Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives  

作　　者：Yuan Cheng Ding-Yuan Tian Yan-Jiang Wang 

机构地区：[1]Department of Neurology and Centre for Clinical Neuroscience,Daping Hospital,Third Military Medical University,Chongqing,China [2]The Institute of Brain and Intelligence,Third Military Medical University,Chongqing,China [3]Key Laboratory of Aging and Brain Diseases,Chongqing,China [4]Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai,China

出　　处：《Translational Neurodegeneration》2020年第2期178-188,共11页转化神经变性病（英文）

基　　金：This review was supported by the National Natural Science Foundation of China(grant no.81930028,91749206,81625007 and 31921003).

摘　　要：Alzheimer’s disease(AD)is the most common type of dementia,and no disease-modifying treatments are available to halt or slow its progression.Amyloid-beta(Aβ)is suggested to play a pivotal role in the pathogenesis of AD,and clearance of Aβfrom the brain becomes a main therapeutic strategy for AD.Recent studies found that Aβclearance in the periphery contributes substantially to reducing Aβaccumulation in the brain.Therefore,understanding the mechanism of how Aβis cleared in the periphery is important for the development of effective therapies for AD.In this review,we summarized recent findings on the mechanisms of Aβefflux from the brain to the periphery and discuss where and how the brain-derived Aβis cleared in the periphery.Based on these findings,we propose future strategies to enhance peripheral Aβclearance for the prevention and treatment of AD.This review provides a novel perspective to understand the pathogenesis of AD and develop interventions for this disease from a systemic approach.

关 键 词：Alzheimer's disease BETA-AMYLOID Blood-brain barrier Lymphatic vessel Venous sinus PERIPHERY Liver Kidney Intestine Skin Blood MONOCYTE Enzymes 

分 类 号：R749.16[医药卫生—神经病学与精神病学]