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以碳量子点为荧光信号的生物传感器构建及其在金银花Pb^(2+)检测中的应用: 《轻工学报》2025年第2期72-79,共8页李浩佳贺诗华曹艺泽郭西玉朱由余赵玮钦黄淳; 国家自然科学基金青年基金资助项目(52102051)。; 以葡萄柚皮为原料,采用水热法制备碳量子点(G-CQDs),并以此构建一种用于金银花中Pb^(2+)检测的荧光生物传感器。利用圆二色光谱、透射电子显微镜、紫外-可见吸收光谱、荧光光谱等对G-CODs的形貌和光学性能进行表征,优化该荧光生物传感...; 关键词：荧光生物传感器碳量子点 DNAZYME G-四链体金银花 Pb^(2+)

基于DNAzyme的自锁免洗乳腺癌来源小细胞外囊泡超敏定量检测研究: 《中华检验医学杂志》2025年第3期396-401,共6页陈晓辉刘海霞马宁宇吴倩倩陈恒屹陈艺涂伟曹静晗罗阳; 国家自然科学基金(82241059,82125022);重庆市医学科研项目(2024QNXM028)。; 目的构建一种基于DNAzyme自锁式探针的荧光信号放大技术,用于乳腺癌来源小细胞外囊泡(sEV)的免洗超敏检测。方法设计DNAzyme自锁探针,当样本中存在乳腺癌来源sEV时,脱氧核酶DNAzyme-锁链识别其特有的上皮黏附分子EpCAM,打开DNAzyme-锁...; 关键词：细胞外囊泡液体活检脱氧核酶肿瘤检测

ZIF-90-loaded DNAzyme-responsive PROTAC for the self-powered degradation of NF-κB: 《Science China Chemistry》2025年第2期687-693,共7页Min Hou Liang Sun Tianyu Ren Mingda Li Chao Hu Rong Liu Shuang Gu Mingyan Jiang Jian-Hui Jiang Jianjun He; supported by the National Natural Science Foundation of China(NSFC)Programs(22204046);the Hunan Science Fund for Excellent Young Scholars(2023JJ20002);the National Key Research Program(2019YFA0905800);the Changsha Municipal Natural Science Foundation(kq2402088);the Scientific Research Fund of Hunan Provincial Education Department(22B0874,23B0844).; Transcription factors(TFs)play vital roles in regulating gene expressions.Dysregulated or mutated TFs are implicated in a wide array of diseases,highlighting their potential as drug targets.However,TFs are considered ...; 关键词：inducible proteolysis DNAZYME transcription factor ZIF-90 NF-ΚB

A colorimetric nanobiosensor with enhanced sensitivity for detection of lead(Ⅱ)in real-water samples via an adeninecytosine mismatched DNAzyme: 《Frontiers of Environmental Science & Engineering》2024年第12期167-177,共11页Jinchuan Liu Hang Yang Huanxing Li Jiancheng Wang Xiaohong Zhou; supported by the Basic Research Project of Shanxi Province,China(202203021222086);the start-up foundation of Taiyuan University of Technology,China(RY2400000583).; Facile and ultrasensitive detection of Pb^(2+)in water for remote or resource-limited environments remains challenging.DNAzyme-based colorimetric nanobiosensors have been extensively studied to regulate the assembly o...; 关键词：Trace lead(Ⅱ)ions Modified mismatched DNAzyme Gold nanoparticles Colorimetric nanobiosensor Environmental water samples

Unraveling the interplay of DNAzyme and interfacial factors for enhanced biosensing: 《Chinese Chemical Letters》2024年第12期249-253,共5页Yiyang Shen Zhen Zhang Ruyi Liang Tongbo Wu; financially supported by the National Natural Science Foundation of China(Nos.82172372 and 82302651);the Training Program of Innovation and Entrepreneurship for Undergraduates of Hubei Province(No.S202210487267)。; Deoxyribozyme(DNAzyme)and its substrate hybridization are crucial for achieving desirable detection performance in the DNAzyme coupling nanomaterial biosensor system.However,interfacial factors such as electrostatic r...; 关键词：DNAZYME Gold nanoparticles Interfacial factor Multiple modulation functions miRNA detection

基于立足点介导的熵驱动双足DNA步行器及树枝状杂交链式反应的一步式循环肿瘤DNA微流控传感研究: 《分析化学》2024年第11期1755-1765,共11页杨梅傅裕张何马文杰豆玉豪傅昕李满霞曾超然; 国家自然科学基金项目(No.21005067);湖南省重点研发计划项目(No.2020SK3019);湖南省研究生科研创新项目(No.CX20221292);湖南省教育厅科研项目(No.23A0529)资助。; 血液中低丰度的循环肿瘤DNA(ctDNA)是一类关键癌症标志物,实现ctDNA的精准检测对于疾病的早期诊断、监测及预后评估均具有重要意义。本研究设计了一种基于微流控芯片的熵驱动双足DNA步行器与树枝状杂交链式反应相结合的级联信号放大策略...; 关键词：DNA步行器熵驱动链置换反应微流控芯片 8-17 DNAzyme 树枝状杂交链式反应

基于DNAzyme的荧光生物传感器快速检测金黄色葡萄球菌研究: 《华南农业大学学报》2024年第5期764-771,共8页木卡地斯·米吉提王辉潘东霞申瑶杨亮; 广东省重点研发计划(2023B0202140001-3);新一代人工智能国家科技重大专项(2021ZD0113801);山东省重点研发计划(2022TZXD0016-1)。; 【目的】为解决传统方法检测金黄色葡萄球菌耗时长、操作复杂等问题,研发一种基于脱氧核酶(DNAzyme)的荧光生物传感器,实现金黄色葡萄球菌的快速检测。【方法】将特异性DNAzyme和互补链Subatrate相结合制成荧光生物传感器,并对荧光生物...; 关键词：金黄色葡萄球菌 DNAZYME 分子信标荧光生物传感器

Allosteric DNAzyme-based encoder for molecular information transfer: 《Chinese Chemical Letters》2024年第7期235-241,共7页Minghao Hu Tianci Xie Yuqiang Hu Longjie Li Ting Wang Tongbo Wu; financially supported by the National Natural Science Foundation of China(No.82172372);the Opening Research Fund of State Key Laboratory of Digital Medical Engineering(No.2023-M04)。; Dynamic DNA nanotechnology plays a significant role in nanomedicine and information science due to its high programmability based on Watson-Crick base pairing and nanoscale dimensions.Intelligent DNA machines and netw...; 关键词：DNAZYME ENCODER Nucleic acids DNA circuit DNA strand displacement Dynamic DNA nanotechnology

Engineering self-catabolic DNAzyme nanospheres for synergistic anticancer therapy: 《Science China Chemistry》2024年第7期2412-2422,共11页Yu Chen Yu Guo Jiaoli Wang Ruiting Liu Xiaohai Yang Kemin Wang Ying Pu Hui Shi Jin Huang; supported by the National Natural Science Foundation of China(22174042 and 22374038);the Natural Science Foundation for Distinguished Young Scholars of Hunan Province(2021JJ10011);the Postgraduate Scientific Research Innovation Project of Hunan Province(CX20220390)。; DNAzyme-based gene therapy faces some challenges including cell penetration,activity limitation,and co-delivery functions.Self-assembled DNA nanomedicine has attracted widespread attention due to its many advantages.I...; 关键词：DNAzyme nanosphere ZnO NPs ROS DOX anticancer therapy

基于DNAzyme辅助信号放大的荧光检测APE1: 《青岛科技大学学报（自然科学版）》2024年第3期31-36,共6页葛永浩宋盼张晓茹宋维玲; 国家自然科学基金项目(21705086)。; 利用脱氧核酶(DNAzyme)辅助放大荧光信号,发展了一种简便快速无嘌呤/无嘧啶内切酶(APE1)的高灵敏度检测策略。验证了实验可行性,对反应时间、反应温度进行了优化,在最优条件下对目标物APE1进行了检测,检测限为3.0×10^(-4)U·mL^(-1),...; 关键词：DNAZYME 荧光 APE1 信号放大

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