Benzothiazole-endoperoxide conjugates protect PC12 cells againstβ-amyloid-induced cell death via singlet oxygen mediated oxidative detoxification of fibrils  

作　　者：Hao Wu Lei Wang Xiao Qian Wanwan Wang Yu Si Rensong Sun Engin U.Akkaya 

机构地区：[1]State Key Laboratory of Fine Chemicals,and Department of Pharmaceutical Science,School of Chemical Engineering,Dalian University of Technology,Dalian,China [2]Global Education Program for AgriScience Frontiers,Graduate School of Agriculture,Hokkaido University,Sapporo,Japan

出　　处：《Smart Molecules》2024年第2期111-118,共8页智能分子（英文）

基　　金：supported by the National Natural Science Foundation of China(22178048,22007008);the LiaoNing Revitalization Talents Program(XLYC1902001,XLYC1907021);the Fundamental Research Funds for the Central Universities(DUT18RC(3)062,DUT19RC(3)009,DUT23YG120).

摘　　要：Metastable endoperoxides with beta-amyloid fibrils targeting benzothiazole moieties were designed and synthesized.Singlet oxygen released from these endoperoxides by thermal cycloreversion reaction was shown to cause significant structural changes on the amyloid assemblies.Most importantly,the cytotoxicity of the beta-amyloid fibrils on the PC12 cells were significantly reduced in the presence of endoperoxides.This observation,coupled with the fact that neither external oxygen,nor light is needed for this transformation,is very promising.

关 键 词：β-amyloid protein Alzheimer's disease BENZOTHIAZOLE ENDOPEROXIDES singlet oxygen 

分 类 号：O62[理学—有机化学]