云南高校图书馆联盟文献共享服务平台- BETA-AMYLOID

BETA-AMYLOID: 作品数：54被引量：208H指数：8; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：肖保国张鑫辰尉杰忠霍明章丰玲更多>>; 相关机构：中山大学清华大学复旦大学山西中医学院更多>>; 相关期刊：《中国生物学文摘》《Acta Pharmacologica Sinica》《Hepatobiliary & Pancreatic Diseases International》《Chinese Medical Journal》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划山西省青年科技研究基金河北省自然科学基金更多>>

The Effect of Curcumin on Alzheimer’s Disease: 《Advances in Aging Research》2024年第6期136-148,共13页Waad Al-Twalah Noorah Saleh Al-Sowayan; Alzheimer’s disease (AD) is the most prevalent type of dementia, affecting approximately 50 million individuals globally, and projections indicate that this number will increase to 139 million by 2050. It is one of t...; 关键词：Alzheimer’s CURCUMIN BETA-AMYLOID ANTI-INFLAMMATORY Antioxidant MICROGLIA

The tip of the iceberg?The underestimated potential of non-canonical beta-amyloids for Alzheimer's disease: 《Neural Regeneration Research》2023年第12期2689-2690,共2页Lukas Busch Bernd Bufe; Ministerium für Wissenschaft und Gesundheit (MWG),Rheinland Pfalz,Neurodeg X Forschungskolleg (to BB)。; Formation and deposition of amyloid-beta(Aβ) are considered one of the main drivers of Alzheimer's disease(AD). For more than 30 years, Aβ has challenged researchers through its complex physicochemical properties an...; 关键词：AMYLOID ALZHEIMER Aβ

Liposome based drug delivery as a potential treatment option for Alzheimer’s disease被引量：6: 《Neural Regeneration Research》2022年第6期1190-1198,共9页Carely Hernandez Surabhi Shukla; Alzheimer’s disease is a neurodegenerative condition leading to atrophy of the brain and robbing nearly 5.8 million individuals in the United States age 65 and older of their cognitive functions.Alzheimer’s disease ...; 关键词：Alzheimer’s disease BETA-AMYLOID blood-brain barrier brain delivery drug delivery systems encapsulated drugs liposomes nanoparticles neurodegenerative diseases PEGYLATION targeted delivery tau

EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid: 《Translational Neurodegeneration》2022年第1期835-844,共10页Hannes Devos Kathleen Gustafson Ke Liao Pedram Ahmadnezhad Bradley Estes Laura E.Martin Jonathan D.Mahnken William M.Brooks Jeffrey M.Burns; the National Institute on Aging of the National Institutes of Health under Award Number K01 AG058785;This study was supported in part by a pilot grant of the KU Alzheimer Disease Center(P30 AG035982).; Background: Although growing evidence links beta-amyloid (Aβ) and neuronal hyperexcitability in preclinical mouse models of Alzheimer’s disease (AD), a similar association in humans is yet to be established. The fir...; 关键词：Event-related potentials Electro-encephalography Working memory Older adults PRECLINICAL BETA-AMYLOID

Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration被引量：16: 《Translational Neurodegeneration》2022年第1期917-930,共14页Manish Verma Britney N.Lizama Charleen T.Chu; Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system,acting to mediate excitatory neurotransmission.However,high levels of glutamatergic input elicit excitotoxicity,contribut...; 关键词：Mitochondrial calcium Mitochondrial calcium uniporter NCLX antiporter Parkinson’s disease Alzheimer’s disease LRRK2 PINK1 BETA-AMYLOID MITOPHAGY EXCITOTOXICITY Amyotrophic lateral sclerosis Huntington’s disease GLUCOCEREBROSIDASE

Small Molecular Weight Compounds Antagonistic to Amyloid Peptide<sub>25-35</sub>: 《Journal of Biosciences and Medicines》2021年第1期41-51,共11页W. Robert Williams; High levels of the neurotoxic beta-amyloid protein (Aβ) in patients with Alzheimer’s disease present a significant therapeutic target, although the protein is unlikely to be the sole instigator of this cond...; 关键词：Alzheimer’s Disease Beta-Amyloid Peptide Beta-Amyloid Antagonists Molecular Modeling

The relationship between the lymphatic system and Alzheimer's disease wasdiscussed based on the tri-jiao theory: 《TMR Theory and Hypothesis》2020年第3期362-367,共6页Zi-Yi Zhang; Type of the lymphatic system is a new concept put forward by foreign scholars in recent years.It is similar to the lymphatic system,is the brain of the internal fluid metabolism channel and its metabolites in the brai...; 关键词：Tri-jiao theory Glymphatic system Alzheimer's disease BETA-AMYLOID

Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives被引量：17: 《Translational Neurodegeneration》2020年第2期178-188,共11页Yuan Cheng Ding-Yuan Tian Yan-Jiang Wang; This review was supported by the National Natural Science Foundation of China(grant no.81930028,91749206,81625007 and 31921003).; Alzheimer’s disease(AD)is the most common type of dementia,and no disease-modifying treatments are available to halt or slow its progression.Amyloid-beta(Aβ)is suggested to play a pivotal role in the pathogenesis of...; 关键词：Alzheimer's disease BETA-AMYLOID Blood-brain barrier Lymphatic vessel Venous sinus PERIPHERY Liver Kidney Intestine Skin Blood MONOCYTE Enzymes

Can mouse models mimic sporadic Alzheimer’s disease?被引量：4: 《Neural Regeneration Research》2020年第3期401-406,共6页Bettina M.Foidl Christian Humpel; supported by the Austrian Science Funds(P24734-B24); Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common form of dementia worldwide.As age is the main risk factor,>97%of all AD cases are of sporadic origin,potentiated by various risk ...; 关键词：Alzheimer’s disease BETA-AMYLOID cerebral AMYLOID ANGIOPATHY cognitive impairment SPORADIC and genetic mouse models tau vascular risk factors

Mutations of beta-amyloid precursor protein alter the consequence of Alzheimer's disease pathogenesis被引量：8: 《Neural Regeneration Research》2019年第4期658-665,共8页Nuo-Min Li Ke-Fu Liu Yun-Jie Qiu Huan-Huan Zhang Hiroshi Nakanishi Hong Qing; funded by the National Natural Science Foundation of China,No.81671268(to HQ);partially supported by a grant from the Ministry of Science and Technology of China,No.2013YQ03059514(to HQ);a grant from Key Laboratory for Neurodegenerative Disease of Ministry of Education of China,No.2015SJBX05(to HQ),2015SJZS01(to HQ); Alzheimer's disease is pathologically defined by accumulation of extracellular amyloid-β(Aβ). Approximately 25 mutations in β-amyloid precursor protein(APP) are pathogenic and cause autosomal dominant Alzheimer's d...; 关键词：nerve REGENERATION Alzheimer’s disease Β-AMYLOID precursor protein amyloidβ APP MUTATIONS liquid chromatography-tandem mass CHROMATOGRAPHY cellular localization long Aβ neural REGENERATION

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