POLYKETIDE

作品数：31被引量：42H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：李宁张敏戴均贵王春梅邹建华更多>>
相关机构：中国科学院上海交通大学北京协和医学院药物研究所北京中医药大学更多>>
相关期刊：《Asian Pacific Journal of Tropical Biomedicine》《Chinese Journal of Chemistry》《Synthetic and Systems Biotechnology》《Natural Products and Bioprospecting》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金中国科学院知识创新工程更多>>
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Evolution of the Short Enantioselective Total Synthesis of the Unique Marine Myxobacteria Polyketide Salimabromide
《Chinese Journal of Chemistry》2025年第1期79-89,共11页Kang-Ji Gan Yao Zhu Gaosheng Shi Changhui Wu Fu-Qiang Ni Li-Han Zhao Xiaowei Dou Zhihan Zhang Hai-Hua Lu 
Zhejiang Provincial Key Laboratory Construction Project and the National Natural Science Foundation of China(No.22271236)for support of this research.
Salimabromide,a unique and scarce marine tetracyclic polyketide,was synthesized in both racemic and optically active forms.A novel carboxylic acid-directed method for tandem oxidative difunctionalization of olefins wa...
关键词：Natural products Salimabromide Total synthesis Enantioselective catalysis CHIRALITY Radical cyclization Olefinfunctionalization Isotopeeffects 
Unveiling the Mechanisms of Apoptosis Induction by Deep-Sea-Derived Polyketide-Terpenoid Hybrids from Penicillium allii-sativi:A Focus on Mitochondrial and mTOR Pathways
《Chinese Journal of Chemistry》2024年第24期3283-3292,共10页Chun-Lan Xie Tai-Zong Wu Duo Zhang Yuan Wang Ting Lin Hai-Feng Chen Xiao-Kun Zhang Xian-Wen Yang 
supported by the National Key Research and Development Program of China(2022YFC2084103);Xiamen Southern Oceanographic Center(22GYY007HJ07);the National Natural Science Foundation of China(22177143).
A chemical investigation of the deep-sea-derived fungus Penicillium allii-sativi MCCC 3A00580 resulted in the discovery of four new meroterpenoids(1—4)and one related known co-metabolite(5).These meroterpenoids showc...
关键词：Deep-sea-derived fungus Penicillium allii-sativi MEROTERPENOIDS Drimane sesquiterpene Peroxide Mitochondrial apoptosis mTOR Cancer treatment TERPENOID Structure elucidation 
Genome mining of multi-substituted alkylresorcinols from a hybrid highly reducing-and typeⅢ-polyketide pathway
《Chinese Chemical Letters》2024年第7期345-349,共5页Huaran Zhang Yuting Huang Yingjie Tang Dekun Kong Yi Zou 
supported by the National Natural Science Foundation of China(No.22277100);the National Key R&D Program of China(No.2020YFA0907700);the Fundamental Research Funds for the Central Universities(Nos.SWU-KQ22034 and SWUXDPY22009);the Science and Technology Innovation Key R&D Program of Chongqing(No.CSTB2022TIAD-STX0015);the Chongqing Science Funds for Distinguished Young Scientists(No.cstc2020jcyj-jqX0005)。
Fungal alkylresorcinols are a class of polyketides,which are commonly synthesized by the hybridization of highly reducing polyketide synthase(hrPKS)with non-reducing polyketide synthase(nrPKS).In this study,we identif...
关键词：Genome mining Alkylresorcinol hrPKS TypeⅢPKS Iterative catalysis 
Rational Engineering of Secondary Metabolic Pathways in a Heterologous Host to Enable the Biosynthesis of Hibarimicin Derivatives with Enhanced Anti-Melanomic Activity
《Engineering》2024年第7期113-123,共11页Xiangyang Liu Fei-Peng Zhao Tian Tian Wei-Chen Wang Zaizhou Liu Qiang Zhou Xian-Feng Hou Jing Wang Wenli Guo Shuangjun Lin Yasuhiro Igarashi Gong-Li Tang 
supported in part by grants from the National Key Research and Development Program of China(2018YFA0901900);the National Natural Science Foundation of China(22137009);the China Postdoctoral Science Foundation(2020M671271).
A 61-kb biosynthetic gene cluster(BGC),which is accountable for the biosynthesis of hibarimicin(HBM)B from Microbispora rosea subsp.hibaria TP-A0121,was heterologously expressed in Streptomyces coelicolor M1154,which ...
关键词：Hibarimicin BIOSYNTHESIS Heterologous expression Biosynthetic gene cluster Rational engineering Type-II polyketide 
Talaroclauxins A and B:Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons from Talaromyces stipitatus
《Chinese Chemical Letters》2024年第1期300-304,共5页Qin Li Mi Zhang Xiaotian Zhang Lanqin Li Meijia Zheng Jinbing Kang Fei Liu Qun Zhou Xiaonian Li Weiguang Sun Junjun Liu Chunmei Chen Hucheng Zhu Yonghui Zhang 
the Program for Changjiang Scholars of Ministry of Education of the People's Republic of China(No.T2016088);the National Natural Science Foundation for Distinguished Young Scholars(No.81725021);the National Natural Science Foundation for Excellent Young Scholars(No.81922065);Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the National Natural Science Foundation of China(No.82173706);the Science and Technology Major Project of Hubei Province(No.2021ACA012);the Research and Development Program of Hubei Province(No.2020BCA058);the Academic Frontier Youth Team of HUST(No.2017QYTD19);the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College(HUST).
Talaroclauxins A and B(1 and 2),two novel duclauxin hybrids,were obtained from Talaromyces stipitatus,along with three new(3-5)and one known analogue(6).Their structures were determined by NMR spectroscopy,HRESIMS,sin...
关键词：Talaromyces stipitatus(Trichocomaceae) Duclauxin hybrids Single-crystal X-ray diffraction Biosynthetic pathways Neuroprotective effects 
Biosynthesis of trialkyl-substituted aromatic polyketide NFAT-133 involves unusual P450 monooxygenase-mediating aromatization and a putative metallo-beta-lactamase fold hydrolase
《Synthetic and Systems Biotechnology》2023年第3期349-356,共8页Ming Yang Wanlu Li Lin Zhou Xiao Lin Wenyu Zhang Yaoyao Shen Hai Deng Hou-wen Lin Yongjun Zhou 
the National Natural Science Foundation of China(Nos.32070070,32211530074 and 31929001);the innovative research team of high-level local universities in Shanghai.H.D.thanks Royal Society-NSFC international exchange grant(IEC\NSFC\211349).
The bacterial trialkyl-substituted aromatic polyketides are structurally featured with the unusual aromatic core in the middle of polyketide chain such as TM-123(1),veramycin A(2),NFAT-133(3)and benwamycin I(4),which ...
关键词：Thioesterase Metallo hydrolase METALLO-BETA-LACTAMASE Aromatic polyketide Polyketide synthase P450 monooxygenase 
Three previously undescribed metabolites from Cordyceps cicadae JXCH-1,an entomopathogenic fungus
《Natural Products and Bioprospecting》2023年第1期206-213,共8页Jing Fan Pai Liu Kuan Zhao He-Ping Chen 
the National Natural Science Foundation of China(grant number 81903512);the Fundamental Research Funds for the Central Universities,South-Central Minzu University(Grant Number CPT22033).
Three previously undescribed compounds,cordycicadione(1),cordycicadin F(2),and 7-hydroxybassiatin(3),were isolated from the cultures of Cordyceps cicadae JXCH1,an entomopathogenic fungus.Their structures and relative ...
关键词：Insect pathogenic fungus Cordyceps cicadae STEROID POLYKETIDE Cyclic dipeptide 
Biosynthesis of rumbrins and inspiration for discovery of HIV inhibitors被引量：2
《Acta Pharmaceutica Sinica B》2022年第11期4193-4203,共11页Beifen Zhong Jun Wan Changhui Shang Jiajia Wen Yujia Wang Jian Bai Shan Cen Youcai Hu 
supported financially by the National Key Research and Development Program of China(2018YFA0901900);the CAMS Innovation Fund for Medical Sciences (CIFMS, No. 2021-I2M-1-029, China)
Investigation on how nature produces natural compounds with chemical and biological diversity at the genetic level offers inspiration for the discovery of new natural products and even their biological targets.The pol...
关键词：Rumbrins POLYKETIDE Precursor-directed biosynthesis Resistance gene Anti-HIV activity 
Investigation of carbonyl amidation and O-methylation during biosynthesis of the pharmacophore pyridyl of antitumor piericidins被引量：2
《Synthetic and Systems Biotechnology》2022年第3期880-886,共7页Wanlu Li Wenyu Zhang Yijia Cheng Yaoyao Shen Jianzhao Qi Hou-Wen Lin Yongjun Zhou 
support from the National Natural Science Foundation of China(Nos.32070070,31929001,and 31800031);the Innovative Research Team of High-Level Local Universities in Shanghai。
Piericidins are a large family of bacterialα-pyridone antibiotics with antitumor activities such as their anti-renal carcinoma activity exhibited recently in nude mice.The backbones of piericidins are derived fromβ,...
关键词：POLYKETIDE Pyridine Polyketide synthase(PKS) Natural product biosynthesis 
Carbon-nitrogen bond formation to construct novel polyketide-indole hybrids from the indole-3-carbinol exposed culture of Daldinia eschscholzii
《Synthetic and Systems Biotechnology》2022年第2期750-755,共6页Li Ping Lin Min Wu Nan Jiang Wei Wang Ren Xiang Tan 
This work was co-financed by grants from the National Natural Science Foundation of China(NSFC)(82073721 and 81991524);National Key R&D Program of China(2018YFC1706205).
A plenty of cytochrome P450s have been annotated in the Daldinia eschosholzii genome.Inspired by the fact that some P450s have been reported to catalyze the carbon-nitrogen(C-N)bond formation,we were curious about whe...
关键词：Polyketide-indole hybrids Daldinia eschosholzii INDOLE-3-CARBINOL C-N bond formation P450 Precursor-directed biosynthesis 
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