ALKALOID

作品数：296被引量：790H指数：13
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相关领域：理学医药卫生更多>>
相关作者：刘志强刘淑莹宋凤瑞叶文才冯锋更多>>
相关机构：中国科学院中国药科大学北京中医药大学北京大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金北京市自然科学基金更多>>
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Arecoline,a main alkaloid in Areca catechu,induces biological changes in human papillomavirus 16-positive cervical cancer cells via upregulation of viral oncogenes and cellular transcriptional factors
《Asian Pacific Journal of Tropical Biomedicine》2025年第3期119-128,I0016-I0018,共13页Jureeporn Chuerduangphui Chaleampol Loymunkong Tipaya Ekalaksananan Chamsai Pientong 
Objective:To investigate the effects of arecoline on HPV-positive cervical cells and unveil its underlying mechanism in cervical carcinogenesis.Methods:The cytotoxicity of arecoline was determined and the effect of su...
关键词：ARECOLINE Human papillomavirus ONCOGENES Cervical cancer c-Fos 
The biologically and ecologically important natural products from the Chinese sea hare Bursatella leachii:structures,stereochemistry and beyond
《Chinese Journal of Natural Medicines》2024年第11期1030-1039,共10页ZHANG Xinyuan SU Mingzhi ZHU Mingxin CHEN Sha GAO Zhen GUO Yuewei LI Xuwen 
supported by the National Key Research andDevelopment ProgramofChina(Nos.2021YFF0502400,2022YFC2804100);the Natural Science Foundation of China(Nos.82022069,42076099);Shandong Laboratory Program(No.SYS202205);the“Youth Innovation Promotion Association”of CAS(No.Y202065);the Fundamental Research Projects of Science&Technology In-novation and development Plan in Yantai City(No.2023JCYJ057);the CAS Youth Interdisciplinary Team,the Shandong Science and Technology Major Project of Innovation and Entrepreneurship Community with Antibodydrug(No.E321020);Youth Fund from Natural Science Foundation of Shandong Province(No.ZR2023QD162)。
A novel amide alkaloid,bursatamide A(1),featuring an unprecedented propyl-hexahydronaphthalene carbon frame-work,was isolated from the infrequently studied sea hare Bursatella leachi,alongside a new 3-phenoxypropaneni...
关键词：Bursatella leachii Marine natural product ALKALOID Sea hare Antibacterial activity 
The Clausena lansium genome provides new insights into alkaloid diversity and the evolution of the methyltransferase family
《Journal of Integrative Agriculture》2024年第10期3537-3553,共17页Yongzan Wei Yi Wang Fuchu Hu Wei Wang Changbin Wei Bingqiang Xu Liqin Liu Huayang Li Can Wang Hongna Zhang Zhenchang Liang Jianghui Xie 
supported by the Central Public-interest Scientific Institution Basal Research Fund for the Chinese Academy of Tropical Agricultural Sciences(1630062019010 and 1630062020010);the Fund of Protection of Species Resources for the Ministry of Agriculture and Rural Affairs of China(125A0605)。
Wampee(Clausena lansium)is an important evergreen fruit tree native to southern China that has a long history of use for medicinal purposes.Here,a chromosome-level genome of C.lansium was constructed with a genome siz...
关键词：Clausena lansium GENOME EVOLUTION methyltransferase activity alkaloid biosynthesis coumarin accumulation 
Antibacterial and cytotoxic metabolites produced by Streptomyces tanashiensis BYF-112 isolated from Odontotermes formosanus
《Chinese Journal of Natural Medicines》2024年第9期822-830,共9页WU Jun SONG Tao ZHANG Le HUANG Zhongdi HUANG Fang YIN Caiping ZHANG Shuxiang LIU Xinhua ZHANG Yinglao 
supported by the Natural Science Funds for Distinguished Young Scholars of Anhui Province(No. 2108085J18);the National Natural Science Foundation of China (Nos. 32011540382 and 32102272)。
Chemical investigations of the termite-associated Streptomyces tanashiensis BYF-112 resulted in the discovery of four novel alkaloid derivatives: vegfrecines A and B(1 and 2), exfoliazone A(3), and venezueline H(7), i...
关键词：Odontotermes formosanus Streptomyces tanashiensis ALKALOID Cytotoxic activity Antibacterial activity Biosynthetic pathway 
Total synthesis of a putative yuzurimine-type Daphniphyllum alkaloid C_(14)–epi-deoxycalyciphylline H
《Chinese Chemical Letters》2024年第4期336-339,共4页Jingping Hu Jing Xu 
the National Natural Science Foundation of China (Nos.21971104 and 22271136);Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis (No.ZDSYS20190902093215877);Guangdong Provincial Key Laboratory of Catalysis (No.2020B121201002);Guangdong Innovative Program (No.2019BT02Y335);Education Department of Guangdong Province, Key research projects in colleges and universities in Guangdong Province (No.2021ZDZX2035);Shenzhen Nobel Prize Scientists Laboratory Project (No.C17783101);Innovative Team of Universities in Guangdong Province (No.2020KCXTD016)。
One of the largest subfamilies within the famous Daphniphyllum alkaloid family is made up of the yuzurimine-type(or macrodaphniphyllamine-type) alkaloids. Their complex aza-polycyclic caged structures, several contigu...
关键词：Total synthesis Daphniphyllum alkaloids Yuzurimine-type alkaloids Prins reaction Enyne cycloisomerization 
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for rapid analysis of eight Gelsemium elegans Benth alkaloids in human plasma and urine
《One Health Advances》2024年第1期20-30,共11页Xi Zeng Yu Wang Lin Luo Yina Lu Zhenlin Xu 
supported by the National Natural Science Foundation of China(Grant No.32372448);Guangdong Basic and Applied Basic Research Foundation,China(Grant No.2023A1515012605);the Science and Technology Program of Guangdong Administration for Market Regulation,China(Grant No.2023CS01);the Science and Technology Program of National General Customs Administration of China(Grant No.2022HK108);the Science and Technology Program of Shantou City,China(Grant No.STKJ2023024).
Gelsemium elegans Benth alkaloids are the main components of G.elegans and can cause acute toxicosis or even death.Although several studies have reported methods for detecting G.elegans alkaloids,a high-throughput and...
关键词：Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Gelsemium elegans Benth High-throughput trial ALKALOID Acute poisoning Biological sample 
Carbonic anhydrase-like enzymes in the formation of Lycopodium alkaloid
《Chinese Journal of Natural Medicines》2024年第3期193-194,共2页DONG Huiwen GE Huiming 
Plant alkaloids,renowned for their structural diversity and bioactivity,are prominent in both modern and traditional medicine[1].Unraveling the intricacies of plant alkaloid biosynthesis could pave the way for the dis...
关键词：Lycopodium alkaloid Carbonic anhydrase-like enzymes BIOSYNTHESIS 
Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum
《Chinese Journal of Chemistry》2024年第1期35-42,共8页Qing Tang Xiao-Yong Dai Qiang Lin Zhi-Peng Ling Yi-Kun Hao Tian-Xi Zhu Ji-Hui Zhang Yi-Bo Hou Yao-Lan Li Lai-Qiang Huang Jing-Hao Wang Guo-Cai Wang Yu-Bo Zhang 
supported by grants from the National Natural Science Foundation of China(Nos.82173695,82273803,82003743,81973190);the Guangdong Basic and Applied Basic Research Foundation(No.2020B1515020033);Scienceand Technology Planning Projectof Guangzhou City(No.202201010485).
Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum calycinum.Compound 1 is the first Daphniphyllum alkaloid ...
关键词：Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma 
A Pair of New Spirocyclic Alkaloid Enantiomers with TrxR Inhibitory Activities Were Isolated from Marine-Derived Aspergillus ruber TX-M4-1被引量：1
《Journal of Ocean University of China》2023年第6期1677-1682,共6页WANG Cong WANG Yufei SUN Jian WANG Shiyi DU Weisheng ZHOU Liman KONG Fandong 
supported by the National Natural Science Foundation of China(No.82204276);the Guangxi Natural Science Foundation(No.2021GXNSFBA075036);the Specific Research Project of Guangxi for Research Bases and Talents(Nos.AD22035018,AD20297036);the 2021 University-Level Scientific Research Projects of Guangxi Minzu University(No.2021MDKJ003);the Talent Scientific Research Initiation Project of Guangxi Minzu University(No.2021KJQD09);the Xiangsi Lake Youth Innovation Team Project of Guangxi Minzu University(No.2021 RSCXSHQN01);the Guangxi Scholarship Fund of Guangxi Education Department.
One new spirocyclic alkaloid,5-isopentenyl-cryptoechinuline D(1),along with 11 known compounds(2–12),were iso-lated from a marine fungus Aspergillus ruber TX-M4-1.The structures of compounds 1–12 were elucidated by ...
关键词：Aspergillus ruber TX-M4-1 spirocyclic alkaloid TrxR inhibitory activity 
Corrigendum to“GB7 acetate,a galbulimima alkaloid from Galbulimima belgraveana,possesses anticancer effects in colorectal cancer cells”[J.Pharm.Anal.12(2022)339e349]
《Journal of Pharmaceutical Analysis》2023年第12期1580-1581,共2页Ziyin Li Lianzhi Mao Bin Yu Huahuan Liu Qiuyu Zhang Zhongbo Bian Xudong Zhang Wenzhen Liao Suxia Sun 
Original statement in Section 3.5:3.5.GB7 acetate reduced the mobility and invasion of HCT 116 cells The wound healing assay showed that GB7 acetate significantly decreased the migration area of HCT 116 cells when com...
关键词：ACETATE HEALING INVASION 
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