PROTEOLYSIS

作品数：93被引量：248H指数：7
导出分析报告
相关作者：田妍夏凯李莉杜海宁梅子青更多>>
相关机构：武汉大学国家杂交水稻工程技术研究中心中南大学湖南农业大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
ZIF-90-loaded DNAzyme-responsive PROTAC for the self-powered degradation of NF-κB
《Science China Chemistry》2025年第2期687-693,共7页Min Hou Liang Sun Tianyu Ren Mingda Li Chao Hu Rong Liu Shuang Gu Mingyan Jiang Jian-Hui Jiang Jianjun He 
supported by the National Natural Science Foundation of China(NSFC)Programs(22204046);the Hunan Science Fund for Excellent Young Scholars(2023JJ20002);the National Key Research Program(2019YFA0905800);the Changsha Municipal Natural Science Foundation(kq2402088);the Scientific Research Fund of Hunan Provincial Education Department(22B0874,23B0844).
Transcription factors(TFs)play vital roles in regulating gene expressions.Dysregulated or mutated TFs are implicated in a wide array of diseases,highlighting their potential as drug targets.However,TFs are considered ...
关键词：inducible proteolysis DNAZYME transcription factor ZIF-90 NF-ΚB 
Virtual screening and directional preparation of xanthine oxidase inhibitory peptides derived from hemp seed protein
《Food Science and Human Wellness》2024年第6期3652-3660,共9页Xiaoni Huang Jiajun Liao Ping Shi Xiaodong Pei Chenghua Wang 
funded by National Natural Science Foundation of China(21868003);Bama County Program for Talents in Science and Technology(BaRenKe20210045).
The traditional nutritional and medical hemp(Cannabis sativa L.)seed protein were explored for the discovery and directional preparation of new xanthine oxidase inhibitory(XOI)peptides by structure-based virtual scree...
关键词：Hemp seed protein Anti-gout Bioactive peptide Virtual screening PROTEOLYSIS 
Exogenous Beta-guanidinopropionic acid administration enhances electromyostimulation-induced mitochondrial biogenesis in rat skeletal muscle
《Translational Exercise Biomedicine》2024年第3期295-304,共10页Naoki Fukao Junya Takegaki Ryo Takagi Koki Okumura Satoshi Fujita 
supported by JSPS KAKENHI Grant Number JP21KK0177 to SF.
Objectives Exercise training induces several skeletal muscle adaptations.Beta-guanidinopropionic acid(β-GPA)is a creatine analog that simulates the effect of exercise to induce mitochondrial biogenesis.However,the ef...
关键词：PGC-1Α AMPK OXPHOS CALCINEURIN muscle proteolysis 
Targeted degradation of LRG1 to attenuate renal fibrosis被引量：1
《Asian Journal of Pharmaceutical Sciences》2024年第4期144-158,共15页Linyao Fan Yingqiu Qi Xi Yang Yarui Xu Yana Zhang Longdi Wang Anying Zhu Lirong Zhang Jian Song Shengnan Du Guangjun Nie Huan Min 
supported by grants from the National Natural Science Foundation of China(32000998,32201240,and 81700638);The Young Elite Scientists Sponsorship Program by the Henan Association for Science and Technology(2022HYTP046);the China Postdoctoral Science Foundation(2021TQ0298).
Leucine-richα-2 glycoprotein 1(LRG1),a secreted glycoprotein,has been identified as significantly upregulated in renal fibrosis,potentially exacerbating the condition by enhancing TGF-β-Smad3-dependent signaling pat...
关键词：LRG1 Renal fibrosis Proteolysis targeting chimera Targeting peptide 
Elucidation of potential relationship between endogenous proteases and key flavor substances in dry-cured pork coppa
《Food Science and Human Wellness》2024年第4期2152-2160,共9页Mingming Li Qiujin Zhu Chao Qu Xiaohui Gong Yunhan Zhang Xin Zhang Shouwei Wang 
financially supported by the National Natural Science Foundation of China(32001728,32172248);the Taishan Industrial Experts Program;the Guizhou High-level Innovative Talent Training Project(Qianke Cooperation Platform Talent number[2016]5662);Guizhou Science and Technology Innovation Talent Team of Ecological Characteristic Meat Products.(QKHPTRC[2020]5004)。
Dry-cured meat products are considerably popular around the world due to unique flavor.Proteolysis is one of the enzymatic reactions from which flavor substances are derived,which is affected by endogenous proteases.T...
关键词：Dry-cured pork coppa Endogenous proteases PROTEOLYSIS Key taste-active amino acids Volatile compounds 
Foodborne toxin Aflatoxin B_(1)induced glomerular podocyte inflammation through proteolysis of RelA,downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway
《Food Science and Human Wellness》2024年第4期2289-2309,共21页Jie Zhang Shuang Yang Baocai Xu Zihui Qin Xinyi Guo Ben Wei Qinghua Wu Kamil Kuca Tushuai Li Wenda Wu 
funded by Suzhou Science and Technology Council(SNG201907);Universities Natural Science Foundation of Jiangsu Province(20KJB330002);General Program of China Postdoctoral Science Foundation(2022M711369);the Startup Funding of Soochow University,Jiangsu Province-Suzhou Science and Technology Planning Project(SL T201917);National Natural Science Foundation of China(32172922,31972741);Natural Science Foundation of Jiangsu Province of China(BK20211216,BK20221091);the Startup Funding of Hefei University of Technology(1302003712022058);China-CEEC Joint University Education Project(202010);the Excellence Project PrF UHK(2217/2022-2023)。
Aflatoxin B_(1)(AFB_(1))is a naturally-occurring mycotoxin and recognized as the most toxic foodborne toxin,particularly causing damages to kidney.Glomerular podocytes are terminally differentiated epithelial cells.AF...
关键词：Aflatoxin B_(1) Podocyte inflammation miRNA-9 Chemokine(C-X-C motif)receptor 4 RelA ubiquitin-dependent degradation 
Impact of sourdough fermentation on nutrient transformations in cereal-based foods:Mechanisms,practical applications,and health implications
《Grain & Oil Science and Technology》2024年第2期124-132,共9页Zhen Wang Luyang Wang 
supported by the Graduate Education Innovation and Quality Improvement Project of Henan University(No.SYLYC2023185).
Sourdough is often considered a healthy choice and quality improver for use in cereal production due to its unique microbial composition and fermentation properties.During sourdough fermentation of cereals,biotransfor...
关键词：Sourdough fermentation Lactic acid bacteria PROTEOLYSIS Starch hydrolysis Low-GI NUTRIENTS 
Expanding the horizons of targeted protein degradation:A non-small molecule perspective
《Acta Pharmaceutica Sinica B》2024年第6期2402-2427,共26页Xiaowei Huang Fengbo Wu Jing Ye Lian Wang Xiaoyun Wang Xiang Li Gu He 
supported by grants from the National Natural Science Foundation of China(22177084,82273559,82103757 and 82073473);the China Postdoctoral Science Foundation(2022M722283);PostDoctor Research Project,West China Hospital,Sichuan University(2023HXBH076,China);Sichuan Natural Science Foundation Project(2023NSFSC1554,China);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21036,China).
Targeted protein degradation(TPD)represented by proteolysis targeting chimeras(PROTACs)marks a significant stride in drug discovery.A plethora of innovative technologies inspired by PROTAC have not only revolutionized...
关键词：Targeted protein degradation Proteolysis targeting chimera ENDOCYTOSIS Autophagy Proximity-inducing modality Post-translational modification 
Applications and prospects of cryo-EM in drug discovery被引量：2
《Military Medical Research》2023年第6期848-861,共14页Kong-Fu Zhu Chuang Yuan Yong-Ming Du Kai-Lei Sun Xiao-Kang Zhang Horst Vogel Xu-Dong Jia Yuan-Zhu Gao Qin-Fen Zhang Da-Ping Wang Hua-Wei Zhang 
funded by the National Natural Science Foundation of China (NSFC, 31900046, 81972085, 82172465 and 32161133022);the Guangdong Provincial Key Laboratory of Advanced Biomaterials (2022B1212010003);the National Science and Technology Innovation 2030 Major Program (2022ZD0211900);the Shenzhen Key Laboratory of Computer Aided Drug Discovery (ZDSYS20201230165400001);the Chinese Academy of Science President’s International Fellowship Initiative (PIFI)(2020FSB0003);the Guangdong Retired Expert (granted by Guangdong Province);the Shenzhen Pengcheng Scientist;NSFC-SNSF Funding (32161133022);Alpha Mol&SIAT Joint Laboratory;Shenzhen Government Top-talent Working Funding and Guangdong Province Academician Work Funding。
Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time-and effort-consuming. Structural biology has been de...
关键词：Cryo-electron microscopy(cryo-EM) Drug discovery Structure-based drug design Fragment-based drug discovery Proteolysis targeting chimeras Drug repurposing Artificial intelligence(AI) 
Characterization of SARS-COV-2 main protease inhibitory peptides from Ulva prolifera proteins
《Journal of Oceanology and Limnology》2023年第5期1887-1899,共13页Zhiyong LI Yehua WANG Caiwei FU Dongren ZHANG Tuanjie CHE Songdong SHEN 
Supported by the National Key R&D Program of China (No.2016YFC1402102);the National Natural Science Foundation of China (No.41976109);the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)。
The main protease(M^(pro))is essential for the replication of SARS-COV-2 and therefore represents a promising anti-viral target.In this study,we screened M^(pro)inhibitory peptides from Ulva prolifera protein on in-si...
关键词：M^(pro)inhibitory peptide Ulva prolifera protein in-silico proteolysis immunomodulatory peptide gastrointestinal digestion transport study 
全选清除导出
共10页<12345678910>
检索报告 对象比较 聚类工具 使用帮助 返回顶部