An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509  

作　　者：Miaoping LIN Zhenzhou TANG Jiaxi WANG Humu LU Chenwei WANG Yanting ZHANG Xinming LIU Chenghai GAO Yonghong LIU Xiaowei LUO 

机构地区：[1]Institute of Marine Drugs,Guangxi Key Laboratory of Marine Drugs,Guangxi University of Chinese Medicine,Nanning 530200,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第3期275-280,共6页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the Guangxi Natural Science Foundation(Nos.2020GXNSFBA159001,2020GXNSF GA297002,and 2021GXNSFAA220052);the National Natural Science Foundation of China(Nos.U20A20101 and 22007019);the Special Fund for Bagui Scholars of Guangxi(Yonghong LIU);the Scientific Research Foundation of Guangxi University of Chinese Medicine(No.2022C038),China.

摘　　要：Marine microorganisms,especially marine fungi,have historically proven their value as a prolific source for structurally novel and pharmacologically active secondary metabolites(Deshmukh et al.,2018;Carroll et al.,2022).The corals constitute a dominant part of reefs with the highest biodiversity,and harbor highly diverse and abundant microbial symbionts in their tissue,skeleton,and mucus layer,with species-specific core members that are spatially partitioned across coral microhabitats(Wang WQ et al.,2022).The coral-associated fungi were very recently found to be vital producers of structurally diverse compounds,terpenes,alkaloids,peptides,aromatics,lactones,and steroids.

关 键 词：habitat ALKALOID skeleton 

分 类 号：R284[医药卫生—中药学]