INDOLE-3-CARBINOL

作品数:12被引量:11H指数:3
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相关领域:医药卫生更多>>
相关作者:刘凤娟更多>>
相关机构:广东医学院附属医院首都师范大学台北医学大学更多>>
相关期刊:《World Journal of Experimental Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关基金:国家自然科学基金河北省自然科学基金国家高技术研究发展计划更多>>
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Carbon-nitrogen bond formation to construct novel polyketide-indole hybrids from the indole-3-carbinol exposed culture of Daldinia eschscholzii
《Synthetic and Systems Biotechnology》2022年第2期750-755,共6页Li Ping Lin Min Wu Nan Jiang Wei Wang Ren Xiang Tan 
This work was co-financed by grants from the National Natural Science Foundation of China(NSFC)(82073721 and 81991524);National Key R&D Program of China(2018YFC1706205).
A plenty of cytochrome P450s have been annotated in the Daldinia eschosholzii genome.Inspired by the fact that some P450s have been reported to catalyze the carbon-nitrogen(C-N)bond formation,we were curious about whe...
关键词:Polyketide-indole hybrids Daldinia eschosholzii INDOLE-3-CARBINOL C-N bond formation P450 Precursor-directed biosynthesis 
Post-ingestion conversion of dietary indoles into anticancer agents
《National Science Review》2022年第4期123-133,共11页Li Ping Lin Dan Liu Jia Cheng Qian Liang Wu Quan Zhao Ren Xiang Tan 
supported by the National Natural Science Foundation of China (81991524 and 82073721);the National Key Research and Development Program of China(2018YFC1706200);the Jiangsu Provincial Natural Science Foundation (BK20180159)。
There are health benefits from consuming cruciferous vegetables that release indole-3-carbinol(I3 C), but the in vivo transformation of I3 C-related indoles remains underinvestigated. Here we detail the post-ingestion...
关键词:INDOLE-3-CARBINOL reaction flux derailing(RFD)approach 2-(indol-3-ylmethyl)-3 3′-diindolylmethane(LTr1) ANTICANCER Lactobacillus acidophilus 
Analysis of anticancer compound,indole-3-carbinol,in broccoli using a new ultrasound-assisted dispersive-filter extraction method based on poly(deep eutectic solvent)-graphene oxide nanocomposite
《Journal of Pharmaceutical Analysis》2022年第2期301-307,共7页Yanan Yuan Huanhuan Chen Yehong Han Fengxia Qiao Hongyuan Yan 
supported by the National Natural Science Foundation of China(Grant Nos.:82073605 and 81803287);the Natural Science Foundation of Hebei Province(Grant Nos.:B2018201270 and H2021201002);the Talent Engineering Training Foundation of Hebei Province(Grant No.:A201802002);the Research Project of Hebei Provincial Administration of Traditional Chinese Medicine(Grant No.:2021174);Post-graduate's Innovation Fund Project of Hebei University(Grant No.:HBU2021ss006);the Outstanding Doctoral Cultivation Project of Hebei University(Grant No.:YB201703).
Indole-3-carbinol(I3C),an important anticancer compound found in broccoli,has attracted considerable attention.The rapid extraction and accurate analysis of I3C in the pharmaceutical industry in broccoli is challengin...
关键词:INDOLE-3-CARBINOL BROCCOLI Poly(deep eutectic solvent)-graphene oxide Ultrasound-assisted dispersive-filter extraction Rapid analysis 
Immune and microRNA responses to Helicobacter muridarum infection and indole-3-carbinol during colitis被引量:1
《World Journal of Gastroenterology》2020年第32期4763-4785,共23页Rasha Raheem Alkarkoushi Yvonne Hui Abbas S Tavakoli Udai Singh Prakash Nagarkatti Mitzi Nagarkatti Ioulia Chatzistamou Marpe Bam Traci L Testerman 
Supported by the National Institutes of Health,No.P20GM103641.
BACKGROUND Indole-3-carbinol(I3C)and other aryl hydrocarbon receptor agonists are known to modulate the immune system and ameliorate various inflammatory and autoimmune diseases in animal models,including colitis indu...
关键词:Helicobacter muridarum MICRORNA IMMUNE T regulatory cell T helper 17 cell COLITIS CYTOKINE 
Cytotoxic and antibacterial polyketide-indole hybrids synthesized from indole-3-carbinol by Daldinia eschscholzii被引量:3
《Acta Pharmaceutica Sinica B》2019年第2期369-380,共12页Liping Lin Nan Jiang Huimin Wu Yaning Mei Jie Yang Renxiang Tan 
supported by the National Natural Science Foundation of China(Grant Nos.81530089,21661140001,21672101,and 81503232);National Key R&D Program of China(2018YFC1706200);the Drug Innovation Major Project(2018ZX09711-001-007-004,China)for generous support
Two skeletally undescribed polyketide-indole hybrids(PIHs), named indolchromins A and B,were generated from indole-3-carbinol(I3 C) in the fungal culture(Daldinia eschscholzii). The indolchromin structures were elucid...
关键词:Polyketide-indole HYBRIDS INDOLE-3-CARBINOL Daldinia eschscholzii 8-Amino-7-oxononanoate synthase Decarboxylative CLAISEN condensation ANTIBACTERIAL Anticancer 
Bioactive Alkaloids from Indole-3-carbinol Exposed Culture of Daldinia eschscholzii被引量:3
《Chinese Journal of Chemistry》2018年第8期749-753,共5页Li Ping Lina Ren Xiang Tan 
We thank the National Natural Science Foundation of China (Nos. 81530089, 81503232, 21672101, and 21661140001) and State Project for Essential Drug Research and Development (No. 2018ZX09711001-007-004) for generous support.
Two new and rare bioactive indoles named dalesindoloids A (1) and B (3), along with 3-(1H-indole-3ylmethyl)-2-oxindole (2), were characterized from the indole-3-carbinot (13C)-exposed culture of Daldinia esc...
关键词:indole alkaloids INDOLE-3-CARBINOL Daldinia eschscholzii ANTICANCER ANTIBACTERIAL 
Development and validation of a rapid UPLC/MS method for the simultaneous determination of I3C, DIM, and related metabolites and its application to pharmacokinetics studies
《Journal of Chinese Pharmaceutical Sciences》2016年第7期477-488,共12页Yury Gomez Hu Wang Ah-Ng Tony Kong 
R01 CA118947;R01 CA152826 from National Cancer Institute(NCI);R01AT007065 from the National Center for Complementary and Alternative Medicines(NCCAM);the Office of Dietary Supplements(ODS);the National Institute of Health Grant R01 CA073674
Indole-3-carbinol(I3C) and diindolylmethane(DIM) are naturally derived dietary phytochemicals with promising anti-cancer properties that have been demonstrated both in vitro and in vivo. Using reversed-phase ultra-per...
关键词:UPLC/MS INDOLE-3-CARBINOL DIINDOLYLMETHANE PHARMACOKINETICS SINGLE-DOSE administration SPRAGUE-DAWLEY Rats 
Multiple therapeutic and preventive effects of 3,3'-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia被引量:1
《The Journal of Biomedical Research》2014年第5期339-348,共10页William Weiben Zhang Zhenqing Feng Steven A Narad 
Cruciferous vegetables belong to the plant family that has flowers with four equal-sized petals in the pattern of a crucifer cross.These vegetables are an abundant source of dietary phytochemicals,including glucosinol...
关键词:cruciferous vegetables 3 3'-diindolylmethane(DIM) indole-3-carbinol(I3C) prostate cancer high grade prostatic intraepithelial neoplasia(HGPIN) 
Natural compounds as anticancer agents: Experimental evidence
《World Journal of Experimental Medicine》2012年第3期45-57,共13页Jiao Wang Yang-Fu Jiang 
Supported by National Natural Science Foundation of China,No.81001587
Cancer prevention research has drawn much attention worldwide. It is believed that some types of cancer can be prevented by following a healthy life style. Cancer chemoprevention by either natural or synthetic agents ...
关键词:Cancer CHEMOPREVENTION Natural agents (-)-Epigallocatechin-3-gallate RESVERATROL Curcumin VITAMIN D INDOLE-3-CARBINOL 
Effects of Indole-3-Carbinol and Flavonoids Administered Separately and in Combination on Nitric Oxide Production and iNOS Expression in Rats
《Chinese Medicine》2010年第1期5-17,共13页Evita Rostoka Larisa Baumane Sergejs Isajevs Aija Line Karina Silina Maija Dzintare Darja Svirina Jelena Sharipova Ivars Kalvinsh Nikolajs Sjakste 
Beneficial effects of natural compounds are often attributed to modulation of NO production;however effects produced by plant extracts do not correlate with effects of purified components. The goal of our work was to ...
关键词:NITRIC OXIDE BAICALEIN LUTEOLIN INDOLE-3-CARBINOL Quercetin INDUCIBLE NITRIC OXIDE Synthase 
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