Enrichment of novel Tau isoform with altered biochemical properties in Alzheimer's disease  

作　　者：Chin-Tong Ong 

机构地区：[1]Temasek Life Sciences Laboratory,and Department of Biological Sciences,National University of Singapore,Singapore

出　　处：《Neural Regeneration Research》2023年第11期2397-2398,共2页中国神经再生研究（英文版）

基　　金：supported by core funding provided by Temasek Life Sciences Laboratory (to CTO)。

摘　　要：Aberrant splicing in sporadic Alzheimer’s disease:Alzheimer’s disease (AD) is a progressive neurodegenerative disorder cha racterized by the presence of extracellular amyloid-β plaques and Tau-containing intracellular neurofib rilla ry tangles (Knopman et al.,2021).Cognitive decline in AD due to neuronal and synaptic loss is caused by the complex interplay between pathological amyloid-β and Tau species with the impaired innate clearance pathways.There are two types of AD based on disease aetiology (Knopman et al.,2021).

关 键 词：ALZHEIMER IMPAIRED 

分 类 号：R749.16[医药卫生—神经病学与精神病学]