A Singlet Oxygen Reservoir Based on Poly-Pyridone and Porphyrin Nanoscale Metal-Organic Framework for Cancer Therapy  

作　　者：Bo-Ru Xie Chu-Xin Li Yun Yu Jin-Yue Zeng Ming-Kang Zhang Xiao-Shuang Wang Xuan Zeng Xian-Zheng Zhang 

机构地区：[1]Key Laboratory of Biomedical Polymers of Ministry of Education,Department of Chemistry,Wuhan University,Wuhan 430072

出　　处：《CCS Chemistry》2021年第5期1187-1202,共16页中国化学会会刊（英文）

基　　金：This study was supported by the National Natural Science Foundation of China(nos.51833007,51873162,21721005,and 51690152).

摘　　要：Here,a methacrylate-modified pyridone derivative(mPYR)was loaded into a porphyrin nanoscale metal-organic framework(porphyrin-nMOF).Then,the loaded mPYR was further polymerized to obtain poly-pyridone(poly-mPYR)to form poly-mPYR loaded porphyrin-nMOF,which is designated as PLP and used as a reservoir of singlet oxygen(^(1)O_(2)).It was found that PLP could quickly capture^(1)O_(2)in vitro and slowly release^(1)O_(2)in vivo to induce cancer cell death.The release of^(1)O_(2)was light and oxygen independent,and the entire process did not cause intracellular oxygen consumption.PLP also displayed good therapeutic effect in the treatment of both solid tumor and lung metastasis cancer.This strategy of oxygenand light-independent^(1)O_(2)treatment presents great potential for treating refractory cancer.Also,the form of^(1)O_(2)capturing polymer-loaded nMOF expands the biomedical applications of MOFs and polymers,which can be used as a platform for biomedical applications.

关 键 词：cancer ENDOPEROXIDES pyridone derivative metal-organic framework PHOTODYNAMICTHERAPY 

分 类 号：O62[理学—有机化学]