PEGylated bacteria restore intestinal mucosal barrier  

作　　者：Menghang Zu Xue Xia Bo Xiao 

机构地区：[1]State Key Laboratory of Resource Insects,College of Sericulture,Textile,and Biomass Sciences,Southwest University,Chongqing 400715,China [2]Department of Pharmacy,Personalized Drug Therapy Key Laboratory of Sichuan Province,Sichuan Provincial People’s Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第9期4186-4188,共3页药学学报（英文版）

基　　金：the National Natural Science Foundation of China(82072060).

摘　　要：The mucosal barrier of the gastrointestinal tract(GIT)is crucial for the overall health of the body.Its disruption permits the infiltration of intestinal microorganisms into the underlying mucosa,resulting in infections and inflammatory conditions,such as inflammatory bowel disease(IBD),metabolic disorders,and autoimmune diseases^(1,2).Therefore,strategies to protect the mucosal barrier from exogenous stimuli or to facilitate its recovery have become increasingly important.Currently,immunomodulators,corticosteroids,and biological agents have been widely employed to treat IBD by alleviating inflammation and enhancing mucosal healing.Unfortunately,they can also produce serious systemic toxicity^(3,4);therefore,there is an urgent need for exploiting innovative strategies to fortify the intestinal mucosal barrier against the invasion of exogenous damaging factors.

关 键 词：PEGYLATION Probiotic Mucus penetration Colonic mucosal barrier COLITIS Diabetes 

分 类 号：R574[医药卫生—消化系统]