OXPHOS

作品数：20被引量：17H指数：2
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相关领域：医药卫生更多>>
相关作者：张帆葛红山周建伟黄检英刘倩倩更多>>
相关机构：吉林大学温州医科大学中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所)南方医科大学更多>>
相关期刊：《现代生物医学进展》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《中药药理与临床》更多>>
相关基金：国家自然科学基金天津市自然科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Immunometabolic rewiring in macrophages for periodontitis treatment via nanoquercetin-mediated leverage of glycolysis and OXPHOS
《Acta Pharmaceutica Sinica B》2024年第11期5026-5036,共11页Yi Zhang Junyu Shi Jie Zhu Xinxin Ding Jianxu Wei Xue Jiang Yijie Yang Xiaomeng Zhang Yongzhuo Huang Hongchang Lai 
National Key Research and Development Program of China(2022YFE0203600,China);National Nature Science Foundation of China(82271028,82341232);Department of Science and Technology of Guangdong Province(High-level New R&D Institute 2019B090904008,High-level Innovative Research Institute 2021B0909050003,China);Zhongshan Municipal Bureau of Science and Technology(LJ2021001&CXTD2022011,China);It also supported by the Project of Biobank(YBKB202102,China);Research Discipline Fund(KQYJXK2020,China);Cross-disciplinary Research Fund(JYJC202205,China)from Shanghai Ninth People's Hospital(SHSMU-ZDCX20212500,China);Shanghai Pujiang Program(22PJD038,China).
Periodontitis is a chronic inflammatory disease marked by a dysregulated immune microenvironment, posing formidable challenges for effective treatment. The disease is characterized by an altered glucose metabolism in ...
关键词：QUERCETIN PERIODONTITIS Macrophage GLYCOLYSIS Oxidative phosphorylation(OXPHOS) Mesoporous polydopamine Mitochondrial reactive oxygen species 
Exogenous Beta-guanidinopropionic acid administration enhances electromyostimulation-induced mitochondrial biogenesis in rat skeletal muscle
《Translational Exercise Biomedicine》2024年第3期295-304,共10页Naoki Fukao Junya Takegaki Ryo Takagi Koki Okumura Satoshi Fujita 
supported by JSPS KAKENHI Grant Number JP21KK0177 to SF.
Objectives Exercise training induces several skeletal muscle adaptations.Beta-guanidinopropionic acid(β-GPA)is a creatine analog that simulates the effect of exercise to induce mitochondrial biogenesis.However,the ef...
关键词：PGC-1Α AMPK OXPHOS CALCINEURIN muscle proteolysis 
中药干预乳腺癌氧化磷酸化的研究进展
《中药药理与临床》2024年第5期115-122,共8页唐苏媛 孙有智 刘振豪 赵益 
国家自然科学基金项目(编号:82060868);江西省自然科学基金项目(编号:20202BABL206127);江西省教育厅科技项目(编号:GJJ2200907);江西省中医药骨干人才培养项目(赣中医药科教字[2021]4号);江西中医药大学校级科技创新团队发展计划(编号:CXTD22007);熊墨年国医名师传承工作室建设项目(赣中医药综合字[2021]12号)。
氧化磷酸化(OXPHOS)对肿瘤细胞的能量代谢起着重要的调节作用,近年来中药对其干预作用的研究越来越多。为更好地梳理中药对肿瘤细胞氧化磷酸化的影响,本文就近年来中药对乳腺癌氧化磷酸化代谢方式的干预研究进行综述。发现有19个中药成...
关键词：乳腺癌 氧化磷酸化 OXPHOS 中药 
Mitochondrial genome variability and metabolic alterations reveal new biomarkers of resistance in testicular germ cell tumors
《Cancer Drug Resistance》2024年第1期24-43,共20页Pavlina Kabelikova Danica Ivovic Zuzana Sumbalova Miloslav Karhanek Lucia Tatayova Martina Skopkova Michal Cagalinec Vladimira Bruderova Jan Roska Dana Jurkovicova 
supported by the VEGA Grant Agency of the Slovak Republic(grant no.2/0056/21);the Slovak Research and Development Agency(grant no.APVV-19-0286);Doctoral grant of the Slovak Academy of Sciences(grant no.APP0377).
Aim:Mutations in the mitochondrial(mt)genome contribute to metabolic dysfunction and their accumulation relates to disease progression and resistance development in cancer cells.This study explores the mutational stat...
关键词：Testicular cancer CHEMORESISTANCE MITOCHONDRIA mtDNA mutation OXPHOS GLYCOLYSIS 
Lactylation constrains OXPHOS under hypoxia被引量：1
《Cell Research》2024年第2期91-92,共2页Haowen Ren Di Zhang 
Cells sense and adapt to oxygen availability.A new study published in Cell Research reports that hypoxia-induced mitochondrial protein lactylation halts oxidative phosphorylation,underscoring the swift cellular respon...
关键词：HYPOXIA OXIDATIVE DAMAGE 
Exposure to Electromagnetic Fields from Mobile Phones and Fructose consumption Coalesce to Perturb Metabolic Regulators AMPK/SIRT1-UCP2/FOXO1 in Growing Rats被引量：1
《Biomedical and Environmental Sciences》2023年第11期1045-1058,共14页Ruchi Tripathi Sanjay Kumar Banerjee Jay Prakash Nirala Rajani Mathur 
supported by the Indian Council of Medical Research(ICMR)in New Delhi.(Sanction NO:5/10/FR/13/2015-RBMH)。
Objective In this study,the combined effect of two stressors,namely,electromagnetic fields(EMFs)from mobile phones and fructose consumption,on hypothalamic and hepatic master metabolic regulators of the AMPK/SIRT1-UCP...
关键词：EMF-mobile phone FRUCTOSE Childhood-adolescence Insulin receptor signal Mitochondrial OxPHOS Antioxidant system Hypothalamic insulin resistance Hepatic insulin resistance 
Targeting metabolic vulnerabilities to overcome resistance to therapy in acute myeloid leukemia被引量：1
《Cancer Drug Resistance》2023年第3期567-589,共23页Priyanka Sharma Gautam Borthakur 
Malignant hematopoietic cells gain metabolic plasticity, reorganize anabolic mechanisms to improve anabolic output and prevent oxidative damage, and bypass cell cycle checkpoints, eventually outcompeting normal hemato...
关键词：OXPHOS DHODH leukemia stem cells mesenchymal stromal cells IDH 
BaTiO_(3)@Au nanoheterostructure suppresses triple-negative breast cancer by persistently disrupting mitochondrial energy metabolism
《Nano Research》2023年第2期2775-2785,共11页Yanlin Feng Jianlin Wang Xin Ning Aiyun Li Qing You Wanzhen Su Deping Wang Jianyun Shi Lan Zhou Fangfang Cao Xiaoyuan Chen Jimin Cao 
supported by the National Natural Science Foundation of China(Nos.22007063 and 82002063);Shanxi Medical Key Science and Technology Project Plan of China(No.2020XM01);the National University of Singapore Start-up Grant(No.NUHSRO/2020/133/Startup/08);NUS School of Medicine Nanomedicine Translational Research Program(No.NUHSRO/2021/034/TRP/09/Nanomedicine);the Science Research Start-up Fund for Doctor of Shanxi Province(No.XD1809 and XD2011);the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2019L0414);Shanxi Province Science Foundation for Youths(No.201901D211316).
Abnormal metabolism has become a potential target for highly malignant and invasive triple-negative breast cancer(TNBC)due to its relatively low response to traditional therapeutics.The existing metabolic intervention...
关键词：pyroelectric nanoheterostructure reactive oxidative species(ROS) metabolic interventions mitochondrial oxidative phosphorylation(OXPHOS) triple-negative breast cancer(TNBC) 
Berberine targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia with IDH1 mutation
《Chinese Journal of Natural Medicines》2023年第2期136-145,共10页HUANG Zhe SHEN Yunfu LIU Wenjun YANG Yan GUO Ling YAN Qin WEI Chengming GUO Qulian FAN Xianming MA Wenzhe 
supported by Sichuan Science and Technology Program(No.2022YFS0622);the Science and Technology Development Fund,Macao SAR(Nos.0036/2020/A1 and 0013/2019/A1).
Metabolic reprogramming,a newly recognized trait of tumor biology,is an intensively studied prospect for oncology medicines.For numerous tumors and cancer cell subpopulations,oxidative phosphorylation(OXPHOS)is essent...
关键词：BERBERINE Oxidative phosphorylation Complex I Mutant IDH1 Acute myeloid leukemia 
Metabolism along the life journey of T cells被引量：1
《Life Metabolism》2023年第1期24-32,共9页Min Peng Ming O.Li 
M.P.is supported by National Natural Science Foundation of China(31741085);Tsinghua University Initiative Scientific Research Program(2021Z);Vanke Special Fund for Public Health and Health Discipline Development,Tsinghua University(2022Z82WKJ013);Tsinghua-Peking Center for Life Sciences and Institute for Immunology at Tsinghua University.M.O.L.is supported by NIH(R01 AI 102888);a Howard Hughes Medical Institute Faculty Scholar Award and by Memorial Sloan Kettering Cancer Center Support Grant(Core Grant P30 CA08748).
T cells are one of few cell types in adult mammals that can proliferate extensively and differentiate diversely upon stimulation,which serves as an excellent example to dissect the metabolic basis of cell fate decisio...
关键词：T cells immunometabolism GLYCOLYSIS OXPHOS FAO ACETYL-COA 
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