云南高校图书馆联盟文献共享服务平台- TSPO

TSPO: 作品数：54被引量：88H指数：4; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：苏新辉马超苏福王存祖李云峰更多>>; 相关机构：福建医科大学厦门大学军事医学科学院江苏大学附属医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金福建省医学创新课题王宽诚敎育基金国家重点基础研究发展计划更多>>

胶质细胞中TSPO的表达在神经退行性疾病中的作用: 《中国实用神经疾病杂志》2025年第2期257-260,共4页梁变变刘宏利李杨张天丽成晓婧张小冬; 自然科学研究面上项目(编号:202203021221299)。; 神经退行性疾病(NDDs)是一种神经系统疾病,其特点是中枢神经系统(CNS)或周围神经系统(PNS)神经元的进行性丧失。生物靶标转位蛋白18 kDa(TSPO)已被公认为是神经炎症的生物标志物,而神经炎症是当前神经退行性疾病研究的重要领域。在神经...; 关键词：反应性胶质细胞转位蛋白18 kDa 神经炎症神经退行性疾病

Preclinical characterization of[^(18)F]D_(2)-LW223:an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa(TSPO)in neuroinflammatory rodent models and non-human primates: 《Acta Pharmacologica Sinica》2025年第2期393-403,共11页Kai Liao Jia-hui Chen Jie Ma Chen-chen Dong Chun-yang Bi Ya-biao Gao Yuan-fang Jiang Tao Wang Hui-yi Wei Lu Hou Jun-qi Hu Jun-jie Wei Chun-yuan Zeng Yin-long Li Sen Yan Hao Xu Steven H.Liang Lu Wang; supported by the National Natural Science Foundation of China(82071974,82371998);the Guangdong Science and Technology Planning Project,China(2022A0505050042);the Science and Technology Program of Guangzhou,China(202206010106,2023A03J0566);the Frontier Technology Program of the First Affiliated Hospital of Jinan University,China(JNU1AF-CFTP-2022-a01214).; Positron emission tomography(PET)targeting translocator protein 18 kDa(TSPO)can be used for the noninvasive detection of neuroinflammation.Improved in vivo stability of a TSPO tracer is beneficial for minimizing the p...; 关键词：translocator protein 18 kDa TSPO D_(2)-LW223 NEUROINFLAMMATION PET ^(18)F

Synthesis and evaluation of TSPO-targeting radioligand[^(18)F]F-TFQC for PET neuroimaging in epileptic rats: 《Acta Pharmaceutica Sinica B》2025年第2期722-736,共15页Wenhui Fu Qingyu Lin Zhequan Fu Tingting Yang Dai Shi Pengcheng Ma Hongxing Su Yunze Wang Guobing Liu Jing Ding Hongcheng Shi Dengfeng Cheng; supported by the National Natural Science Foundation of China(No.82172002 and 82272058,China);Shanghai Municipal Science and Technology Committee of Shanghai Outstanding Academic Leaders Plan(No.21XD1423500,China);National Key Research and Development Program of China(No.2022YFC2406901).; The translocator protein(TSPO)positron emission tomography(PET)can noninvasively detect neuroinflammation associated with epileptogenesis and epilepsy.This study explored the role of the TSPO-targeting radioligand[^(1...; 关键词：FLUORINE-18 TSPO PET Epilepsy NEUROIMAGING

重型颅脑外伤围手术期S100β、Vaspin、TSPO变化及与病情转归关联性探究: 《医学检验与临床》2024年第12期36-40,共5页常圣雅刘婉玉郭佳; 目的:基于重型颅脑外伤患者围手术期S100钙结合蛋白β(S100β)、丝氨酸蛋白酶抑制剂(Vaspin)、转运蛋白(TSPO)水平变化,探究其对病情转归的预测价值。方法:选取2023年1月-2024年1月本院收治的73例重型颅脑外伤患者为研究对象,均接受传...; 关键词：重型颅脑外伤 S100钙结合蛋白β 丝氨酸蛋白酶抑制剂转运蛋白病情转归

Optimizing B^(+)-tree for hybrid memory with in-node hotspot cache and eADR awareness: 《Frontiers of Computer Science》2024年第5期133-145,共13页Peiquan JIN Zhaole CHU Gaocong LIU Yongping LUO Shouhong WAN; This paper was supported by the National Natural Science Foundation of China(Grant No.62072419).; he advance in Non-Volatile Memory(NVM)has changed the traditional DRAM-onlymemorysystem.Compared to DRAM,NVM has the advantages of nonvolatility and large capacity.However,as the read/write speed of NVM is still lower...; 关键词：hybrid memory B^(+)-tree hotspot in-node cache eADR

靶向TSPO分子探针^(18)F-FDPA和^(18)F-LW223用于兔腹主动脉粥样硬化易损斑块PET显像的对比研究: 《中华核医学与分子影像杂志》2024年第8期478-483,共6页李全牟甜甜张颖田毅贠明凯胡标张烨虹解小芬董薇米宏志; 国家自然科学基金(82102090)。; 目的比较靶向相对分子质量1.8×10^(4)转位蛋白(TSPO)的分子探针N,N-二乙基-2-[2-(4-^(18)F-氟苯基)-5,7-二甲基吡唑[1,5-a]并嘧啶-3-基]乙酰胺(^(18)F-FDPA)和^(18)F-(R)-(N-仲丁基)-3-氟甲基-N-甲基-4-苯基喹啉-2-甲酰胺(LW223)用于...; 关键词：斑块动脉粥样硬化主动脉腹受体 FDPA 氟放射性同位素正电子发射断层显像术兔

TSPO deficiency exacerbates acute lung injury via NLRP3 inflammasome-mediated pyroptosis: 《Chinese Medical Journal》2024年第13期1592-1602,共11页Jingyi Han Xue Zhang Menghua Cai Feng Tian Yi Xu Hui Chen Wei He Jianmin Zhang Hui Tian; National Natural Science Foundation of China(Nos.82071791,32270915,U20A20374,31970843,and 81972886);National Key Research and Development Program of China(No.2022YFC3602004);CAMS Initiative for Innovative Medicine(Nos.2021-I2M-1-005,2021-I2M-1-035,2021-I2M-1-053,and 2022-I2M-CoV19-007);Haihe Laboratory of Cell Ecosystem Innovation Fund(No.22HHXBSS00028);CAMS Central Public Welfare Scientific Research Institute Basal Research Expenses(No.3332020035);Changzhou Science and Technology Support Plan(No.CE20215008);Beijing Municipal Commission of Science and Technology Fund for Innovative Drugs(No.Z221100007922040); Background:Acute respiratory distress syndrome(ARDS)is a common cause of respiratory failure in many critically ill patients.Although inflammasome activation plays an important role in the induction of acute lung inju...; 关键词：Acute respiratory distress syndrome Acute lung injury 18-kDa translocator protein MACROPHAGE NLRP3 inflammasome Inflammation

Efficient concentration of trace analyte with ordered hotspot construction for a robust and sensitive SERS platform: 《International Journal of Extreme Manufacturing》2024年第3期532-542,共11页Youdi Hu Yanlei Hu Zhenyu Wang Jiale Yong Wei Xiong Dong Wu Shixiang Xu; National Natural Science Foundation of China(Nos.92050203,52122511,52305319,52375582);Shenzhen Fundamental Research Program(Nos.JCYJ20200109105606426,JCYJ20190808164007485)。; Surface-enhanced Raman scattering(SERS)platform,which enables trace analyte detection,has important application prospects.By structuring/modifying the surface of the SERSsubstrate,analyte in highly diluted solutions c...; 关键词：surface-enhanced Raman scattering anodic aluminium oxide femtosecond laser processing concentration of trace analytes mechanical robustness

miR-344b-3p靶向Tspo基因参与双酚S诱导的小鼠睾丸合成睾酮功能异常: 《宁夏医科大学学报》2024年第5期433-439,共7页孙胜琪姜晓周洋西刘晋祎杨惠芳曹佳; 国家重点研发计划项目(2022YFC2702902);重庆自然科学基金项目(cstc2021jcyj-msxmX0316)。; 目的探讨双酚S(bisphenol S,BPS)影响小鼠睾酮合成异常的作用及机制。方法构建浓度为0、2、10、50 mg·kg^(-1) BPS染毒小鼠模型,采用HE染色观察其睾丸组织的形态、计算机辅助精子分析系统(CASA)分析精子活力、ELISA检测血清睾酮水平的...; 关键词：双酚S 睾酮 miR-344b-3p 生殖损害

重型颅脑外伤围手术期FGL2、Vaspin、TSPO变化及与预后关联性研究: 《河南外科学杂志》2023年第6期34-37,共4页范雪君柴清喜李建军霍晓锋; 目的探讨重型颅脑外伤(SCI)围手术期血清纤维蛋白原样蛋白2(FGL2)、脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)、转运蛋白(TSPO)水平变化与预后的关联性。方法回顾性分析2020-03—2023-03于许昌市人民医院进行手术治疗的80例SCI患者的临床...; 关键词：重型颅脑外伤病情转归 FGL2 VASPIN TSPO

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