EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid  

作　　者：Hannes Devos Kathleen Gustafson Ke Liao Pedram Ahmadnezhad Bradley Estes Laura E.Martin Jonathan D.Mahnken William M.Brooks Jeffrey M.Burns 

机构地区：[1]Department of Physical Therapy,Rehabilitation Science,and Athletic Training,University of Kansas Medical Center,Kansas City,KS 66160,USA [2]Department of Neurology,University of Kansas Medical Center,Kansas City,KS 66160,USA [3]Hoglund Biomedical Imaging Center,University of Kansas Medical Center,Kansas City,KS 66160,USA [4]Department of Population Health,University of Kansas Medical Center,Kansas City,KS 66160,USA [5]Department of Biostatistics and Data Science,University of Kansas Medical Center,Kansas City,KS 66160,USA [6]University of Kansas Alzheimer’s Disease Center,University of Kansas Medical Center,Kansas City,KS 66160,USA.

出　　处：《Translational Neurodegeneration》2022年第1期835-844,共10页转化神经变性病（英文）

基　　金：the National Institute on Aging of the National Institutes of Health under Award Number K01 AG058785;This study was supported in part by a pilot grant of the KU Alzheimer Disease Center(P30 AG035982).

摘　　要：Background: Although growing evidence links beta-amyloid (Aβ) and neuronal hyperexcitability in preclinical mouse models of Alzheimer’s disease (AD), a similar association in humans is yet to be established. The first aim of the study was to determine the association between elevated Aβ (Aβ+) and cognitive processes measured by the P3 event-related potential (ERP) in cognitively normal (CN) older adults. The second aim was to compare the event- related power between CNAβ+ and CNAβ−. Methods: Seventeen CNAβ+ participants (age: 73 ± 5, 11 females, Montreal Cognitive Assessment [MoCA] score 26 ± 2) and 17 CNAβ- participants group-matched for age, sex, and MOCA completed a working memory task (n-back with n = 0, 1, 2) test while wearing a 256-channel electro-encephalography net. P3 peak amplitude and latency of the target, nontarget and task difference effect (nontarget−target), and event-related power in the delta, theta, alpha, and beta bands, extracted from Fz, Cz, and Pz, were compared between groups using linear mixed models. P3 ampli-tude of the task difference effect at Fz and event-related power in the delta band were considered main outcomes. Correlations of mean Aβ standard uptake value ratios (SUVR) using positron emission tomography with P3 amplitude and latency of the task difference effect were analyzed using Pearson Correlation Coefficient r. Results: The P3 peak amplitude of the task difference effect at Fz was lower in the CNAβ+ group (P = 0.048). Simi-larly, power was lower in the delta band for nontargets at Fz in the CNAβ+ participants (P = 0.04). The CNAβ+ partici-pants also demonstrated higher theta and alpha power in channels at Cz and Pz, but no changes in P3 ERP. Strong correlations were found between the mean Aβ SUVR and the latency of the 1-back (r = − 0.69;P = 0.003) and 2-back (r = − 0.69;P = 0.004) of the task difference effect at channel Fz in the CNAβ+ group. Conclusions: Our data suggest that the elevated amyloid in cognitively normal older adults is associate

关 键 词：Event-related potentials Electro-encephalography Working memory Older adults PRECLINICAL BETA-AMYLOID 

分 类 号：R749.16[医药卫生—神经病学与精神病学]