POLYKETIDES

作品数：33被引量：47H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：刘发旺周梦洁杨小燕许青霞金晶更多>>
相关机构：北京大学西湖大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《Organic Chemistry Frontiers》《Chinese Journal of Natural Medicines》《Journal of Bio-X Research》更多>>
相关基金：国家自然科学基金广西壮族自治区自然科学基金国家重点基础研究发展计划王宽诚敎育基金更多>>
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Eutypetides A—E,Structurally Intriguing Polyketides Formed by Intramolecular[4+2]Cycloaddition from Marine-Derived Fungus Eutypella sp.F0219
《Chinese Journal of Chemistry》2025年第1期23-32,共10页Zhong-Ping Jiang Meng-Ting Chen Xiao Xiang Cong-Jun Xu Yong Rao Hong-Zhi Du Wan-Shan Li Ling Huang 
supported by the National Natural Science Foundation of China(82204275,82160653,and 22267006);Natural Science Foundation of Hainan Province(323Ms014 and 222QN303);Fundamental Research Funds for Hainan University(KYQD(ZR)-22088 and KYQD(ZR)-21089)。
Four polycyclic ten-membered lactones possessing unprecedented 10/6/5 tricyclic ring skeleton,named eutypetides A—D(1—4),and an intriguing polyketide containing a hexahydroisobenzofuran-1(3H)-one motif,named eutypet...
关键词：Marine-derived fungus Eutypella sp.F0219 POLYKETIDES Polycyclic macrolides [4+2]cycloaddition 
Talaketides A-G,linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp.SCSIO 41027
《Chinese Journal of Natural Medicines》2024年第11期1047-1056,共10页CHEN Chunmei WANG Xueni FANG Wenxuan LIANG Jiaqi CAI Jian YANG Dehua LUO Xiaowei GAO Chenghai YI Xiangxi LIU Yonghong ZHOU Xuefeng 
supported by the Key-Area Research and Development Program of Guangdong Province(No.2023B1111050008);the National Natural Science Foundation of China(Nos.U23A20528,U20A20101);Guangdong Local Innovation Team Program(No.2019BT02Y262);the Postdoctoral Fellowship Program of CPSF(No.GZC20232777).
Seven novel linear polyketides,talaketides A-G(1-7),were isolated from the rice media cultures of the mangrove sed-iment-derived fungus Talaromyces sp.SCSIO 41027.Among these,talaketides A-E(1-5)represented unpreceden...
关键词：Mangrove sediment-derived fungus Talaromyces sp.Linear polyketides Cytotoxicity Prostate cancer 
Multioxidized polyketides from an endophytic Penicillium sp.YUD17006 associated with Gastrodia elata
《Chinese Journal of Natural Medicines》2024年第11期1057-1064,共8页LI Hongtao YANG Ruining XIE Fei XIE Tianpeng TANG Linhuan ZHOU Hao DING Zhongtao 
supported by the Natural Science Foundation of China(No.22267001);the Program for Innovative Research Team of Yunnan Province(No.202105AE160006);the Science and Technology Project of Yunnan Province(Nos.202201AT070225,202301AU070217);Yunnan University“Double First-Class”Construction Joint Project(No.202201BF070001-014);Basic Research Plan of Yunnan Provincial Science and Technology Department-Kunming Medical University(No.202301AY070001-186);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(No.2022YKZY001);Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission&Ministry of Education,Yunnan Minzu University(No.MZY2205);he Program Innovative Research Team in Science and Technology in Kunming Medical University(No.CXTD202202)。
Three novel,highly oxygenated polyketides,multioketides A-C(1-3),and three previously described multioxidized aromatic polyketides(4-6),were isolated from an endophytic Penicillium sp.YUD17006 associated with Gastrodi...
关键词：Penicillium sp.Multioxidized polyketides Secondary metabolite Anti-acetylcholinesterase activity PTP1B inhibit-ory activity 
Editing function of type Ⅱ thioesterases in the biosynthesis of fungal polyketides
《Chinese Chemical Letters》2024年第10期325-328,共4页Fenglin Jiang Anan Liu Qian Wei Youcai Hu 
supported financially by the National Natural Science Foundation of China(Nos.82225042,T2192973);the CAMS Innovation Fund for Medical Sciences(No.CIFMS 2021-I2M1-029)。
Polyketide synthases(PKSs)are megasynthases with multiple autonomously folding domains,which operate cooperatively in the PKS assemblies to synthesize specific polyketide scaffolds.Any nonreactive intermediates tether...
关键词：Editing enzyme Type II thioesterase BIOSYNTHESIS Polyketide synthase Metabolic engineering 
Asperochones A and B,two antimicrobial aromatic polyketides from the endophytic fungus Aspergillus sp.MMC-2
《Chinese Chemical Letters》2024年第9期206-209,共4页Hong Zhang Cui-Ping Li Li-Li Wang Zhuo-Da Zhou Wen-Sen Li Ling-Yi Kong Ming-Hua Yang 
supported by the National Natural Science Foundation of China(No.32170403);the 111 Center from Ministry of Education of China and the State Administration of Foreign Experts Affairs of China(No.B18056);the“Double First-Class”University Project(No.CPU2018GF03);the Drug Innovation Major Project(Nos.2018ZX09711-001-007 and 2018ZX09735002-003)。
Two novel fungal metabolites,asperochones A and B,were obtained from an Aspergillus sp.Their structures were determined by 1D/2D nuclear magnetic resonance(NMR)spectroscopy,high resolution electrospray ionization mass...
关键词：Aspergillus sp. Asperochones A and B Aromatic polyketides Heterotrimeric compound Anti-tuberculosis effect Antifibrotic activity 
Total Syntheses of Favolasins A,E,G and K,Polyketides Isolated from Cultures of the Basidiomycetes Fungi Favolaschia sp.BCC 18686 and Favolaschia calocera BCC 36684
《Chinese Journal of Chemistry》2023年第12期1450-1464,共15页Bingbing Sheng Ping Lan Jolynn Kiong Zeinab G. Khalil Robert J. Capon Martin G.Banwell 
National Natural Science Foundation of China(Grant Nos.22250410258 and 22250410259);the Ministry of Science and Technology of the People's Republic of China for financial support.
The structures assigned to all four members,1-4,of the recently reported favolasin class of natural product have been prepared for the first time by chemical synthesis.Suzuki-Miyaura cross-coupling chemistry was used ...
关键词：Total syntheses Favolasins Suzuki-Miyaura cross-coupling ACETALIZATION ANTI-MALARIAL 
Protein engineering for natural product biosynthesis:expanding diversity for therapeutic applications
《Journal of Bio-X Research》2023年第2期49-60,共12页Sarah Oluwatobi Otun Jordy Alexis Lerma-Escalera Khayalethu Ntushelo Ikechukwu Achilonu 
funded by the University of Witwatersrand postdoctoral research fellowship obtained by O.S;supported by the South African Research Chairs Initiative(SARChI)of the Department of Science and Technology;the National Research Foundation(grant 64788 to I.A.).
In this dispensation of the fourth industrial revolution,protein engineering has become a popular approach for increasing enzymatic activity,stability,and titer in the biosynthesis of natural products.This is attribut...
关键词：antibodies engineering industrial enzymes natural product biosynthesis protein engineering POLYKETIDES synthetic biology 
Gaining access to acetyl-CoA by peroxisomal surface display
《Synthetic and Systems Biotechnology》2023年第2期224-226,共3页Thomas Perrot Sebastien Besseau Nicolas Papon Vincent Courdavault 
funding from the EU Horizon 2020 research and innovation program(MIAMi project-Grant agreement N°814645);ARD-CVL Biopharmaceutical program of the Region Centre Val de Loire(ETOPOCentre project),Le Studium Institute(Consortium Fellowship)and ANR(project MIACYC-ANR-20-CE43-0010).
Synthetic biology is constantly making progress for producing compounds on demand.Recently,Yocum and collaborators have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisom...
关键词：Synthetic biology Enzymes colocalization Peroxisomal membrane ACETYL-COA POLYKETIDES 
An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509被引量：1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第3期275-280,共6页Miaoping LIN Zhenzhou TANG Jiaxi WANG Humu LU Chenwei WANG Yanting ZHANG Xinming LIU Chenghai GAO Yonghong LIU Xiaowei LUO 
supported by the Guangxi Natural Science Foundation(Nos.2020GXNSFBA159001,2020GXNSF GA297002,and 2021GXNSFAA220052);the National Natural Science Foundation of China(Nos.U20A20101 and 22007019);the Special Fund for Bagui Scholars of Guangxi(Yonghong LIU);the Scientific Research Foundation of Guangxi University of Chinese Medicine(No.2022C038),China.
Marine microorganisms,especially marine fungi,have historically proven their value as a prolific source for structurally novel and pharmacologically active secondary metabolites(Deshmukh et al.,2018;Carroll et al.,202...
关键词：habitat ALKALOID skeleton 
Global-scale analysis reveals distinct patterns of non-ribosomal peptide and polyketide synthase encoding genes in root and soil bacterial communities
《Soil Ecology Letters》2023年第1期38-45,共8页Barak Dror Edouard Jurkevitch Eddie Cytryn 
Secondary metabolites(SMs)produced by soil bacteria,for instance antimicrobials and siderophores,play a vital role in bacterial adaptation to soil and root ecosystems and can contribute to plant health.Many SMs are no...
关键词：Secondary metabolites Plant-microbe interactions Non-ribosomal peptides POLYKETIDES Rhizosphere microbiome Soil microbiome 
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