Physiological Roles of β-amyloid in Regulating Synaptic Function:Implications for AD Pathophysiology  

作　　者：Wenwen Cai Linxi Li Shaoming Sang Xiaoli Pan Chunjiu Zhong 

机构地区：[1]Department of Neurology,Zhongshan Hospital,Fudan University,Shanghai 200032,China [2]Basic Medical College,Nanchang University,Nanchang 330031,China [3]State Key Laboratory of Medical Neurobiology,Institutes of Brain Science&Collaborative Innovation Center for Brain Science,Fudan University,Shanghai 200032,China

出　　处：《Neuroscience Bulletin》2023年第8期1289-1308,共20页神经科学通报（英文版）

基　　金：supported by grants from the Shanghai Municipal Science and Technology Major Project,the National Key Research and Development Program Foundation of China(2016YFC1306403);the National Natural Science Foundation of China(81870822,91332201,81901081,81600930,82171408,82171411);the Natural Science Foundation of Fujian Province(2020CXB049).

摘　　要：The physiological functions of endogenous amyloid-β(Aβ),which plays important role in the pathology of Alzheimer's disease(AD),have not been paid enough attention.Here,we review the multiple physiological effects of Aβ,particularly in regulating synaptic transmission,and the possible mechanisms,in order to decipher the real characters of Aβunder both physiological and pathological conditions.Some worthy studies have shown that the deprivation of endogenous Aβgives rise to synaptic dysfunction and cognitive deficiency,while the moderate elevation of this peptide enhances long term potentiation and leads to neuronal hyperexcitability.In this review,we provide a new view for understanding the role of Aβin AD pathophysiology from the perspective of physiological meaning.

关 键 词：Aβ Physiological role SYNAPSE LTP Synaptic vesicle cycle COGNITION AD 

分 类 号：R747.2[医药卫生—神经病学与精神病学]