Β-AMYLOID

作品数：125被引量：423H指数：9
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相关领域：医药卫生更多>>
相关作者：王桂松张翼张珉张瑞洁刘安更多>>
相关机构：中南大学上海第二医科大学附属仁济医院北京大学复旦大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Benzothiazole-endoperoxide conjugates protect PC12 cells againstβ-amyloid-induced cell death via singlet oxygen mediated oxidative detoxification of fibrils
《Smart Molecules》2024年第2期111-118,共8页Hao Wu Lei Wang Xiao Qian Wanwan Wang Yu Si Rensong Sun Engin U.Akkaya 
supported by the National Natural Science Foundation of China(22178048,22007008);the LiaoNing Revitalization Talents Program(XLYC1902001,XLYC1907021);the Fundamental Research Funds for the Central Universities(DUT18RC(3)062,DUT19RC(3)009,DUT23YG120).
Metastable endoperoxides with beta-amyloid fibrils targeting benzothiazole moieties were designed and synthesized.Singlet oxygen released from these endoperoxides by thermal cycloreversion reaction was shown to cause ...
关键词：β-amyloid protein Alzheimer's disease BENZOTHIAZOLE ENDOPEROXIDES singlet oxygen 
Updates in Alzheimer’s disease:from basic research to diagnosis and therapies被引量：1
《Translational Neurodegeneration》2024年第1期409-456,共48页Enjie Liu Yao Zhang Jian-Zhi Wang 
supported in part by the Natural Science Foundation of China(82001134,1949205,31730035,81721005);the Guangdong Provincial Key S&T Program(018B030336001);the Natural Science Foundation of Henan(242300421081).
Alzheimer’s disease(AD)is the most common neurodegenerative disorder,characterized pathologically by extracellular deposition ofβ-amyloid(Aβ)into senile plaques and intracellular accumulation of hyperphosphorylated...
关键词：Alzheimer’s disease NEURODEGENERATION Tau Β-AMYLOID DIAGNOSIS Drug development 
Radiolabeled imaging agents for Alzheimer's disease
《iRADIOLOGY》2024年第1期80-95,共16页Jiajun Wu Kexin Li Jie Yang Meiting Mao Yan Cheng 
The Fundamental Research Funds for the Central Universities,and the Higher Education Discipline Innovation Project,Grant/Award Number:B18035;National Natural Science Foundation of Sichuan Province of China,Grant/Award Number:2023NSFSC1721。
Alzheimer's disease(AD)is a chronic and progressive neurodegenerative disorder with long preclinical and prodromal phases in older people.Molecular imaging is a promising approach for noninvasive in vivo identificatio...
关键词：Alzheimer's disease(AD) β-amyloid(Aβ) molecular probe NEUROINFLAMMATION positron emission tomography(PET) TAU 
Development of water-soluble AIE-based wash-free Aβprobes superior to commercial ThT被引量：1
《Journal of Innovative Optical Health Sciences》2023年第6期3-12,共10页Ting-Ting Hou Ying-Hao Tang Zhen-Yu Zhang Ze-Jun Li Ya-Long Wang 
supported by the National Key R&D Program of China(2021ZD0201004);the National Natural Science Foundation of China(22165008,22077037,21474034,51673077 and 51603078);Hainan Provincial Natural Science Foundation of China(521RC506);the Open Project Program of Wuhan National Laboratory for Optoelectronics(No.2020WNLOKF018)。
Alzheimer's disease(AD)is a typical neurodegenerative disease.β-amyloid(AβÞplaque is the most prominent pathological biomarker associated with the progression of AD.Conventional Aβprobes,including commercial probe ...
关键词：Β-AMYLOID aggregation-induced emission fluorescence imaging 
Neuroprotective effect of hydroxy-α-sanshool against β-amyloid-induced damage in differentiated PC12 cells
《Chinese Medical Journal》2023年第17期2140-2142,共3页Shufang Shan Siquan Zhou Guochen Ma Xiaoyu Wang Jingyuan Xiong Guo Cheng 
Department of Science and Technology of Sichuan Province(No.2021YJ0156);Active Health and Aging Technologic Solutions Major Project of National Key R&D Program(No.2020YFC2006300)
To the Editor:Alzheimer’s disease(AD)is a chronic neurodegenerative disorder that accounts for approximately 70%of global dementia cases and leads to cognitive and behavioral impairments.[1]Neuritic plaques and neuro...
关键词：protective AMYLOID PEROXIDATION 
Physiological Roles of β-amyloid in Regulating Synaptic Function:Implications for AD Pathophysiology被引量：1
《Neuroscience Bulletin》2023年第8期1289-1308,共20页Wenwen Cai Linxi Li Shaoming Sang Xiaoli Pan Chunjiu Zhong 
supported by grants from the Shanghai Municipal Science and Technology Major Project,the National Key Research and Development Program Foundation of China(2016YFC1306403);the National Natural Science Foundation of China(81870822,91332201,81901081,81600930,82171408,82171411);the Natural Science Foundation of Fujian Province(2020CXB049).
The physiological functions of endogenous amyloid-β(Aβ),which plays important role in the pathology of Alzheimer's disease(AD),have not been paid enough attention.Here,we review the multiple physiological effects o...
关键词：Aβ Physiological role SYNAPSE LTP Synaptic vesicle cycle COGNITION AD 
High-frequency terahertz waves disrupt Alzheimer’s β-amyloid fibril formation被引量：4
《eLight》2023年第1期85-93,共9页Wenyu Peng Zhi Zhu Jing Lou Kun Chen Yuanming Wu Chao Chang 
supported by Innovation Laboratory of Terahertz Biophysics;financially supported by the National Natural Science Foundation of China(Grants No.12225511,T2241002);the key innovative project in Shaanxi(No.2021ZDLSF02-02,2022KXJ-123);sponsored by Shanghai Rising-Star Program(No.23QA1404200).
The accumulation and deposition of amyloid can cause a variety of neurodegenerative diseases,including Alzheimer’s and Parkinson’s disease.The degradation or clearance of this accumulation is currently the most wide...
关键词：AMYLOID ALZHEIMER AΒ 
Multiple effects of polydopamine nanoparticles on Cu^(2+)-mediated Alzheimer's β-amyloid aggregation被引量：1
《Chinese Journal of Chemical Engineering》2023年第2期144-152,共9页Xueqing Chen Weiqun Gao Yan Sun Xiaoyan Dong 
funded by the National Natural Science Foundation of China (21978207 and 21621004);the Natural Science Foundation of Tianjin from Tianjin Municipal Science and Technology Commission (19JCZDJC36800)。
Deposition of β-amyloid protein(Aβ) is the main hallmark of Alzheimer's disease(AD), and it has been well recognized that Cu^(2+)-mediated Aβ aggregation plays a crucial role in AD pathological processes.Cu^(2+)bin...
关键词：Protein AGGREGATION NANOPARTICLES Photothermal therapy Reactive oxygen species Cu^(2+)chelator 
Cellular response toβ-amyloid neurotoxicity in Alzheimer's disease and implications in new therapeutics被引量：1
《Animal Models and Experimental Medicine》2023年第1期3-9,共7页Haolin Zhang Xianghua Li Xiaoli Wang Jiayu Xu Felice Elefant Juan Wang 
National Institute of Neurological Disorders and Stroke,Grant/Award Number:2RF1NS095799;National Natural Science Foundation of China,Grant/Award Number:31970044 and 91854115;Beijing University of Technology Faculty of Environment and Life Seed Funding,Grant/Award Number:049000513202。
β-Amyloid(Aβ)is a specific pathological hallmark of Alzheimer's disease(AD).Because of its neurotoxicity,AD patients exhibit multiple brain dysfunctions.Disease-modifying therapy(DMT)is the central concept in the de...
关键词：Alzheimer's disease(AD) astrocytes ENDOPEPTIDASE glutaminyl cyclase(QC) microglia p75 neurotrophin receptor(p75NTR) proteolysis targeting chimeras(PROTACs) β-Amyloid(Aβ) 
Significance of native PLGA nanoparticles in the treatment of Alzheimer’s disease pathology被引量：1
《Bioactive Materials》2022年第11期506-525,共20页Bibin Anand Qi Wu Maryam Nakhaei-Nejad Govindarajan Karthivashan Lyudmyla Dorosh Sara Amidian Abhishek Dahal Xiuju Li Maria Stepanova Holger Wille Fabrizio Giuliani Satyabrata Kar 
Alzheimer’s disease (AD) is believed to be triggered by increased levels/aggregation of β-amyloid (Aβ) peptides. At present, there is no effective disease-modifying treatment for AD. Here, we evaluated the therapeu...
关键词：Alzheimer’s disease Β-AMYLOID Nanoparticles NEUROPROTECTION Peptide aggregation 
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