Silkworm pupa peptide ameliorates dextran sulfate sodium-induced colitis by enhancing gut barriers and modifying gut flora  

作　　者：Yaxi Zhou Diandian Wang Hao Duan Shiqi Zhou Jinhong Guo Yu Guo Jian Zhao Wenjie Yan 

机构地区：[1]Beijing Key Laboratory of Bioactive Substances and Functional Food,College of Biochemical Engineering,Beijing Union University,Beijing 100023,China

出　　处：《Food Science and Human Wellness》2025年第2期758-768,共11页食品科学与人类健康(英文)

基　　金：supported by the National Key Research and Development Program of China(2023YFF1103802)。

摘　　要：The anti-inflammatory properties of silkworm pupa peptide(SPP)have been recognized for their potential benefits in colitis treatment.However,the underlying mechanism of SPP in colitis animal models remains unclear.The objective of our work was to investigate the improving effect and the mechanism of action of SPP on a mouse model of dextran sulfate sodium(DSS)-induced colitis.The findings suggested that SPP effectively eased ulcerative colitis(UC)symptoms in mice by decreasing disease activity index,ameliorating histopathological injury,and decreasing serum and colonic markers of inflammation.In addition,our research findings demonstrated that SPP restored intestinal barrier function by increasing the production of tight junction proteins such as zonula occludens-1(ZO-1),claudin-1,claudin-3,occludin,and adherens junction protein E-cadherin1.Further,SPP supplementation enhanced the concentration of short-chain fatty acids and positively altered the makeup of the gut bacteria in the mice's gut.These findings underscore SPP's ability to slow the progression of colitis and point to its possible use as a functional component in dietary supplements for the prevention of early-stage colitis.

关 键 词：Silkworm pupa peptide Ulcerative colitis Intestinal barrier Gut flora Short-chain fatty acids 

分 类 号：R57[医药卫生—消化系统]