PEGYLATION

作品数：45被引量：206H指数：5
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相关作者：王永祥蒋志龙王薇禹立霞张学农更多>>
相关机构：上海交通大学军事医学科学院中国药科大学中国科学院更多>>
相关期刊：《Journal of Wuhan University of Technology(Materials Science)》《Science China(Life Sciences)》《Regenerative Biomaterials》《Acta Pharmacologica Sinica》更多>>
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Enhanced radiotheranostic targeting of integrinα5β1 with PEGylation-enabled peptide multidisplay platform(PEGibody):A strategy for prolonged tumor retention with fast blood clearance
《Acta Pharmaceutica Sinica B》2025年第2期692-706,共15页Siqi Zhang Xiaohui Ma Jiang Wu Jieting Shen Yuntao Shi Xingkai Wang Lin Xie Xiaona Sun Yuxuan Wu Hao Tian Xin Gao Xueyao Chen Hongyi Huang Lu Chen Xuekai Song Qichen Hu Hailong Zhang Feng Wang Zhao-Hui Jin Ming-Rong Zhang Rui Wang Kuan Hu 
supported by the National Natural Science Foundation of China(No.82372002);the Nonprofit Central Research Institute Fund of the Chinese Academy of Medical Sciences(No.2022-RC350-04,China);the CAMS Innovation Fund for Medical Sciences(Nos.2021-I2M-1-026(2023),2022-I2M-2-002-2,and 2021-I2M-3-001(2023),China);the National Key Research and Development Program of China(No.2022YFE0111700);the Beijing Nova Program to Kuan Hu(No.0104002,China);supported by the Beijing Natural Science Foundation(No.L234044,China);the Fundamental Research Funds for the Central Universities(Nos.3332023044 and 3332023151,China);the CIRP Open Fund of Radiation Protection Laboratories(No.ZHYLYB2021005,China);the China National Nuclear Corporation Young Talent Program.
Peptide-based radiopharmaceuticals targeting integrinα5β1 show promise for precise tumor diagnosis and treatment.However,current peptide-based radioligands that targetα5β1 demonstrate inadequate in vivo performanc...
关键词：Integrinα5β1 PEPTIDE PET imaging Targeted radionuclide therapy PEGYLATION TUMOR Multidisplay PEGibody 
PEGylated bacteria restore intestinal mucosal barrier
《Acta Pharmaceutica Sinica B》2024年第9期4186-4188,共3页Menghang Zu Xue Xia Bo Xiao 
the National Natural Science Foundation of China(82072060).
The mucosal barrier of the gastrointestinal tract(GIT)is crucial for the overall health of the body.Its disruption permits the infiltration of intestinal microorganisms into the underlying mucosa,resulting in infectio...
关键词：PEGYLATION Probiotic Mucus penetration Colonic mucosal barrier COLITIS Diabetes 
Di-PEGylated insulin:A long-acting insulin conjugate with superior safety in reducing hypoglycemic events
《Acta Pharmaceutica Sinica B》2024年第6期2761-2772,共12页Zhipeng Zeng Runcheng Tan Shi Chen Haolin Chen Zhijia Liu Lixin Liu Mingqiang Li Yongming Chen 
supported by the National Natural Science Foundation of China(No.51820105004,China);the Key Areas Research and Development Program of Guangzhou(No.202007020006,China).
Although the discovery of insulin 100 years ago revolutionized the treatment of diabetes,its therapeutic potential is compromised by its short half-life and narrow therapeutic index.Current long-acting insulin analogs...
关键词：Diabetes INSULIN Therapeutic index HYPOGLYCEMIA PEGYLATION Receptor-mediated clearance HALF-LIFE Diabetic nephropathy 
Supramolecular approaches for insulin stabilization without prolonged duration of action
《Acta Pharmaceutica Sinica B》2023年第5期2281-2290,共10页Rolande Meudom Yanxian Zhang Michael A.VandenBerg Lei Zou Yi Wolf Zhang Matthew J.Webber Danny Hung-Chieh Chou 
NIDDK(DK120430,DK121336,USA)to Danny Hung-Chieh Chou;JDRF(5-CDA-2020-947-A-N,USA)to Matthew J.Webber。
Aggregation represents a significant challenge for the long-term formulation stability of insulin therapeutics.The supramolecular PEGylation of insulin with conjugates of cucurbit[7]uril and polyethylene glycol(CB[7]-...
关键词：Diabetes mellitus Insulin aggregation Supramolecular PEGylation Selective N-Terminal modification N-terminal acid-modified insulin Subcutaneous depot HYPOGLYCEMIA Subcutaneous administration 
Long-acting growth hormone in 2022
《Pediatric Investigation》2023年第1期36-42,共7页Margaret Steiner Jacklyn Frank Paul Saenger 
After the isolation of pituitary growth hormone(GH)in 1957,this form of GH,always in limited supply,was the only drug available for the treatment of GH deficiency.In 1985,recombinant GH became available,and the modali...
关键词：Long-acting growth hormone Pegylation of growth hormone Prodrug of growth hormone Albumin binding of growth hormone Growth hormone fusion proteins 
Liposome based drug delivery as a potential treatment option for Alzheimer’s disease被引量：6
《Neural Regeneration Research》2022年第6期1190-1198,共9页Carely Hernandez Surabhi Shukla 
Alzheimer’s disease is a neurodegenerative condition leading to atrophy of the brain and robbing nearly 5.8 million individuals in the United States age 65 and older of their cognitive functions.Alzheimer’s disease ...
关键词：Alzheimer’s disease BETA-AMYLOID blood-brain barrier brain delivery drug delivery systems encapsulated drugs liposomes nanoparticles neurodegenerative diseases PEGYLATION targeted delivery tau 
Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer被引量：1
《Journal of Pharmaceutical Analysis》2022年第2期232-242,共11页Yang-Yang Wang Liang Li Xiu-Jun Liu Qing-Fang Miao Yi Li Meng-Ran Zhang Yong-Su Zhen 
supported by grants from CAMS Innovation Fund for Medical Sciences(Grant No.:2021-I2M-1-026);Scientific Research Project of Tianjin Education Commission(Grant No.:2020KJ140);Tianjin Health Research Project(Grant No.:KJ20017)。
Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmo...
关键词：Pancreatic cancer Folate receptor Multi-functional Macropinocytosis-enhanced BIOCONJUGATE K-RAS PEGYLATION 
Impact of the amount of PEG on prodrug nanoassemblies for efficient cancer therapy被引量：5
《Asian Journal of Pharmaceutical Sciences》2022年第2期241-252,共12页Yaqiao Li Lingxiao Li Qianhui Jin Tian Liu Jin Sun Yongjun Wang Zhijun Yang Zhonggui He Bingjun Sun 
financially supported by National Natural Science Foundation of China (no. 81872816);Doctoral Scientific Research Staring Foundation of Liaoning Province (no. 2021BS-130);General Program of Department of Education of Liaoning Province (no. LJKZ0953)
PEGylation has been widely used to improve the pharmacokinetic properties of prodrug self-assembled nanoparticles(prodrug-SANPs).However,the impacts of the amount of PEG on the self-assemble stability,cellular uptake,...
关键词：PEGYLATION PRODRUG Self-assembly nanoparticles DOCETAXEL Oxidation responsive 
Accurate construction of cell membrane biomimetic graphene nanodecoys via purposeful surface engineering to improve screening efficiency of active components of traditional Chinese medicine被引量：3
《Acta Pharmaceutica Sinica B》2022年第1期394-405,共12页Qi Hu Lanlan Jia Xiaolin Zhang Aihong Zhu Sicen Wang Xiaoyu Xie 
National Natural Science Foundation of China(Nos.82073807 and 81973277);the WorldClass Universities(Disciplines)and the Characteristic Development Guidance Funds for the Central Universities(No.PY3A012,China)for financial support。
Biomimetic nanoengineering presents great potential in biomedical research by integrating cell membrane(CM) with functional nanoparticles. However, preparation of CM biomimetic nanomaterials for custom applications th...
关键词：Cell membrane Biomimetic nanoengineering Purposeful surface engineering Graphene oxide Dispersity Active components screening Traditional Chinese medicine PEGYLATION 
Poly(L-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization
《Bioactive Materials》2021年第9期2688-2697,共10页Zhongyu Jiang Xiangru Feng Haoyang Zou Weiguo Xu Xiuli Zhuang 
The study was financially supported by the National Natural Science Foundation of China(Grant Nos.52073280,51973216,and 51673187).
PEGylation has been widely applied to prolong the circulation times of nanomedicines via the steric shielding effect,which consequently improves the intratumoral accumulation.However,cell uptake of PEGylated nanoformu...
关键词：Poly(L-glutamic acid) Detachable PEGylation Prolonged circulation time Enhanced cell uptake Platinum chemotherapy 
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