ENDOPEPTIDASE

作品数：17被引量：35H指数：3
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相关领域：生物学医药卫生更多>>
相关作者：芮琪徐朗莱张志刚李红涛赵昱更多>>
相关机构：南京农业大学哈尔滨工业大学天津科技大学南开大学更多>>
相关期刊：《Molecular Plant》《Journal of Integrative Plant Biology》《Chinese Journal of Chemical Engineering》《Science China Chemistry》更多>>
相关基金：国家自然科学基金国家教育部博士点基金更多>>
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Digesting gluten with oral endopeptidases to improve the management of celiac disease
《World Journal of Gastroenterology》2024年第26期3201-3205,共5页Katelin Durham Mirac Nedim Ince 
Supported by the VA Merit Award,2I01BX002906-05.
In our editorial,we want to comment on the article by Stefanolo et al titled“Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet”.Celiac disease is an imm...
关键词：Celiac disease Gluten-free diet ENDOPEPTIDASE Villous atrophy Aspergillus niger Adjunct therapy 
C/EBPβ/AEP Signaling Drives Alzheimer's Disease Pathogenesis被引量：3
《Neuroscience Bulletin》2023年第7期1173-1185,共13页Jing Xiong Zhentao Zhang Keqiang Ye 
supported by start-up funding from Shenzhen Institute of Advanced Technology;the National Natural Science Foundation of China(No.82271446).
Alzheimer’s disease(AD)is the most common type of dementia.Almost two-thirds of patients with AD are female.The reason for the higher susceptibility to AD onset in women is unclear.However,hormone changes during the ...
关键词：Alzheimer's disease C/EBPΒ Asparagine endopeptidase PATHOGENESIS Follicle stimulating hormone 
Cellular response toβ-amyloid neurotoxicity in Alzheimer's disease and implications in new therapeutics被引量：1
《Animal Models and Experimental Medicine》2023年第1期3-9,共7页Haolin Zhang Xianghua Li Xiaoli Wang Jiayu Xu Felice Elefant Juan Wang 
National Institute of Neurological Disorders and Stroke,Grant/Award Number:2RF1NS095799;National Natural Science Foundation of China,Grant/Award Number:31970044 and 91854115;Beijing University of Technology Faculty of Environment and Life Seed Funding,Grant/Award Number:049000513202。
β-Amyloid(Aβ)is a specific pathological hallmark of Alzheimer's disease(AD).Because of its neurotoxicity,AD patients exhibit multiple brain dysfunctions.Disease-modifying therapy(DMT)is the central concept in the de...
关键词：Alzheimer's disease(AD) astrocytes ENDOPEPTIDASE glutaminyl cyclase(QC) microglia p75 neurotrophin receptor(p75NTR) proteolysis targeting chimeras(PROTACs) β-Amyloid(Aβ) 
Pharmacological inhibition of asparaqinyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer's disease-related pathologies in a senescence-accelerated mouse model
《Translational Neurodegeneration》2021年第1期140-149,共10页Ju Wang Hui-Jie Hu Zi-Kai Liu Jing-Jing Liu Shan-Shan Wang Qing Cheng Hong-Zhuan Chen Mingke Song 
supported by the National Natural Science Foundation of China(81671375,91949116 and 81873807);Innovative Research Team of High-level Local Universities in Shanghai,China.
Background:Currently,there is no cure for Alzheimer's disease(AD).Therapeutics that can modify the early stage of AD are urgently needed.Recent studies have shown that the pathogenesis of AD is closely regulated by an...
关键词：Alzheimer's disease Asparaginyl endopeptidase LEGUMAIN SAMP8 mouse δ-Secretase inhibitor 11 Therapeutic target 
Successive digestion of tilapia collagen by serine proteinase and proline specific endopeptidase to produce novel angiotensin l-converting enzyme inhibitory peptides被引量：1
《Marine Life Science & Technology》2020年第3期268-278,共11页Xin Hua Lechang Sun Chan Zhong Qiang Wu Panpan Xiao Asami Yoshida Guangming Liu Minjie Cao 
This work was sponsored by the National Key R&D Program of China(2018YFD0901004);the National Natural Scientific Foundations of China(31471640,31702372).
Serine proteinase,purified from the hepatopancreas of Pacific white shrimp(Litopenaeus vannamei), was used to hydrolyze acid solubilized collagen(ASC)isolated from Nile tilapia(Oreochromis sp.)skin to produce angioten...
关键词：Serine proteinase Purification COLLAGEN ACE inhibitory peptides Hypertension Lowering blood pressure 
Peptide asparaginyl ligases——renegade peptide bond makers被引量：2
《Science China Chemistry》2020年第3期296-307,共12页James P.Tam Ning-Yu Chan Heng Tai Liew Shaun J.Tan Yu Chen 
supported by Academic Research Grant Tier 3(MOE2016-T3-1-003)from the Singapore Ministry of Education.
Making peptide bonds is tightly controlled by genetic code and machinery which includes cofactors,ATP,and RNAs.In this regard,the stand-alone and genetic-code-independent peptide ligases constitute a new family of ren...
关键词：asparaginyl ENDOPEPTIDASE Asn-specific LIGATION bioorthogonal LIGATION butelase CHEMOENZYMATIC LIGATION live-cell LABELING PROTEIN engineering PROTEIN modification site-specific LABELING tandem LIGATION 
Childhood chronic gastritis and duodenitis: Role of altered sensory neuromediators被引量：2
《World Journal of Gastroenterology》2016年第37期8349-8360,共12页Ali Islek Aygen Yilmaz Gulsum Ozlem Elpek Nuray Erin 
Supported by Akdeniz University Research Unit,Antalya,Turkey,No.2012.01.0103.012
AIM To investigate the roles of the neuropeptides vasoactive intestinal peptide(VIP), substance P(SP), and calcitonin gene-related peptide(CGRP) in chronic gastritis and duodenitis in children.METHODS Biopsy samples f...
关键词：GASTRITIS NEUROPEPTIDES CHILDHOOD Neutral ENDOPEPTIDASE 
Activity Gel Analysis of Endopeptidases in Rose Petals
《Horticultural Plant Journal》2016年第2期114-120,共7页ZHAO Xiting ZHANG Changqing ZHU Yuting LI Tianzhong GAO Junping 
supported by grants from the National Natural Science Foundation of China(30972025,31372105)
Poor resolution for the identification of endopeptidase(EP) activity in activity gel assays is a critical issue in the analysis of the postharvest physiology of rose petals. In this paper, major factors influencing EP...
关键词：ROSE petal ENDOPEPTIDASE activity gel 
Identification in Lupin Seed of a Serine- Endopeptidase Activity Cleaving between Twin Arginine Pairs and Causing Limited Proteolysis of Seed Storage Proteins
《Molecular Plant》2012年第5期1011-1019,共9页Chiara Magni Fabio Sessa Gabriella Tedeschi Armando Negri Alessio Scarafoni Alessandro Consonni Marcello Duranti 
The occurrence of twin-arginine motifs （-R-R-） in the amino acid sequences of animal pro-proteins frequently defines the cleavage site（s） for their structural/functional maturation. No information is available on ...
关键词：Lupinus albus leguminous seeds twin-arginine residues PROTEOLYSIS storage proteins proteolytic conver-sion N-terminal amino acid sequence analysis. 
Senescence-Related Endopeptidase Isozymes in Spirodela polyrrhiza Half-fronds Detected by Gel Electrophoresis被引量：3
《Agricultural Science & Technology》2010年第1期31-32,106,共3页刘清岱 王金菊 李红涛 赵昱 张治州 
Supported by New Century Excellent Talents Project of the Ministry of Education (2006);Talents Introduction Fund of Tianjin University of Science and Technology (20060432 and 20080216)~~
[Objective]To study endopeptidases in Spirodela polyrrhiza half-fronds during senescence and their characters. [Method]Changes in endopeptidase isoenzymes of the Spirodela polyrrhiza half-fronds during senescence were...
关键词：Spirodela polyrrhiza Half-fronds SENESCENCE ENDOPEPTIDASE 
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