ENDOPEROXIDES

作品数：3被引量：1H指数：1
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相关作者：杨笛更多>>
相关机构：南京医科大学更多>>
相关期刊：《Science China Chemistry》《Smart Molecules》《CCS Chemistry》更多>>
相关基金：国家自然科学基金更多>>
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Benzothiazole-endoperoxide conjugates protect PC12 cells againstβ-amyloid-induced cell death via singlet oxygen mediated oxidative detoxification of fibrils
《Smart Molecules》2024年第2期111-118,共8页Hao Wu Lei Wang Xiao Qian Wanwan Wang Yu Si Rensong Sun Engin U.Akkaya 
supported by the National Natural Science Foundation of China(22178048,22007008);the LiaoNing Revitalization Talents Program(XLYC1902001,XLYC1907021);the Fundamental Research Funds for the Central Universities(DUT18RC(3)062,DUT19RC(3)009,DUT23YG120).
Metastable endoperoxides with beta-amyloid fibrils targeting benzothiazole moieties were designed and synthesized.Singlet oxygen released from these endoperoxides by thermal cycloreversion reaction was shown to cause ...
关键词：β-amyloid protein Alzheimer's disease BENZOTHIAZOLE ENDOPEROXIDES singlet oxygen 
Reversibly sensitizing-storing-releasing ^(1)O_(2) within a single platinum(Ⅱ)-acetylide-based metallacycle molecule via laser power modulation
《Science China Chemistry》2024年第2期604-611,共8页Ruyi Zhou Wen Lv Bo Li Bo Yu Sudi Zhang Yucheng Zhou Shujuan Liu Qiang Zhao 
supported by the National Natural Science Foundation of China (22075148,22161160318);the Natural Science Foundation of Jiangsu Higher Education Institutions of China(21KJB150013);the Youth Fund Project of Jiangsu Natural Science Foundation (BK20210583)。
Tumor hypoxia severely limits the therapeutic efficacy of photodynamic therapy(PDT) for solid tumors,which is highly dependent on tissue oxygen concentration.In this study,we developed a platinum(Ⅱ)-acetylide-based m...
关键词：METALLACYCLES singlet oxygen ENDOPEROXIDES near-infrared absorption synergistic treatment 
A Singlet Oxygen Reservoir Based on Poly-Pyridone and Porphyrin Nanoscale Metal-Organic Framework for Cancer Therapy被引量：1
《CCS Chemistry》2021年第5期1187-1202,共16页Bo-Ru Xie Chu-Xin Li Yun Yu Jin-Yue Zeng Ming-Kang Zhang Xiao-Shuang Wang Xuan Zeng Xian-Zheng Zhang 
This study was supported by the National Natural Science Foundation of China(nos.51833007,51873162,21721005,and 51690152).
Here,a methacrylate-modified pyridone derivative(mPYR)was loaded into a porphyrin nanoscale metal-organic framework(porphyrin-nMOF).Then,the loaded mPYR was further polymerized to obtain poly-pyridone(poly-mPYR)to for...
关键词：cancer ENDOPEROXIDES pyridone derivative metal-organic framework PHOTODYNAMICTHERAPY 
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