Optimization of Dosage Regimen of Rezafungin against <i>Candida spp. </i>Based on Pharmacokinetic/Pharmacodynamic Analysis  

作　　者：Jiuli Hu Junhui Hu Jiuli Hu;Junhui Hu(Department of Clinic Pharmacy, Affiliated of Chengde Medical College, Chengde, China;Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde, China)

机构地区：[1]Department of Clinic Pharmacy, Affiliated of Chengde Medical College, Chengde, China [2]Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde, China

出　　处：《Pharmacology & Pharmacy》2020年第6期79-84,共6页药理与制药（英文）

摘　　要：Invasive candidiasis was the most common nosocomial fungal infection with high morbidity and mortality, which is mainly occurring in immunodeficiency and critical patients. Echinocandins were recommended as first-line drugs for the treatment and prevention of invasive candidiasis. In our study, we aimed to optimize the dosage of Rezafungin against <i><i><span style="font-family:Verdana;">Candida</span></i><span> <i><span style="font-family:Verdana;">spp.</span></i><span style="font-family:Verdana;"> </span></span></i><span style="font-family:Verdana;"> based on pharmacokinetic/pharmacodynamics (PK/PD) analysis. We collected the published data about pharmacokinetic parameters of rezafungin and the MIC distribution of <i></i></span><i><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> <i>spp</i></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">.</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> </span></span></span></i> on <span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">rezafungin</span><i><span style="font-family:Verdana;">.</span></i><span style="font-family:Verdana;"> Monte Carlo simulation was used to calculate probability of target attainment and a cumulative fraction of response to assess the best dosing regimen. The optimal dosage regimen for <i></i></span><i><i><span style="font-family:Verdana;">C.</span></i><span style="font-family:Verdana;"> <i>albicans</i></span> <span style="font-family:Verdana;"></span></i></span><span style="font-family:Verdana;">and <i></i></span><i><i><span style="font-family:Verdana;">C.</span></i><span> <i><span style="font-family:Verdana;">glabrata </span></i><span style="font-family:Verdana;"></span></span></i></span></span><span style="font-family:Verdana;">was 50 mg IV, and the optimal dosage regimen for <i></i></span><i><i><span style="font-family:Verdana;">C.</Invasive candidiasis was the most common nosocomial fungal infection with high morbidity and mortality, which is mainly occurring in immunodeficiency and critical patients. Echinocandins were recommended as first-line drugs for the treatment and prevention of invasive candidiasis. In our study, we aimed to optimize the dosage of Rezafungin against <i><i><span style="font-family:Verdana;">Candida</span></i><span> <i><span style="font-family:Verdana;">spp.</span></i><span style="font-family:Verdana;"> </span></span></i><span style="font-family:Verdana;"> based on pharmacokinetic/pharmacodynamics (PK/PD) analysis. We collected the published data about pharmacokinetic parameters of rezafungin and the MIC distribution of <i></i></span><i><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> <i>spp</i></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">.</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> </span></span></span></i> on <span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">rezafungin</span><i><span style="font-family:Verdana;">.</span></i><span style="font-family:Verdana;"> Monte Carlo simulation was used to calculate probability of target attainment and a cumulative fraction of response to assess the best dosing regimen. The optimal dosage regimen for <i></i></span><i><i><span style="font-family:Verdana;">C.</span></i><span style="font-family:Verdana;"> <i>albicans</i></span> <span style="font-family:Verdana;"></span></i></span><span style="font-family:Verdana;">and <i></i></span><i><i><span style="font-family:Verdana;">C.</span></i><span> <i><span style="font-family:Verdana;">glabrata </span></i><span style="font-family:Verdana;"></span></span></i></span></span><span style="font-family:Verdana;">was 50 mg IV, and the optimal dosage regimen for <i></i></span><i><i><span style="font-family:Verdana;">C.</

关 键 词：Invasive Candidiasis Rezafungin PHARMACOKINETICS/PHARMACODYNAMICS Monte Carlo Simulation 

分 类 号：O17[理学—数学]