云南高校图书馆联盟文献共享服务平台- LEGUMAIN

LEGUMAIN: 作品数：29被引量：33H指数：4; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：林森南开辉李彤谢佩玲段朝晖更多>>; 相关机构：温州医科大学南开大学天津医科大学上海交通大学更多>>; 相关期刊：《生命科学研究》《广东医学》《中国癌症杂志》《现代中西医结合杂志》更多>>; 相关基金：国家自然科学基金深圳市科技计划项目深圳市医学重点学科建设基金广东省自然科学基金更多>>

Legumain/TRAF6通路在肾脏缺血-再灌注损伤中的作用研究: 《中国医药指南》2024年第23期17-20,共4页高帅方潇戴天增周智华; 福建省卫健委青年课题(2020QNB039)。; 目的本研究旨在探讨Legumain/TRAF6通路在肾脏缺血-再灌注损伤中的作用机制。方法将50只SPF级C57BL/6小鼠随机分为5组,每组10只,A组:假手术组,B组:模型组,C组:Legumain低表达,D组:Legumain低表达+TRAF6过表达组,E组:Legumain低表达+TRAF...; 关键词：肾脏缺血-再灌注损伤 Legumain/TRAF6通路作用机制

Legumain-triggered aggregable gold nanoparticles for enhanced intratumoral retention被引量：1: 《Chinese Chemical Letters》2024年第7期388-393,共6页Zhi Li Wenpei Li Shaoping Jiang Chuan Hu Yuanyu Huang Maxim Shevtsov Huile Gao Shaobo Ruan; supported by the Beijing Natural Science Foundation(No.L222128);Beijing Institute of Technology Research Fund Program for Young Scholars(No.XSQD-202121010);National Natural Science Foundation of China(No.81961138009)。; Insufficient intratumoral retention of nanomedicines remains the major challenge for broad implementation in clinical sets.Herein,we proposed a legumain-triggered aggregable gold nanoparticle(GNP)delivery platform(GNP...; 关键词：LEGUMAIN Size-tunable Enhanced retention Stimulus-responsive NANOMEDICINE

Cas9 mRNA与gRNA在乳腺癌细胞中编辑LGMN基因的作用研究: 《广东化工》2023年第24期55-59,共5页王越彭保卫; Legumain(或天冬氨酸内肽酶/AEP)是一种溶酶体半胱氨酸内肽酶,与多种癌症的侵袭和迁移行为增加相关。本研究通过设计Legumain(或AEP)特异性g RNA,构建了含有双U6启动子的g RNA质粒;构建了含T7启动子的g RNA质粒,优化RNA体外转录纯化方...; 关键词：CRISPR/Cas9 基因编辑 Legumain/AEP IVT

Self-oriented central-tumor delivery of legumain-cleavable vehicles governed by circulating monocyte/macrophage for precise tumor enrichment and immune activation被引量：1: 《Nano Research》2023年第4期5189-5205,共17页Fangying Yu Xuwei Shang Yun Zhu Lijun Peng Simin Chen Tingting Meng Hong Yuan Fuqiang Hu; supported by Zhejiang Provincial Natural Science Foundation of China(No.D19H300001).; Compressed blood and intratumoral lymphatic vessels induced by proliferated tumor cells and elevated interstitial fluid pressure produce regional hypoxic and necrotic region within tumors,which severely reduced the ac...; 关键词：self-oriented circulating monocyte/macrophage hitchhike legumain-sensitive vehicles precise central-tumor enrichment immune activation

Legumain在肿瘤微环境中的作用: 《中国细胞生物学学报》2022年第9期1830-1837,共8页康瑾薛凯凯范雅荣张晓龙张清董丽刘小春; 山西省自然科学基金(批准号:201901D211135);山西省高等学校科技创新项目(批准号:201802009);山西省出国留学人员专项(批准号:2021-020)资助的课题。; 肿瘤微环境是肿瘤发生发展过程中重要的决定因素,受到细胞内多种蛋白质表达量异常或结构改变的影响。LGMN(Legumain)是一种半胱氨酸蛋白酶,参与多种蛋白质的加工,在体内发挥一定的生物学功能。同时LGMN在多种实体瘤中高表达,与恶性肿瘤...; 关键词：LEGUMAIN 肿瘤微环境生物学机制

Legumain酶和线粒体双级靶向去氢骆驼蓬碱脂质体的制备及其体外特性评价被引量：1: 《中国药房》2022年第13期1565-1572,共8页伊帕尔古丽·阿皮孜贺宏吉王昭志李喆喆卡迪热娅·艾克拉木白静雅王梅; 国家自然科学基金资助项目(No.81760637);新疆维吾尔自治区天山英才计划第三期资助项目;新疆天然活性组分和释药技术重点实验室项目(No.XJDX1713);新疆医科大学大学生创新训练计划项目(No.CX2021048)。; 目的制备Legumain酶和线粒体双级靶向去氢骆驼蓬碱(HM)脂质体(KA@HM-LPS),并对其制剂学特性、体外抗肿瘤作用及生物相容性进行初步评价。方法首先,筛选KA@HM-LPS的制备方法和均质化方法,并对制备的脂质体进行表征。其次,分别测定KA@HM-...; 关键词：去氢骆驼蓬碱线粒体 Legumain酶脂质体

Genetically-engineered“all-in-one”vaccine platform for cancer immunotherapy被引量：2: 《Acta Pharmaceutica Sinica B》2021年第11期3622-3635,共14页Aihua Wu Yingzhi Chen Hairui Wang Ya Chang Meng Zhang Pengfei Zhao Yisi Tang Qin Xu Zhuangzhi Zhu Yang Cao Yongzhuo Huang; support of National Key Research and Development Program of China(2021YFE0103100,China);National Natural Science Foundation of China of China(81925035,81673382,and 81521005,China);National Special Project for Significant New Drugs Development(2018ZX09711002-010-002,China);Shanghai SciTech Innovation Initiative(19431903100,18430740800,China);Shanghai Collaborative Innovation Group of Early Diagnosis and Precise Treatment of Hemangiomas and Vascular Malformations(SSMU-ZDCX20180701,China);Chinese Pharmaceutical Association-Yiling Pharm Joint Grants(CPAYLJ201901,China)for the support。; An essential step for cancer vaccination is to break the immunosuppression and elicit a tumor-specific immunity.A major hurdle against cancer therapeutic vaccination is the insufficient immune stimulation of the cance...; 关键词：TRICHOSANTHIN LEGUMAIN TRP2 Transcutaneous immunization ADJUVANT Cancer vaccine Protein engineering

Legumain-induced intracerebrally crosslinked vesicles for suppressing efflux transport of Alzheimer’s disease multi-drug nanosystem: 《Bioactive Materials》2021年第6期1750-1764,共15页Fuxin Jiang Jian Ren Yachai Gao Jinna Wang Yiping Zhao Fengying Dai; This work was financially sponsored by the National Natural Science Foundation of China(Nos.51773152);the Science and Technology Plans of Tianjin(15JCYBJC17900);the Natural Science Foundation of Tianjin(18JCYBJC17500).; Brain barrier is both a protective permeability hurdle and a limitation site where therapeutic agents are excluded to enter the target region.Designing drug vehicle to overcome this notorious barrier bottle is challen...; 关键词：LEGUMAIN Brain barrier Efflux transport Multi-drug delivery Alzheimer’s disease

胰腺癌中Legumain的表达及其对胰腺癌细胞增殖和迁移的影响: 《临床与实验病理学杂志》2021年第4期402-407,共6页张波王正峰朱骏严俊陈浩斐张宝腾周文策; 甘肃省科技重点研发计划资助课题(17YF1FA128);兰州市人才创新创业项目资助课题(2017-RC-37)。; 目的探讨Legumain(LGMN)在胰腺癌组织和细胞中的表达、意义及其下调对胰腺癌AsPC-1细胞增殖和迁移的影响。方法采用免疫组化SP法检测LGMN蛋白在67例胰腺癌组织及61例癌旁组织中的表达;分析LGMN表达与胰腺癌临床病理特征的关系。采用RT-...; 关键词：胰腺肿瘤 LEGUMAIN 增殖迁移免疫组织化学

Pharmacological inhibition of asparaqinyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer's disease-related pathologies in a senescence-accelerated mouse model: 《Translational Neurodegeneration》2021年第1期140-149,共10页Ju Wang Hui-Jie Hu Zi-Kai Liu Jing-Jing Liu Shan-Shan Wang Qing Cheng Hong-Zhuan Chen Mingke Song; supported by the National Natural Science Foundation of China(81671375,91949116 and 81873807);Innovative Research Team of High-level Local Universities in Shanghai,China.; Background:Currently,there is no cure for Alzheimer's disease(AD).Therapeutics that can modify the early stage of AD are urgently needed.Recent studies have shown that the pathogenesis of AD is closely regulated by an...; 关键词：Alzheimer's disease Asparaginyl endopeptidase LEGUMAIN SAMP8 mouse δ-Secretase inhibitor 11 Therapeutic target

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