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作品数：129被引量：497H指数：10
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相关机构：华南农业大学山东大学河南省农业科学院广西医科大学更多>>
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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis被引量：1
《Neural Regeneration Research》2025年第4期1103-1123,共21页Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng Chen 
supported by the Natural Science Fund of Fujian Province,No.2020J011058(to JK);the Project of Fujian Provincial Hospital for High-level Hospital Construction,No.2020HSJJ12(to JK);the Fujian Provincial Finance Department Special Fund,No.(2021)848(to FC);the Fujian Provincial Major Scientific and Technological Special Projects on Health,No.2022ZD01008(to FC).
Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological damage.Hypoxic preconditioning has been shown to impr...
关键词：bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria NEUROINFLAMMATION oxidative stress PYROPTOSIS reactive oxygen species 
Oncogenic activation of PIK3CA in cancers:Emerging targeted therapies in precision oncology
《Genes & Diseases》2025年第2期143-153,共11页Yuxiang Wang Valery Rozen Yiqing Zhao Zhenghe Wang 
supported by the National Institutes of Health (USA)grantsSR01CA196643,R01CA264320,R01CA260629,P50CA150964,and P30CA043703 to Zhenghe Wang.
Phosphoinositide 3-kinases(PI3Ks)are heterodimers consisting of a p110 catalytic subunit and a p85 regulatory subunit.The PlIK3CA gene,which encodes the p110a,is the most frequently mutated oncogene in cancer.Oncogeni...
关键词：Hotspot mutation Isoform/mutant-specific inhibitors Metabolism PIK3CA Tumor microenvironment 
Isoform-and cell-state-specific APOE homeostasis and function被引量：2
《Neural Regeneration Research》2024年第11期2456-2466,共11页Karina Lindner Anne-Claude Gavin 
supported by the financial support of the Louis-Jeantet Foundation(to ACG).
Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling.It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing...
关键词：Alzheimer’s disease apolipoprotein E autophagy CHOLESTEROL lipid detoxification lipid transport lysosomal failure metabolic impairment TRIACYLGLYCEROL 
Quercetin inhibits truncated isoform of dopamine-and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer
《Food Science and Human Wellness》2024年第5期2653-2667,共15页Han-Sheng Chang Tzu-Chun Cheng Shih-Hsin Tu Chih-Hsiung Wu You-Cheng Liao Jungshan Chang Min-Hsiung Pan Li-Ching Chen Yuan-Soon Ho 
The National Science and Technology Council of Taiwan funded this study.
Trastuzumab resistance is one of the causes of poor prognosis in patients with human epidermal growth factor receptor 2(HER2)-positive(HER2+)breast cancer(BC).The truncated isoform of dopamine-and cAMPregulated phosph...
关键词：p95-Human epidermal growth factor receptor 2 (HER2) HER2-positive breast cancer QUERCETIN Trastuzumab resistance Truncated isoform of dopamine-and cAMPregulated PHOSPHOPROTEIN 
miR-933 accelerates the growth of liver cancer cells by enhancing pyruvate kinase isoform M2
《Genes & Diseases》2024年第4期31-34,共4页Liyan Wang Shujie Li Xinlei Liu Sijie Xie Shuting Song Xiaoxue Jiang Dongdong Lu 
supported by grants from the National Natural Science Foundation of China(No.82073130);the Science and Technology Commission of Shanghai Municipality Shanghai Science and Technology Plan Basic Research Field Project(China)(No.20JC1411400).
MicroRNAs(miRNAs)have been found to play an important role in human tumorigenesis.A study indicates that the plasma level of miR-933 was elevated in patients with dementia.1 Notably,miR-933(RS79402775)may contribute t...
关键词：ELEVATED CANCER LIVER 
The cytosolic isoform of triosephosphate isomerase,ZmTPI4,is required for kernel development and starch synthesis in maize(Zea mays L.)
《The Crop Journal》2024年第2期401-410,共10页Wenyu Li Han Wang Qiuyue Xu Long Zhang Yan Wang Yongbiao Yu Xiangkun Guo Zhiwei Zhang Yongbin Dong Yuling Li 
supported by the Major Public Welfare Projects of Henan Province(201300111100 to Yuling Li);Zhongyuan Scholars in Henan Province(22400510003 to Yuling Li);Tackle Program of Agricultural Seed in Henan Province(2022010201 to Yuling Li);Technical System of Maize Industry in Henan Province(HARS-2202-S to Yuling Li);State Key Laboratory of Wheat and Maize Crop Science(SKL2023ZZ05)。
Triosephosphate isomerase(TPI)is an enzyme that functions in plant energy production,accumulation,and conversion.To understand its function in maize,we characterized a maize TPI mutant,zmtpi4.In comparison to the wild...
关键词：MAIZE Kernel STARCH Weight PHOTOSYNTHESIS 
Development of PI3Kγselective inhibitors:the strategies and application
《Acta Pharmacologica Sinica》2024年第2期238-247,共10页Dong-yan Gu Meng-meng Zhang Jia Li Yu-bo Zhou Rong Sheng 
supported by the National Natural Science Foundation of China(82003780).
Theγisoform of Class I PI3Ks(PI3Kγ)is primarily found in leukocytes and is essential for the function of myeloid cells,as it regulates the migration,differentiation,and activation of myeloid-lineage immune cells.Thu...
关键词：PI3K PI3Kγinhibitors isoform selectivity drug development rational drug design 
Truncated SCRIB isoform promotes breast cancer metastasis through HNRNP A1 mediated exon 16 skipping
《Acta Pharmacologica Sinica》2023年第11期2307-2321,共15页Bin Zhang Shao-han Xie Jun-yi Hu Si-jia Lei Liang-hua Shen Hong-tao Liu Qing Zheng Zhi-ming Zhang Chun-lian Wu Qiang Li Feng Wang 
supported by the Guangzhou Basic and Applied Basic Research Project(to FW);Natural Science Foundation of Guangdong Province(NO.2022A1515012636);High-level University Construction Project and 2019 Ministry of Education“Chunhui Plan”Cooperative Scientific Research Project(NO.131).
Breast cancer is one of the most common malignant tumors with high mortality due to metastases. SCRIB, a scaffold protein mainly distributed in the cell membrane, is a potential tumor suppressor. Mislocalization and a...
关键词：breast cancer scribble planar cell polarity protein(SCRIB) HnRNP A1 alternative splicing invasion ASO-SCRIB 
Enrichment of novel Tau isoform with altered biochemical properties in Alzheimer's disease被引量：1
《Neural Regeneration Research》2023年第11期2397-2398,共2页Chin-Tong Ong 
supported by core funding provided by Temasek Life Sciences Laboratory (to CTO)。
Aberrant splicing in sporadic Alzheimer’s disease:Alzheimer’s disease (AD) is a progressive neurodegenerative disorder cha racterized by the presence of extracellular amyloid-β plaques and Tau-containing intracellu...
关键词：ALZHEIMER IMPAIRED 
Supervillin isoform 4(SV4)通过增强Aurora A活性调控细胞有丝分裂
《中国生物化学与分子生物学报》2023年第11期1588-1597,共10页毕文旭 张思钰 李抒洋 王薇 陈学冉 方志友 
国家自然科学基金项目(No.31571433;No.81773131)资助。
有丝分裂是真核生物进行细胞增殖的主要方式,染色体复制与准确分离对于有丝分裂的顺利进行至关重要。Supervillin是一种细胞膜与微丝肌动蛋白结合蛋白质,前期研究发现,其通过调控F-肌动蛋白、肌球蛋白II在细胞分裂过程中的皮层分布动态...
关键词：SUPERVILLIN Aurora A 中心体 有丝分裂 微管 
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