Yong-hong XIAO 
Aim: Antofloxacin hydrochloride is a new fluoroquinolone antibiotic with broad-spectrum in vitro activity. Using the neutropenic murine thigh infection model, we defined the pharmacodynamic profile and property of an...
关键词:antofloxacin hydrochloride PK/PD murine thigh infection model Staphylococcus aureus AUC24h/MIC 
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