Toward sustainable supply of vaccine adjuvant via synthetic biology  

作　　者：Meijie Li Xinglin Jiang Yongjin J.Zhou Jianming Yang 

机构地区：[1]Energy-rich Compound Production by Photosynthetic Carbon Fixation Research Center,Shandong Key Lab of Applied Mycology,College of Life Sciences,Qingdao Agricultural University,No.700 Changchen Road,Qingdao 266109,China [2]State Key Laboratory of Microbial Technology,Shandong University,Qingdao 266237,China [3]The Novo Nordisk Foundation Center for Biosustainability,Technical University of Denmark,Kemitorvet Bygning 220,Lyngby 2800 Kgs.,Denmark [4]Division of Biotechnology,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China

出　　处：《Green Carbon》2024年第4期421-422,共2页绿碳(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(Grant no.22278233);the Natural Science Foundation of Shandong Province,China(ZR2022QB143);Novo Nordisk Fonden(NNF20CC0035580);the State Key Laboratory of Microbial Technology Open Projects Fund(M2022-07).

摘　　要：Adjuvants increase the efficacy of vaccines by stimulating or boosting the human immune response.QS-21 is a potent vaccine adjuvant extracted from the tree bark of Quillaja saponaria(QS)and is currently the only saponin-based adjuvant approved for use in human vaccines.Over the past 25 years,QS-21 has been tested and validated in over 120 clinical trials and has now been approved for GSK’s malaria(Mosquirix),shingles(Shingrix)vaccines and Novavax’s COVID-19 vaccines.

关 键 词：ADJUVANT vaccines stimulating 

分 类 号：R53[医药卫生—内科学]