ACETYL-COA

作品数：18被引量：28H指数：4
导出分析报告
相关领域：医药卫生更多>>
相关作者：梁婉婷刘丽波李春杨丹更多>>
相关机构：东北农业大学重庆医科大学苏州大学江南大学更多>>
相关期刊：《Bone Research》《Science China Earth Sciences》《Oil Crop Science》《Chinese Journal of Natural Medicines》更多>>
相关基金：国家自然科学基金上海市教育委员会重点学科基金北京市自然科学基金国家教育部博士点基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Screening of ent-copalyl diphosphate synthase and metabolic engineering to achieve de novo biosynthesis of ent-copalol in Saccharomyces cerevisiae
《Synthetic and Systems Biotechnology》2024年第4期784-792,共9页Shan Li Shuangshuang Luo Xinran Yin Xingying Zhao Xuyang Wang Song Gao Sha Xu Jian Lu Jingwen Zhou 
supported by the National Natural Science Foundation of China(22278188);the National Natural Science Foundation of China(22208123);the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(Grant No.SN-ZJU-SIAS-0013);the National First-class Discipline Program of Light Industry Technology and Engineering(QGJC20230102).
The diterpene ent-copalol is an important precursor to the synthesis of andrographolide and is found only in green chiretta(Andrographis paniculata).De novo biosynthesis of ent-copalol has not been reported,because th...
关键词：Andrographis paniculata Ent-copalyl diphosphate synthase ent-CPP Diterpene synthase ACETYL-COA Quantification 
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
《Bone Research》2024年第3期720-733,共14页Daizhao Deng Xianming Liu Wenlan Huang Sirui Yuan Genming Liu Shanshan Ai Yijie Fu Haokun Xu Xinyi Zhang Shihai Li Song Xu Xiaochun Bai Yue Zhang 
supported by Grant Nos.31872799,82070906 and 31701033 from the National Natural Science Foundation of China;Grant Nos.2020A1515011189 from Guangdong Basic and Applied Basic Research Foundation of China。
Osteoclast is critical in skeletal development and fracture healing,yet the impact and underlying mechanisms of their metabolic state on these processes remain unclear.Here,by using osteoclast-specific small GTPase Rh...
关键词：HEALING SKELETAL CATHEPSIN 
ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells被引量：1
《Acta Pharmaceutica Sinica B》2023年第12期4733-4747,共15页Mingjin Wang Weida Wang Shen You Zhenyan Hou Ming Ji Nina Xue Tingting Du Xiaoguang Chen Jing Jin 
supported by National Key R&D Program of China(No.2019YFE0111800);National Natural Science Foundation of China(Nos.T2192972,81872923,and 81903904);the CAMS Innovation Fund(2022-I2M-1-014,China).
Glioblastoma(GBM)is a highly aggressive and lethal brain tumor with an immunosuppressive tumor microenvironment(TME).In this environment,myeloid cells,such as myeloid-derived suppressor cells(MDSCs),play a pivotal rol...
关键词：GLIOBLASTOMA Myeloid cells Myeloid-derived suppressor cells Acetyl-CoA acetyltransferase 1 CXCL1 Tumor microenvironment Lipid metabolism MACROPHAGES 
Negative correlation between acetyl-CoA acyltransferase 2 and cetuximab resistance in colorectal cancer被引量：1
《Acta Biochimica et Biophysica Sinica》2023年第9期1467-1478,共12页Yitao Yuan Xun Sun Mengling Liu Suyao Li Yu Dong Keshu Hu Jiayu Zhang Bei Xu Sining Ma Hesheng Jiang Pengcong Hou Yufu Lin Lu Gan Tianshu Liu 
supported by the grants from the National Natural Science Foundation of China(Nos.81802370 and 8217111492);the Special Clinical Research Program of Shanghai Municipal Health Commission Health Industry(No.202040222);the Xiamen Natural Science Foundation Project(No.3502Z20227111);the Shanghai Natural Science Foundation(No.23ZR1421300).
The emergence of anti-EGFR therapy has revolutionized the treatment of colorectal cancer(CRC).However,not all patients respond consistently well.Therefore,it is imperative to conduct further research to identify the m...
关键词：colorectal cancer cetuximab resistance ACAA2 Kras mutation 
Gaining access to acetyl-CoA by peroxisomal surface display
《Synthetic and Systems Biotechnology》2023年第2期224-226,共3页Thomas Perrot Sebastien Besseau Nicolas Papon Vincent Courdavault 
funding from the EU Horizon 2020 research and innovation program(MIAMi project-Grant agreement N°814645);ARD-CVL Biopharmaceutical program of the Region Centre Val de Loire(ETOPOCentre project),Le Studium Institute(Consortium Fellowship)and ANR(project MIACYC-ANR-20-CE43-0010).
Synthetic biology is constantly making progress for producing compounds on demand.Recently,Yocum and collaborators have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisom...
关键词：Synthetic biology Enzymes colocalization Peroxisomal membrane ACETYL-COA POLYKETIDES 
Determination of carbon-fixing potential of Bathyarchaeota in marine sediment by DNA stable isotope probing analysis
《Science China Earth Sciences》2023年第4期910-917,共8页Wenyue LIANG Tiantian YU Liang DONG Zhongjun JIA Fengping WANG 
supported by the State Key R&D Project of China(Grant No.2016YFA0601102);the National Natural Science Foundation of China(Grant Nos.91751205,41525011&41867057)。
Bathyarchaeota is believed to play a crucial role in the global carbon cycle due to its vast biomass,broad distribution,and diverse habitat.However,its physiological and metabolic features are hard to determine withou...
关键词：Bathyarchaeota Reductive acetyl-CoA pathway Carbon fixation DNA-SIP 
Metabolism along the life journey of T cells被引量：1
《Life Metabolism》2023年第1期24-32,共9页Min Peng Ming O.Li 
M.P.is supported by National Natural Science Foundation of China(31741085);Tsinghua University Initiative Scientific Research Program(2021Z);Vanke Special Fund for Public Health and Health Discipline Development,Tsinghua University(2022Z82WKJ013);Tsinghua-Peking Center for Life Sciences and Institute for Immunology at Tsinghua University.M.O.L.is supported by NIH(R01 AI 102888);a Howard Hughes Medical Institute Faculty Scholar Award and by Memorial Sloan Kettering Cancer Center Support Grant(Core Grant P30 CA08748).
T cells are one of few cell types in adult mammals that can proliferate extensively and differentiate diversely upon stimulation,which serves as an excellent example to dissect the metabolic basis of cell fate decisio...
关键词：T cells immunometabolism GLYCOLYSIS OXPHOS FAO ACETYL-COA 
Discovery of Novel Long-Chain Alkenyl Diacid Derivatives as ACLY Inhibitors
《Chinese Journal of Chemistry》2022年第22期2663-2670,共8页Gao-Lei Song Lei Cao Mei Zhang Yu-Rou Yang Jie Ma Zhi-Fu Xie Jing-Ya Li Fa-Jun Nan 
supported by grants fromthe"Personalized Medicines-Molecular Signature-based Drug Discovery and Development"Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040328);the Medical Guidance Project of Shanghai ScienceandTechnology Commission(20S11903400);the Natural Science Foundation of Shanghai's 2021"Science and Technology InnovationAction Plan"(21ZR1475300);the National Natural Science Foundation of China(No.82170872).
ATP citrate lyase(ACLY)synthesizes cytosolic acetyl coenzyme A(acetyl-CoA),an essential biosynthetic precursor for lipid synthesis and the acetyl donor required for protein acetylation.The aberrant expression and acti...
关键词：Alkenyl diacid derivatives Cancer ACLY inhibitors ACETYL-COA Structure-activity relationships 
Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin Ⅲ to baccatin Ⅲ被引量：2
《Acta Pharmaceutica Sinica B》2021年第10期3322-3334,共13页Hao Wang Bo-Yong Zhang Ting Gong Tian-Jiao Chen Jing-Jing Chen Jin-Ling Yang Ping Zhu 
supported by the National Key Research and Development Program of China(grant Nos.2018YFA0901900 and 2020YFA0908003);the Drug Innovation Major Project(grant No.2018ZX09711001-006-001,China);the National Natural Science Foundation of China(grant No.81573325);the CAMS Innovation Fund for Medical Sciences(CIFMS,(grant No.2017-I2M-2-004,2019-I2M-1-005,China);PUMC Disciplinary Development of Synthetic Biology(201920100801,China)。
10-DeacetylbaccatinⅢ(10-DAB)C10 acetylation is an indispensable procedure for Taxol semi-synthesis,which often requires harsh conditions.10-DeacetylbaccatinⅢ-10-β-O-acetyltransferase(DBAT)catalyzes the acetylation ...
关键词：Microbial cell factory Biosynthetic pathway of acetyl-CoA Bioconversion of 10-deacetylbaccatinⅢto baccatinⅢ 10-DeacetylbaccatinⅢ-10-β-Oacetyltransferase Deacetylation of baccatinⅢ High-cell-density fermentation Taxol semi-synthesis 
Unlocking a new target for streptomycetes strain improvement
《Synthetic and Systems Biotechnology》2020年第1期33-34,共2页Yuan Chen Jackie Metz RenéK.Miller-Xavier Guojun Wang 
This article was supported in part by the Faculty Excellence support from the Harbor Branch Oceanographic Foundation.
Bacteria of the Streptomyces genus are well-known producers of secondary metabolites of high medical value.They contributed nearly 60%of current antibiotics(i.e.,vancomycin,daptomycin and tetracycline),as well as anti...
关键词：POLYKETIDE STREPTOMYCES Strain Improvement TRIACYLGLYCEROL β-oxidation ACETYL-COA 
全选清除导出
共2页<12>
检索报告 对象比较 聚类工具 使用帮助 返回顶部