PRECLINICAL

作品数：127被引量：278H指数：9
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Making bridges between preclinical and clinical insights into age-related cognitive decline
《Neural Regeneration Research》2025年第8期2321-2322,共2页David VC Brito Clévio Nóbrega 
Clévio Nóbrega’s laboratory is funded by the Cure CSB project;the Viljem Julijan Association for Children with Rare Diseases(Slovenia);the Algarve Biomedical Center Research Institute(ABC-Ri);funded by CRESC Algarve 2020(Operation Code:ALG-01-0145-FEDER-072586)(to CN)。
With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th...
关键词：BRIDGES BECOMING INSIGHT 
Preclinical ex vivo IL2RG gene therapy using autologous hematopoietic stem cells as an effective and safe treatment for X-linked severe combined immunodeficiency disease
《Genes & Diseases》2025年第3期397-410,共14页Mingfeng Hu Qiling Xu Fang Zhang Karen F.Buckland Yelei Gao Weixia Du Yuan Ding Lina Zhou Xiulian Sun Lijia Ma Zhiyong Zhang Xuemei Tang Xiaodong Zhao Adrian J.Thrasher Yunfei An 
supported by the National Natural Science Foundation of China(No.82070135);the National Key R&D Program of China(No.2021YFC2700804);the CQMU Program for Youth Innovation in Future Medicine(China)(No.W0100).
X-linked severe combined immunodeficiency disease(X-SCID)is a rare inheriteddisease caused by mutations in the interleukin 2 receptor subunit gamma gene(IL2RG),whichencodes the common g chain protein,a subunit of the ...
关键词：Atypicaldiverse phenotype Gene therapy IL2RG Self-inactivating lentiviral vector X-linked severe combined immunodeficiency disease 
Natural products and cancer: The urgent need to bridge the gap between preclinical and clinical research
《World Journal of Gastrointestinal Oncology》2025年第4期531-534,共4页Armando Rojas Ileana Gonzalez Miguel Angel Morales 
Any new report on the anticancer properties of natural products always awakens new satisfaction and hope about the role of the international scientific community in its continuous contributions to human health,particu...
关键词：Natural products Anticancer therapy Preclinical studies Clinical trials 
Advancements in proteogenomics for preclinical targeted cancer therapy research
《Biophysics Reports》2025年第1期56-76,共21页Yuying Suo Yuanli Song Yuqiu Wang Qian Liu Henry Rodriguez Hu Zhou 
financially supported by the National Key Research and Development Program(2022YFA1302902 to H.Z.);the Shanghai Municipal Science and Technology Major Project;supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0830000);the National Natural Science Foundation of China(22425703 to H.Z.)。
Advancements in molecular characterization technologies have accelerated targeted cancer therapy research at unprecedented resolution and dimensionality.Integrating comprehensive multi-omic molecular profiling of a tu...
关键词：PROTEOGENOMICS Targeted cancer therapy Integrated omics analysis 
Preclinical characterization of[^(18)F]D_(2)-LW223:an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa(TSPO)in neuroinflammatory rodent models and non-human primates
《Acta Pharmacologica Sinica》2025年第2期393-403,共11页Kai Liao Jia-hui Chen Jie Ma Chen-chen Dong Chun-yang Bi Ya-biao Gao Yuan-fang Jiang Tao Wang Hui-yi Wei Lu Hou Jun-qi Hu Jun-jie Wei Chun-yuan Zeng Yin-long Li Sen Yan Hao Xu Steven H.Liang Lu Wang 
supported by the National Natural Science Foundation of China(82071974,82371998);the Guangdong Science and Technology Planning Project,China(2022A0505050042);the Science and Technology Program of Guangzhou,China(202206010106,2023A03J0566);the Frontier Technology Program of the First Affiliated Hospital of Jinan University,China(JNU1AF-CFTP-2022-a01214).
Positron emission tomography(PET)targeting translocator protein 18 kDa(TSPO)can be used for the noninvasive detection of neuroinflammation.Improved in vivo stability of a TSPO tracer is beneficial for minimizing the p...
关键词：translocator protein 18 kDa TSPO D_(2)-LW223 NEUROINFLAMMATION PET ^(18)F 
Pinelliae Rhizoma:a systematic review on botany,ethnopharmacology,phytochemistry,preclinical and clinical evidence
《Chinese Journal of Natural Medicines》2025年第1期1-20,共20页Zuanji Liang Jinchao Wei Sioi Chan Siyuan Zhang Li Xu Chenxiao Shen Zhangfeng Zhong Yitao Wang 
funded by the Macao Science and Technology Development Fund(FDCT Nos.001/2023/ALC,0123/2022/A,0006/2020/AKP,and 005/2023/SKL);the Natural Science Foundation of Guangdong Province,China(No.2020A1515010922);the Shenzhen-Hong Kong-Macao S&T Program(Category C,No.SGDX2020110309420200);the Research Fund of University of Macao(Nos.MYRG-GRG2023-00198-ICMS,CPG2024-00038-ICMS and SRG2022-00052-ICMS)。
Pinelliae Rhizoma(PR),known as Banxia in Chinese,Hange in Japanese,and Banha in Korean,is a renowned herbal medicine in East Asia derived from the dry tuber of Pinellia ternata(Thunb.)Breit.(PT).It is extensively util...
关键词：Pinelliae Rhizoma Pinellia ternata Herbal medicine Classical prescription Dispensing granule 
Unwanted disorders and xenogeneic graft-versus-host disease in experimental immunodeficient mice:How to evaluate and how to report
《Animal Models and Experimental Medicine》2025年第1期20-29,共10页Seyed Mostafa Monzavi Samad Muhammadnejad Vahid Mansouri Hami Ashraf Naser Ahmadbeigi 
Human-derived tumor models are essential for preclinical development of new anti-cancer drug entities.Generating animal models bearing tumors of human origin,such as patient-derived or cell line-derived xenograft tumo...
关键词：animal models graft-versus-host disease health surveillance preclinical drug evaluation xenograft model antitumor assays 
Fast T_(1)mapping MRI in preclinical and clinical settings using subspace-constrained joint-domain reconstructions
《Magnetic Resonance Letters》2024年第4期12-24,共13页Lingceng Ma Qingjia Bao Ricardo P.Martinho Zhong Chen Lucio Frydman 
funded by the Israel Science Foundation(grants 3594/21 and 1874/22);the Clore Institute for High Field Magnetic Resonance Imaging and Spectroscopy and by the Azrieli Institute for Brain Imaging(Weizmann Institute),by China Scholarship Council(CSC)grant 201806310085;the National Key Research and Development Program grant 2023YFE0113300;the Magnetic Resonance Technology Alliance of the Chinese Academy of Sciences Scientific Research Instrument and Equipment Development Project grant 2021GZL001;the Israel Cancer Research Foundation and by Israel's Planning and Budget Committee(Lingceng Ma,international student fellowship).
This work aims to develop fast T_(1)mapping methods for preclinical and clinical scanners based on subspace-constrained reconstructions.Two sequences are explored for rapid T_(1)characterizations:1)Interleaved spatiot...
关键词：T_(1)mapping Subspace-constrained reconstructions IR GRE SPEN Dynamic contrast enhancement Pancreatic cancer 
Harnessing the power of artificial intelligence for human living organoid research
《Bioactive Materials》2024年第12期140-164,共25页Hui Wang Xiangyang Li Xiaoyan You Guoping Zhao 
supported by the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Projects(TSBICIP-CXRC-008);Strategic Priority Research Program of the Chinese Academy of Sciences(XDC 0110300);Major Project of Haihe Laboratory of Synthetic Biology(E2M9560201);National Natural Science Foundation of China(32301210&31200035);the China Postdoctoral Science Foundation(No.2022M713330).
As a powerful paradigm,artificial intelligence(AI)is rapidly impacting every aspect of our day-to-day life and scientific research through interdisciplinary transformations.Living human organoids(LOs)have a great pote...
关键词：Artificial intelligence Human living organoids Organoid intelligence In vitro miniature organ models Multidisciplinary techniques Preclinical-to-clinical transformation 
Potential therapeutic strategies for MASH: from preclinical to clinical development
《Life Metabolism》2024年第5期45-60,共16页Zhifu Xie Yufeng Li Long Cheng Yidan Huang Wanglin Rao Honglu Shi Jingya Li 
supported by grants from the National Natural Science Foundation of China(92057116 to J.L.;82170872 to Z.X.,and 82200965 to Y.L.);the Natural Science Foundation of Shanghai’s 2021“Science and Technology Innovation Action Plan”(21ZR1475300 to Z.X.);Shanghai Science and Technology Development Funds(22YF1456900 to Y.L.).
Current treatment paradigms for metabolic dysfunction-associated steatohepatitis(MASH)are based primarily on dietary restrictions and the use of existing drugs,including anti-diabetic and anti-obesity medications.Give...
关键词：STEATOSIS inflammation FIBROSIS metabolic dysfunction-associated steatohepatitis PHARMACOTHERAPY 
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