Metabolism along the life journey of T cells  

作　　者：Min Peng Ming O.Li 

机构地区：[1]Department of Basic Medical Sciences,School of Medicine,Tsinghua University,Beijing 100084,China [2]Institute for Immunology,Tsinghua University,Beijing 100084,China [3]Tsinghua-Peking Center for Life Sciences,Beijing 100084,China [4]Beijing Key Laboratory for Immunological Research on Chronic Diseases,Tsinghua University,Beijing 100084,China [5]Immunology Program,Sloan Kettering Institute,Memorial Sloan Kettering Cancer Center,New York,NY 10065,USA [6]Immunology and Microbial Pathogenesis Program,Weill Cornell Graduate School of Medical Sciences,Cornell University,New York,NY 10065,USA

出　　处：《Life Metabolism》2023年第1期24-32,共9页生命（代谢（英文）

基　　金：M.P.is supported by National Natural Science Foundation of China(31741085);Tsinghua University Initiative Scientific Research Program(2021Z);Vanke Special Fund for Public Health and Health Discipline Development,Tsinghua University(2022Z82WKJ013);Tsinghua-Peking Center for Life Sciences and Institute for Immunology at Tsinghua University.M.O.L.is supported by NIH(R01 AI 102888);a Howard Hughes Medical Institute Faculty Scholar Award and by Memorial Sloan Kettering Cancer Center Support Grant(Core Grant P30 CA08748).

摘　　要：T cells are one of few cell types in adult mammals that can proliferate extensively and differentiate diversely upon stimulation,which serves as an excellent example to dissect the metabolic basis of cell fate decisions.During the last decade,there has been an explosion of research into the metabolic control of T-cell responses.The roles of common metabolic pathways,including glycolysis,lipid metabolism,and mitochondrial oxidative phosphorylation,in T-cell responses have been well characterized,and their mechanisms of action are starting to emerge.In this review,we present several considerations for T-cell metabolism-focused research,while providing an overview of the metabolic control of T-cell fate decisions during their life journey.We try to synthesize principles that explain the causal relationship between cellular metabolism and T-cell fate decision.We also discuss key unresolved questions and challenges in targeting T-cell metabolism to treat disease.

关 键 词：T cells immunometabolism GLYCOLYSIS OXPHOS FAO ACETYL-COA 

分 类 号：Q251[生物学—细胞生物学]