Asperochones A and B,two antimicrobial aromatic polyketides from the endophytic fungus Aspergillus sp.MMC-2  

作　　者：Hong Zhang Cui-Ping Li Li-Li Wang Zhuo-Da Zhou Wen-Sen Li Ling-Yi Kong Ming-Hua Yang 

机构地区：[1]Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China

出　　处：《Chinese Chemical Letters》2024年第9期206-209,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.32170403);the 111 Center from Ministry of Education of China and the State Administration of Foreign Experts Affairs of China(No.B18056);the“Double First-Class”University Project(No.CPU2018GF03);the Drug Innovation Major Project(Nos.2018ZX09711-001-007 and 2018ZX09735002-003)。

摘　　要：Two novel fungal metabolites,asperochones A and B,were obtained from an Aspergillus sp.Their structures were determined by 1D/2D nuclear magnetic resonance(NMR)spectroscopy,high resolution electrospray ionization mass spectroscopy(HRESIMS),and single-crystal X-ray diffraction analysis.Asperochone A possesses an intriguing skeleton bearing 5/6/6/6/7/5/5/5 octacyclic ring system,and asperochone B also exhibits an unusual carbon skeleton with five stereochiral centers.Their structures were proposed as heterotrimeric and heterodimeric products of aromatic polyketides.In addition,asperochone A exhibited a potential anti-tuberculosis effect since it showed a moderate potency against Mycobacterium smegmatis.

关 键 词：Aspergillus sp. Asperochones A and B Aromatic polyketides Heterotrimeric compound Anti-tuberculosis effect Antifibrotic activity 

分 类 号：R914[医药卫生—药物化学] O629[医药卫生—药学]