ADJUVANT

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Study on the Immune Activity of Mice In Vitro and In Vivo with Nano-Material Adjuvant
《Journal of Clinical and Nursing Research》2025年第4期356-362,共7页Qiran Wang 
This paper investigates the effects of graphene quantum dots and mesoporous silica as nanomaterial adjuvants on immune activity in mice both in vitro and in vivo.The two materials have distinct properties;graphene qua...
关键词：Graphene quantum dots Mesoporous silica Nanomaterial adjuvant Immune activity Immune regulation 
Double-metal ion adjuvant stabilized Pickering emulsion to amplify humoral and cellular immune responses
《Nano Research》2025年第3期360-371,共12页Zhaofei Guo Fuhua Wu Yanhua Xu Xue Tang Xiejin Xie Rui Hu Yangsen Ou Hongjiao Wei Lin Ye Chunting He Penghui He Hairui Wang Guangsheng Du Xun Sun 
supported by the National Key Research and Development Program of China(No.2023YFC2307700);the National Natural Science Foundation of China(Nos.U24A20811 and 82341038);the Program Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System(No.SCCXTD-2025-18);the 111 project(No.B18035);the Fundamental Research Funds for the Central Universities.
Metal ions play critical roles in many immune processes,and their modulation may open up new forms of vaccine adjuvants.Current vaccines predominantly utilize aluminum salts as adjuvants,but alum has poor ability to i...
关键词：Pickering nanoemulsion bimetallic adjuvant cGAS-STING vaccine 
Immunotherapy and liver transplantation for hepatocellular carcinoma:Current and future challenges
《World Journal of Transplantation》2025年第2期8-29,共22页Theodoros Pettas Sofia Lachanoudi Filippos F Karageorgos Ioannis A Ziogas Asimina Fylaktou Vassilios Papalois Georgios Katsanos Nikolaos Antoniadis Georgios Tsoulfas 
Despite existing curative options like surgical removal,tissue destruction techniques,and liver transplantation for early-stage hepatocellular carcinoma(HCC),the rising incidence and mortality rates of this global hea...
关键词：Hepatocellular carcinoma IMMUNOTHERAPY Liver transplantation Neoadjuvant and adjuvant immunotherapy Immune checkpoint inhibitors Vaccine therapies Oncolytic viruses Adoptive cell therapy Antigen-targeting antibodies Diagnostic biomarkers 
Clinical efficacy and safety of vortioxetine as an adjuvant drug for patients with bipolar depression
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第1期26-38,共13页Chunxiao DAI Yaoyang FU Xuanwei LI Meihua LIN Yinbo LI Xiao LI Keke HUANG Chengcheng ZHOU Jian XIE Qingwei ZHAO Shaohua HU 
partially supported by the Construction Fund of Key Medical Disciplines of Hangzhou(No.OO2020491);the National Key Research and Development Program of China(No.2023YFC2506200);the Zhejiang Provincial Key Research and Development Program(No.2021C03107);the Research Project of Jinan Microecological Biomedicine Shandong Laboratory(No.JNL-2023001B);the Leading Talent of Scientific and Technological Innovation-“Ten Thousand Talents Program”of Zhejiang Province(No.2021R52016);the Innovation Team for Precision Diagnosis and Treatment of Major Brain Diseases(No.2020R01001);the Chinese Medical Education Association(No.2022KTZ004).
Objective:Whether vortioxetine has a utility as an adjuvant drug in the treatment of bipolar depression remains controversial.This study aimed to validate the efficacy and safety of vortioxetine in bipolar depression....
关键词：BipolarⅡdepression LURASIDONE Vortioxetine COMBINATION 
Intraperitoneal Instillation of Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine for Postoperative Pain in Laparoscopic Cholecystectomy, a Randomized Clinical Trial
《Open Journal of Anesthesiology》2025年第1期1-12,共12页Ayman Mohamady Eldemrdash Zaher Z. Zaher Tarek S. Hemaida Taha T. Dardeer Hani M. Raslan Shawky M. Abdelgalil Mohmed R. Saad Mohammed S. Aly 
Background: Intraperitoneal instillation (IPI) of local anesthesia was reported to reduce postoperative pain after laparoscopic surgeries. We aim to evaluate the effectiveness of IPI of bupivacaine + dexmedetomidine v...
关键词：BUPIVACAINE DEXMEDETOMIDINE DEXAMETHASONE Laparoscopic Cholecystectomy 
A phase 2 pilot study of umbilical cord blood infusion as an adjuvant consolidation therapy in elderly patients with acute myeloid leukemia
《Signal Transduction and Targeted Therapy》2025年第1期384-393,共10页Jinzeng Wang Xiaoyang Li Ping Liu Yao Dai Hongming Zhu Yunxiang Zhang Min Wu Yunying Yao Mingzhu Liu Shuting Yu Fangying Jiang Shuai Wang Haoran Mu Bo Jiao Hua Yan Wen Wu Yang Shen Junming Li Shengyue Wang Ruibao Ren 
supported by the Shanghai Science and Technology Development Funds(No.20Z11900200 to R.R.);Key Project of National Natural Science Foundation of China(No.82230088 to R.R.);National Key Research and Development Program of China(No.2019YFA0905900 to J.L.;No.2019YFA0905902 to S.W.),National Natural Science Foundation of China(No.82170147 to R.R.;No.82370157 to J.L.;No.81970134 and 82170111 to P.L.);Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research(No.2019CXJQ01 to R.R.);the Samuel Waxman Cancer Research Foundation(to R.R.).
Acute myeloid leukemia(AML)is an aging-related malignancy,with patients aged≥60 years old facing significantly poorer prognosis.Umbilical cord blood(UCB)has emerged as a promising source with effective anti-aging rol...
关键词：INFUSION PATIENTS ADJUVANT 
Toward sustainable supply of vaccine adjuvant via synthetic biology
《Green Carbon》2024年第4期421-422,共2页Meijie Li Xinglin Jiang Yongjin J.Zhou Jianming Yang 
supported by grants from the National Natural Science Foundation of China(Grant no.22278233);the Natural Science Foundation of Shandong Province,China(ZR2022QB143);Novo Nordisk Fonden(NNF20CC0035580);the State Key Laboratory of Microbial Technology Open Projects Fund(M2022-07).
Adjuvants increase the efficacy of vaccines by stimulating or boosting the human immune response.QS-21 is a potent vaccine adjuvant extracted from the tree bark of Quillaja saponaria(QS)and is currently the only sapon...
关键词：ADJUVANT vaccines stimulating 
Neoadjuvant oncolytic virus orienx010 and toripalimab in resectable acral melanoma:a phase Ib trial
《Signal Transduction and Targeted Therapy》2024年第12期5777-5785,共9页Jiayong Liu Xuan Wang Zhongwu Li Shunyu Gao Lili Mao Jie Dai Caili Li Chuanliang Cui Zhihong Chi Xinan Sheng Yumei Lai Zhichao Tan Bin Lian Bixia Tang Xieqiao Yan Siming Li Li Zhou Xiaoting Wei Juan Li Jun Guo Lu Si 
supported by the National Key Research and Development Program(2023YFC2506404);National Natural Science Foundation of China(82372869,82272676,and 82073011);Beijing Municipal Administration of Hospitals’Ascent Plan(DFL20220901,QML20231107);Beijing Natural Science Foundation(7242021).
Neoadjuvant PD-1 inhibitor is promising in cutaneous melanoma but remains unknown in acral melanoma(AM).This phase Ib trial study(Clinicaltrials.gov NCT04197882)assessed the efficacy and safety of the combination of n...
关键词：ADJUVANT MELANOMA surgery 
Immunogenicity Evaluation of a SARS-CoV-2 BA.2 Subunit Vaccine Formulated with CpG 1826 plus alum Dual Adjuvant
《Biomedical and Environmental Sciences》2024年第12期1409-1420,共12页Yuhan Yan Qiudong Su Yao Yi Liping Shen Shengli Bi 
funded by the National Key R&D Program of China(2023YFC2605302).
Objective The present study aimed to evaluate the immunogenicity of BA.2 variant receptor binding domain(RBD)recombinant protein formulated with CpG 1826 plus alum dual adjuvant.Methods The BA.2 variant RBD(residues 3...
关键词：SARS-CoV-2 RBD Subunit vaccine ADJUVANT IMMUNOGENICITY 
GFPBW1,aβ-glucan from Grifola frondosa as vaccine adjuvant:APCs activation and maturation
《Acta Pharmacologica Sinica》2024年第11期2394-2404,共11页Xiang He Jiang-ling Lu Wen-feng Liao Yi-ru Long Xing Zhang Qian Zhu Heng-lei Lu Geng-yan Hao Kan Ding Jian-hua Sun Li-kun Gong Yi-fu Yang 
supported by the National Natural Science Foundation of China(82341039);the National Key Research and Development Plan(2022YFC2304105);Shanghai Municipal Science and Technology Major Project,the Science and Technology Innovation Action Plan of Shanghai(22S11902100,22140900500);the National Science Foundation for Distinguished Young Scholars of China(32271332);supported by the Zhongshan Municipal Bureau of Science and Technology(CXTD2023010);Department of Science and Technology of Guangdong Province(High-level Innovative Research Institute 2021B0909050003).
Adjuvants for vaccines with characteristics of improving adaptive immunity particularly via leverage of antigen presenting cells(APCs)are currently lacking.In a previous work we obtained a new soluble 300 kDa homogene...
关键词：cancer vaccine ADJUVANT granola frondose polysaccharide GFPBW1 Β-GLUCAN 
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