云南高校图书馆联盟文献共享服务平台- TRICHOSANTHIN

TRICHOSANTHIN: 作品数：64被引量：78H指数：6; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：乔玉峰王林华姜国勇郭立忠徐丽丽更多>>; 相关机构：中国科学院山西医科大学青岛农业大学中国药科大学更多>>; 相关期刊：《青岛农业大学学报（自然科学版）》《Chinese Journal of Chemistry》《Cellular & Molecular Immunology》《Science China(Life Sciences)》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金美国国家科学基金更多>>

The use of miR122 and its target sequence in adeno-associated virus-mediated trichosanthin gene therapy被引量：2: 《Journal of Integrative Medicine》2021年第6期515-525,共11页Gai Ran Xi-lin Feng Yi-lin Xie Qing-yun Zheng Peng-peng Guo Ming Yang Ying-lu Feng Chen Ling Li-qing Zhu Chen Zhong; supported by the China Postdoctoral Science Foundation(No.2019M651381);the Shanghai Talent Development Funding(No.2019115)to Chen Zhong。; Objective:Plant-derived cytotoxic transgene expression,such as trichosanthin(tcs),regulated by recombinant adeno-associated virus(r AAV)vector is a promising cancer gene therapy.However,the cytotoxic transgene can ham...; 关键词：TRICHOSANTHIN miR122 target sequence Recombinant adeno-associated virus vector Gene therapy Liver cancer

Genetically-engineered“all-in-one”vaccine platform for cancer immunotherapy被引量：2: 《Acta Pharmaceutica Sinica B》2021年第11期3622-3635,共14页Aihua Wu Yingzhi Chen Hairui Wang Ya Chang Meng Zhang Pengfei Zhao Yisi Tang Qin Xu Zhuangzhi Zhu Yang Cao Yongzhuo Huang; support of National Key Research and Development Program of China(2021YFE0103100,China);National Natural Science Foundation of China of China(81925035,81673382,and 81521005,China);National Special Project for Significant New Drugs Development(2018ZX09711002-010-002,China);Shanghai SciTech Innovation Initiative(19431903100,18430740800,China);Shanghai Collaborative Innovation Group of Early Diagnosis and Precise Treatment of Hemangiomas and Vascular Malformations(SSMU-ZDCX20180701,China);Chinese Pharmaceutical Association-Yiling Pharm Joint Grants(CPAYLJ201901,China)for the support。; An essential step for cancer vaccination is to break the immunosuppression and elicit a tumor-specific immunity.A major hurdle against cancer therapeutic vaccination is the insufficient immune stimulation of the cance...; 关键词：TRICHOSANTHIN LEGUMAIN TRP2 Transcutaneous immunization ADJUVANT Cancer vaccine Protein engineering

Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo被引量：14: 《Journal of Integrative Medicine》2014年第6期483-494,共12页Yuan-hui Zhang Yuan Wang Ali Hussein Yusufali Frederick Ashby Daniel Zhang Zi-fei Yin George V.Aslanidi Arun Srivastava Chang-quan Ling Chen Ling; supported in part by the Alex’s Lemonade Foundation and the Bankhead-Coley Cancer Research Program, 3BN04, Florida Department of Health;Public Health Service Grants R01 HL-097088 and R21 EB-015684 from the National Institutes of Health;an institutional grant from the Children’s Miracle Network;the National Natural Science Foundation of China grant No. 81273881; OBJECTIVE： Little effort has been made to study the protein-encoding genes isolated from traditional Chinese medicine（TCM） drugs, and the delivery of these genes into malignant cells through recombinant adeno-assoc...; 关键词：medicine Chinese traditional cytotoxic genes trichosanthin recombinant adenoassociated virus vector cancer gene therapy

Using Xe as a heavy atom for phase determination of protein trichosanthin structure: 《Nuclear Science and Techniques》2014年第3期60-64,共5页陈亚星李敏军郁峰刘科徐春艳孙波周欢徐琴何建华; Supported by the Major State Basic Research Development Project in China(No.2011CB911102);National Natural Science Foundation of China(Nos.31000389,31100528 and 31100529); Under gas pressures of 1–3 MPa, xenon can be bound to discrete sites in hydrophobic cavities of protein,so as to use Xe as a heavy atom for determining phases in protein crystallography. Using single anomalous scatte...; 关键词：蛋白质重原子花粉结构天花粉蛋白氙相位气体压力反常散射

Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM被引量：12: 《Cellular & Molecular Immunology》2011年第4期359-367,共9页Yuchan Cai Shudao Xiong Yijie Zheng Feifei Luo Pei Jiang Yiwei Chu; the National Key Technologies R&D Program of China during the Eleventh Five-Year Plan Period(2009ZX10004-104 and 2009ZX09301-011);National Science Foundation of China(30872378 and 81072408);the Science and Technology Commission of Shanghai Municipality(10JC1401100)in China and National 973 Project(2010CB912603 and 2011CB910400)in China.We thank the editors of Editage Company for professional editing of the article.; Trichosanthin(TCS),extracted from the Chinese medicinal herb Trichosanthes kirilowi,has shown promise for the inhibition of tumor growth.However,its immunomodulatory effect on tumor–host interaction remains unknown.I...; 关键词：anti-tumor immunity CRTAM immune protection TRICHOSANTHIN TSLC1

The anti-viral protein of trichosanthin penetrates into human immunodeficiency virus type 1被引量：6: 《Acta Biochimica et Biophysica Sinica》2010年第2期91-97,共7页Wenlong Zhao Du Feng Shan Sun Ting Han Senfang Sui; Trichosanthin （TCS） is a type I ribosome-inactivating protein with potent inhibitory activity against human immunodeficiency virus type 1, and has been clinically applied in acquired immunodeficiency syndrome （AIDS...; 关键词：TRICHOSANTHIN ribosome-inactivating protein human immunodeficiency virus type 1 virus-like particle membrane penetration

Correlation Questions Clinical Discussion of Uterine Artery Embolization in Induced Abortion Patients with Management of Cesarean Scar Pregnancy: 《Journal of Reproduction and Contraception》2009年第3期153-160,共8页Ai-hua FAHG Qin-fang CHEN Zao-xia QIAN Qun-ying LI Yu MENG; Objective To analyze retrospectively the utility of uterine arterial embolization （UAE） for cesarean scar pregnancy （CSP）.Methods Fifty-one women with CSP were pretreated with UAE before dilatation ＆ curettage （...; 关键词：uterine artery embolization TRICHOSANTHIN MTX cesarean scar pregnancy dilatation curettage

Trichosanthin functions as Th2-type adjuvant in induction of allergic airway inflammation被引量：1: 《Cell Research》2009年第8期962-972,共11页Yuan Wang Kairui Mao Shuhui Sun Guomei Lin Xiaodong Wu Gang Yao Bing Sun; Acknowledgments We thank ProfYongjun Liu, Dangsheng Li and Yangxin Fu for helpful comments and Dr Sheri Skinner for reviewing the manuscript and for constructive suggestions. This work was supported by grants from the National Natural Science Foundation of China （30530700, 30623003, 30600568, 30721065, 90713044, 30600308, 30801011, 30870126） and CAS project （KSCX1-YW-R-43）, grant from SIBS project （2007KIP301）, grants from the Ministry of Science and Technology （2006CB504300, 2007CB512404, 2006AA02A247, 20072714）, the Technology Commission of Shanghai Municipality （88014199, 07DZ22916, 07XD14033, 064319034, 08431903004, 2008ZX10206, 08DZ2291703）, EU project （FP6-2005-SSP-5-B, SP5B-CT-2006-044161） and from the E-institutes of Shanghai Universities Immunology Division.; It is important to understand the pathogenesis of asthma induced by natural allergens, which could exclude the interference of artificial adjuvant and provide insights of natural immune response in the disease. In the...; 关键词：TCS TH2 airway inflammation ADJUVANT IL-4 EOSINOPHILS

Clinical Analysis of 45 Cases of Caesarean Scar Pregnancy被引量：4: 《Journal of Reproduction and Contraception》2008年第2期101-106,共6页Hong SHI Ai-hua FANG Qin-fang CHEN; Objective To summarize the clinical characteristics of caesarean scar pregnancy and to investigate its treatment.Methods Clinical case records of 45 cases of caesarean scar pregnancy from June 2003 to September 2007 w...; 关键词：caesarean scar pregnancy uterine artery embolization TRICHOSANTHIN

Crystallization and Preliminary Crystallographic Analysis of β-Trichosanthin,an Isoform of Trichosanthin from the Root Tuber of Trichosanthe kirilowii: 《Chinese Journal of Structural Chemistry》2007年第11期1303-1307,共5页侯晓敏陈明晃彭奇陈荔清 Meehan Edward J 黄明东; the NNSF of China (No.39970872,No.30772587);the Natural Science Foundation of Fujian Province (C97052,C0510012);Special Fund of Fujian Development and Reform Commission;the National Science Foundation of USA; β-Trichosanthin, a type 1 ribosome-inactivating protein （RIP） isolated from the root tuber of Trichosanthe kirilowii Maxim, is an isoform of trichosanthin. Here we report its crystallization in two crystal forms us...; 关键词：ribosome-inactivating protein ISOFORM TRICHOSANTHIN CRYSTALLIZATION

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