Isoform-and cell-state-specific APOE homeostasis and function  

作　　者：Karina Lindner Anne-Claude Gavin 

机构地区：[1]Department of Cell Physiology and Metabolism,Faculty of Medicine,University of Geneva,Geneva,Switzerland [2]Diabetes Center,Faculty of Medicine,University of Geneva,Geneva,Switzerland

出　　处：《Neural Regeneration Research》2024年第11期2456-2466,共11页中国神经再生研究（英文版）

基　　金：supported by the financial support of the Louis-Jeantet Foundation(to ACG).

摘　　要：Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling.It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them.Apolipoprotein E polymorphism,combined with environmental stresses and/or age-related alterations,influences the risk of developing late-onset Alzheimer’s disease.In this review,we discuss our current knowledge of how apolipoprotein E homeostasis,i.e.its synthesis,secretion,degradation,and lipidation,is affected in Alzheimer’s disease.

关 键 词：Alzheimer’s disease apolipoprotein E autophagy CHOLESTEROL lipid detoxification lipid transport lysosomal failure metabolic impairment TRIACYLGLYCEROL 

分 类 号：R749.16[医药卫生—神经病学与精神病学]