Three previously undescribed metabolites from Cordyceps cicadae JXCH-1,an entomopathogenic fungus  

作　　者：Jing Fan Pai Liu Kuan Zhao He-Ping Chen 

机构地区：[1]School of Pharmaceutical Sciences,South-Central Minzu University,Wuhan 430074,China [2]School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China [3]College of Life Science,Jiangxi Science&Technology Normal University,Nanchang 330013,China

出　　处：《Natural Products and Bioprospecting》2023年第1期206-213,共8页应用天然产物（英文）

基　　金：the National Natural Science Foundation of China(grant number 81903512);the Fundamental Research Funds for the Central Universities,South-Central Minzu University(Grant Number CPT22033).

摘　　要：Three previously undescribed compounds,cordycicadione(1),cordycicadin F(2),and 7-hydroxybassiatin(3),were isolated from the cultures of Cordyceps cicadae JXCH1,an entomopathogenic fungus.Their structures and relative configurations were elucidated primarily by NMR spectroscopic analysis.The absolute configurations of 1 and 2 were determined by ECD calculations.Single-crystal X-ray diffraction method was adopted to determine the absolute configuration of 3.Compound 2 is a polycyclic polyketide with an unusual enol ether moiety and a spiro ring.The compounds obtained in this study were subjected to screening their inhibition against the proliferation of the human lung cancer cell line A549 and the production of nitric oxide in murine macrophages RAW264.7.

关 键 词：Insect pathogenic fungus Cordyceps cicadae STEROID POLYKETIDE Cyclic dipeptide 

分 类 号：O62[理学—有机化学]