Reversibly sensitizing-storing-releasing ^(1)O_(2) within a single platinum(Ⅱ)-acetylide-based metallacycle molecule via laser power modulation  

作　　者：Ruyi Zhou Wen Lv Bo Li Bo Yu Sudi Zhang Yucheng Zhou Shujuan Liu Qiang Zhao 

机构地区：[1]State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors,Institute of Advanced Materials(IAM)&Institute of Flexible Electronics(Future Technology),Nanjing University of Posts and Telecommunications(NUPT),Nanjing,210023,China [2]College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology),Jiangsu Province Engineering Research Center for Fabrication and Application of Special Optical Fiber Materials and Devices,Nanjing University of Posts and Telecommunications(NUPT),Nanjing,210023,China

出　　处：《Science China Chemistry》2024年第2期604-611,共8页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (22075148,22161160318);the Natural Science Foundation of Jiangsu Higher Education Institutions of China(21KJB150013);the Youth Fund Project of Jiangsu Natural Science Foundation (BK20210583)。

摘　　要：Tumor hypoxia severely limits the therapeutic efficacy of photodynamic therapy(PDT) for solid tumors,which is highly dependent on tissue oxygen concentration.In this study,we developed a platinum(Ⅱ)-acetylide-based metallacycle compound bearing six 1,4-dimethylnaphthalenes(DMN) groups,and controlled the photodynamic and photothermal effects of the compound by adjusting the power of 730 nm laser to achieve reversible sensitization,storage and release of 1~O_(2) within a single molecule.The compound formed nanoparticles by self-assembly and exhibited good water solubility and biocompatibility.Under laser irradiation,the strong spin-orbit coupling of platinum atoms in the metallacycle facilitated 1~O_(2) generation.The produced 1~O_(2) was captured by the DMN carriers and transported into the hypoxic tumor,where 1~O_(2) release was triggered owing to the good photothermal effect of the extended conjugation of the metallacycle.During therapy,the metallacycle serving as a photosensitizer,1~O_(2) carrier,and photothermal reagent,achieved the synergistic therapy of PDT/PTT,demonstrating the versatility of the metallacycle.This study proposes a new strategy to develop phototherapy agents that are suitable for hypoxic tumors.

关 键 词：METALLACYCLES singlet oxygen ENDOPEROXIDES near-infrared absorption synergistic treatment 

分 类 号：TQ422[化学工程]