PEPTIDE

作品数：1070被引量：2052H指数：15
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相关机构：北京大学福建医科大学复旦大学军事医学科学院更多>>
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Peptide bridging for cofactor channeling in fusion enzyme lowers cofactor input by two orders of magnitude
《Chinese Journal of Catalysis》2025年第4期390-403,共14页Zehui Guo Yan Sun 
国家重点研发计划(2018YFA0900702).
Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor ...
关键词：Peptide bridge Fusion enzyme NADP(H)-dependent oxidoreductases Cofactor channeling Cofactor regeneration 
Biphenyl-dihydrothiazole-cyclized peptide libraries for peptide ligand and drug discovery
《Science China Chemistry》2025年第4期1434-1444,共11页Junjie Liu Xiangnan Sun Jie Zhuang Ziyan Liu Chaoying Xu Dalei Wu Chuanliu Wu 
the financial support from the National Natural Science Foundation of China(22174119 and 21974115);the Fundamental Research Funds for the Central Universities(20720210001 and 20720220005);the Program for Changjiang Scholars and Innovative Research Team in University(IRT_17R66);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(21521004)to C.Wu;the University Innovation Group Program of Jinan(202228080);the Shandong Provincial Natural Science Foundation(ZR2021JQ30);the Taishan Scholar Program of Shandong Province(tsqn201909004)to D.Wu.
Utilizing diverse organic crosslinkers for cyclization has proven to be an effective approach to creating peptide libraries;enabling the rapid discovery of functional peptides.Existing crosslinkers usually provide a t...
关键词：PEPTIDE phage display protein interaction cyclic peptide fluorescence 
Silkworm pupa peptide ameliorates dextran sulfate sodium-induced colitis by enhancing gut barriers and modifying gut flora
《Food Science and Human Wellness》2025年第2期758-768,共11页Yaxi Zhou Diandian Wang Hao Duan Shiqi Zhou Jinhong Guo Yu Guo Jian Zhao Wenjie Yan 
supported by the National Key Research and Development Program of China(2023YFF1103802)。
The anti-inflammatory properties of silkworm pupa peptide(SPP)have been recognized for their potential benefits in colitis treatment.However,the underlying mechanism of SPP in colitis animal models remains unclear.The...
关键词：Silkworm pupa peptide Ulcerative colitis Intestinal barrier Gut flora Short-chain fatty acids 
Systemically intravenous siRNA delivery into brain with a targeting and efficient polypeptide carrier and its evaluation on anti-glioma efficacy
《Chinese Chemical Letters》2025年第3期396-401,共6页Liqing Chen Zheming Zhang Yanhong Liu Chenfei Liu Congcong Xiao Liming Gong Mingji Jin Zhonggao Gao Wei Huang 
supported by CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-026,China).
Gliomas are the most common intracranial tumors with poor survival and high mortality.Furthermore,the clinical efficacy of current drugs is still not ideal;despite the development of several therapeutic drugs over the...
关键词：15-Amino-acid peptide GLIOMA Brain targeting Gene silencing Transvascular delivery 
Correction to:Scorpion Venom Heat‑Resistant Peptide is Neuroprotective Against Cerebral Ischemia‑Reperfusion Injury in Association with the NMDA‑MAPK Pathway
《Neuroscience Bulletin》2025年第3期549-550,共2页
In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis
《Science Bulletin》2025年第3期407-418,共12页Da-Yong Hou Ni-Yuan Zhang Peng Zhang Xiang-Peng Li Jiong-Cheng Wu Mei-Yu Lv Zhi-Jia Wang Xing-Jie Hu Jian-Xiao Liang Hong-Lei Wang Yue-Ze Wang Hui-Hui You Hong-Wei An Hao Wang Wanhai Xu 
supported by the National Key R&D Program of China(2022YFA1205701 and 2020YFA0210800);the National Natural Science Foundation of China(52322308,51725302,52273126,11621505,and 82302266);Beijing Nova Program(20230484237);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB36000000);the Key Research and Development Program of Heilongjiang Province(2022zX06004);Hong Kong scholar project(Xj2024052);Harbin Medical University Cancer Hospital Haiyan Foundation(JYQ2024-03 and JZD2024-17);the Nn10 program of Harbin Medical University Cancer Hospital(Nn102024-01);the Climing program of Harbin Medical University Cancer Hospital(PDYS2024-03);China Postdoctoral Science Foundation(2024MD753933);Heilongjiang Postdoctoral Fund(LBH-Z23221).
Tumor metastasis accounts for over 90%of tumor-related deaths,prompting the development of fluorescently labeled tumor-specific molecular imaging agents for differentiating tumors from normal tissues.However,early det...
关键词：Self-assembly PEPTIDE NANOMATERIAL Fluorescence imaging Bladder cancer 
Novel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury
《Journal of Biomedical Research》2025年第1期61-75,共15页Xuejun Xu Kaineng Sun Hao Chang Chunxiang Shen Xiangdong Li Yangyue Ni Yuxiao Zhu Huiquan Wang Ruiyan Xiong Jon Rob Padde Zhipeng Xu Lin Chen Lu Chen Min Hou Liyong Pu Minjun Ji 
supported by the National Natural Science Foundation of China(Grant No.81971965)。
Ischemia-reperfusion injury(IRI)remains an unavoidable challenge in liver surgery,with macrophages playing a critical role in its pathogenesis.However,the mechanisms by which macrophages regulate the pathogenesis of I...
关键词：schistosome-derived peptide liver ischemia-reperfusion injury MACROPHAGE toll-like receptor-4 
Fusion of Dual-targeting Peptides with MAP30 Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells
《中国生物化学与分子生物学报》2025年第2期260-272,共13页YANG Yi-Xuan WANG Xin-Yi CHEN Wei-Wei GAN Li SUN Yu LIN Tong ZHAO Wei-Chun ZHU Zhen-Hong 
浙江省大学生科技创新活动计划(No.2024R410A050);浙江中医药大学科研基金(No.2024GJYY15)资助。
Momordica antiviral protein 30 kD(MAP30)is a type I ribosome-inactivating protein(RIP)with antibacterial,anti-HIV and antitumor activities but lacks the ability to target tumor cells.To increase its tumor-targeting ab...
关键词：arginine-glycine-aspartic peptide(RGD) epidermal growth factor receptor interference peptide(EGFRi) momordica antiviral protein(MAP30) MDA-MB-231 cell tumor targeting APOPTOSIS 
Enhanced radiotheranostic targeting of integrinα5β1 with PEGylation-enabled peptide multidisplay platform(PEGibody):A strategy for prolonged tumor retention with fast blood clearance
《Acta Pharmaceutica Sinica B》2025年第2期692-706,共15页Siqi Zhang Xiaohui Ma Jiang Wu Jieting Shen Yuntao Shi Xingkai Wang Lin Xie Xiaona Sun Yuxuan Wu Hao Tian Xin Gao Xueyao Chen Hongyi Huang Lu Chen Xuekai Song Qichen Hu Hailong Zhang Feng Wang Zhao-Hui Jin Ming-Rong Zhang Rui Wang Kuan Hu 
supported by the National Natural Science Foundation of China(No.82372002);the Nonprofit Central Research Institute Fund of the Chinese Academy of Medical Sciences(No.2022-RC350-04,China);the CAMS Innovation Fund for Medical Sciences(Nos.2021-I2M-1-026(2023),2022-I2M-2-002-2,and 2021-I2M-3-001(2023),China);the National Key Research and Development Program of China(No.2022YFE0111700);the Beijing Nova Program to Kuan Hu(No.0104002,China);supported by the Beijing Natural Science Foundation(No.L234044,China);the Fundamental Research Funds for the Central Universities(Nos.3332023044 and 3332023151,China);the CIRP Open Fund of Radiation Protection Laboratories(No.ZHYLYB2021005,China);the China National Nuclear Corporation Young Talent Program.
Peptide-based radiopharmaceuticals targeting integrinα5β1 show promise for precise tumor diagnosis and treatment.However,current peptide-based radioligands that targetα5β1 demonstrate inadequate in vivo performanc...
关键词：Integrinα5β1 PEPTIDE PET imaging Targeted radionuclide therapy PEGYLATION TUMOR Multidisplay PEGibody 
The First Non-Chordates QRFP-Like Peptide Receptor Gene in the Cephalopod Sepiella japonica:Identification,Characterization and Possible Role in Food Intake
《Journal of Ocean University of China》2025年第1期195-208,共14页LI Shuang HAO Qing QIU Jiayin ZHOU Xu CHI Changfeng ZHENG Libing 
supported by the National Natural Science Foundation of China(No.31872547);the Natural Science Foundation of Zhejiang Province,China(No.LTGN24C190015);the Excellent Postdoctoral Program of Jiangsu Province(No.314865)。
The novel identified receptor,GPR103,now renamed QRFPR(also referred to as SP9155 or AQ27),is the endogenous receptor for the neuropeptide QRFP(also referred to as 26RFa).The distribution pattern,structure,and biologi...
关键词：NEUROPEPTIDE 26RFa/QRFP QRFP-like peptide receptor CUTTLEFISH Sepiella japonica 
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