METALLO-BETA-LACTAMASE

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相关领域：医药卫生更多>>
相关机构：首都医科大学附属北京儿童医院更多>>
相关期刊：《Advances in Microbiology》《Journal of Chinese Pharmaceutical Sciences》《Synthetic and Systems Biotechnology》更多>>
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Biosynthesis of trialkyl-substituted aromatic polyketide NFAT-133 involves unusual P450 monooxygenase-mediating aromatization and a putative metallo-beta-lactamase fold hydrolase
《Synthetic and Systems Biotechnology》2023年第3期349-356,共8页Ming Yang Wanlu Li Lin Zhou Xiao Lin Wenyu Zhang Yaoyao Shen Hai Deng Hou-wen Lin Yongjun Zhou 
the National Natural Science Foundation of China(Nos.32070070,32211530074 and 31929001);the innovative research team of high-level local universities in Shanghai.H.D.thanks Royal Society-NSFC international exchange grant(IEC\NSFC\211349).
The bacterial trialkyl-substituted aromatic polyketides are structurally featured with the unusual aromatic core in the middle of polyketide chain such as TM-123(1),veramycin A(2),NFAT-133(3)and benwamycin I(4),which ...
关键词：Thioesterase Metallo hydrolase METALLO-BETA-LACTAMASE Aromatic polyketide Polyketide synthase P450 monooxygenase 
Phenotypic and Genotypic Characterization of Metallo-Beta-Lactamase and Extended-Spectrum Beta-Lactamase among Enterobacteria Isolated at National Public Health Laboratory of Brazzaville
《Advances in Microbiology》2022年第6期363-377,共15页Nicole Prisca Makaya Dangui Nieko Cyr Jonas Morabandza Moїse Doria Kaya-Ongoto Duchel Jeanedvi Kinouani Kinavouidi Haman Judel Mikia Fabien Kangoula-Dia-Kikouidi-Kia-Louzala Fabien Roch Niama 
The improper use of antimicrobials against infectious diseases has allowed microorganisms to develop defense mechanisms that give them insensitivity to these agents. All bacteria are concerned by this phenomenon. This...
关键词：ENTEROBACTERIA Antibiotic Resistance Extended-Spectrum Beta-Lactamases Metallo-Beta-Lactamases bla Genes 
Virtual screening and high-throughput testing of L1 metallo-β-lactamase inhibitor
《Journal of Chinese Pharmaceutical Sciences》2021年第10期806-812,共7页Chennan Liu Qian Wang Jiangxue Han Sihan Liu Chunling Xiao Yan Guan Xinghua Li Ying Wang Xiao Wang Jianzhou Meng Maoluo Gan Yishuang Liu 
Natural Sciences Foundation of China (Grant No. 81872913);National High-tech R&D Program (863 Program, Grant No. 2015AA020911)。
As a zinc-dependent enzyme, metal-β-lactamase L1 contributes to the development of β-lactam antibiotic resistance. The metal-β-lactamase inhibitor can restore the efficacy of β-lactam antibiotics, and its developm...
关键词：L1 Metallo-beta-lactamase inhibitor Virtual screening High-throughput screening 
Detection of the Production of Klebsiella Pneumoniae Carbapenemase, New Delhi Metallo-Beta-Lactamase and Oxacillinase-48-Type Carbapenemases by Gram-Negative Bacilli in Resource-Limited Setting
《Advances in Microbiology》2021年第10期579-590,共12页Cecile Okalla Ebongue Gabin Gaël Simo Jean Pierre Nda Mefo’o Grace Dalle Ngondi Emmanuel Roddy Mengue Guy Pascal Ngaba Dieudonne Adiogo 
Background: The increasing resistance of bacteria to various antibiotics is a worldwide public health issue. Carbapenems that have elicited great hope in treating infections caused by multidrug-resistant germs ...
关键词：CARBAPENEMASES Gram-Negative Bacilli MULTIDRUG-RESISTANCE Cameroon 
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