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This work was co-financed by grants from the National Natural Science Foundation of China(NSFC)(82073721 and 81991524);National Key R&D Program of China(2018YFC1706205).
A plenty of cytochrome P450s have been annotated in the Daldinia eschosholzii genome.Inspired by the fact that some P450s have been reported to catalyze the carbon-nitrogen(C-N)bond formation,we were curious about whe...
supported by the National Natural Science Foundation of China (81991524 and 82073721);the National Key Research and Development Program of China(2018YFC1706200);the Jiangsu Provincial Natural Science Foundation (BK20180159)。
There are health benefits from consuming cruciferous vegetables that release indole-3-carbinol(I3 C), but the in vivo transformation of I3 C-related indoles remains underinvestigated. Here we detail the post-ingestion...
supported by the National Natural Science Foundation of China(Grant Nos.:82073605 and 81803287);the Natural Science Foundation of Hebei Province(Grant Nos.:B2018201270 and H2021201002);the Talent Engineering Training Foundation of Hebei Province(Grant No.:A201802002);the Research Project of Hebei Provincial Administration of Traditional Chinese Medicine(Grant No.:2021174);Post-graduate's Innovation Fund Project of Hebei University(Grant No.:HBU2021ss006);the Outstanding Doctoral Cultivation Project of Hebei University(Grant No.:YB201703).
Indole-3-carbinol(I3C),an important anticancer compound found in broccoli,has attracted considerable attention.The rapid extraction and accurate analysis of I3C in the pharmaceutical industry in broccoli is challengin...
Supported by the National Institutes of Health,No.P20GM103641.
BACKGROUND Indole-3-carbinol(I3C)and other aryl hydrocarbon receptor agonists are known to modulate the immune system and ameliorate various inflammatory and autoimmune diseases in animal models,including colitis indu...
supported by the National Natural Science Foundation of China(Grant Nos.81530089,21661140001,21672101,and 81503232);National Key R&D Program of China(2018YFC1706200);the Drug Innovation Major Project(2018ZX09711-001-007-004,China)for generous support
Two skeletally undescribed polyketide-indole hybrids(PIHs), named indolchromins A and B,were generated from indole-3-carbinol(I3 C) in the fungal culture(Daldinia eschscholzii). The indolchromin structures were elucid...
We thank the National Natural Science Foundation of China (Nos. 81530089, 81503232, 21672101, and 21661140001) and State Project for Essential Drug Research and Development (No. 2018ZX09711001-007-004) for generous support.
Two new and rare bioactive indoles named dalesindoloids A (1) and B (3), along with 3-(1H-indole-3ylmethyl)-2-oxindole (2), were characterized from the indole-3-carbinot (13C)-exposed culture of Daldinia esc...
R01 CA118947;R01 CA152826 from National Cancer Institute(NCI);R01AT007065 from the National Center for Complementary and Alternative Medicines(NCCAM);the Office of Dietary Supplements(ODS);the National Institute of Health Grant R01 CA073674
Indole-3-carbinol(I3C) and diindolylmethane(DIM) are naturally derived dietary phytochemicals with promising anti-cancer properties that have been demonstrated both in vitro and in vivo. Using reversed-phase ultra-per...
Cruciferous vegetables belong to the plant family that has flowers with four equal-sized petals in the pattern of a crucifer cross.These vegetables are an abundant source of dietary phytochemicals,including glucosinol...
Supported by National Natural Science Foundation of China,No.81001587
Cancer prevention research has drawn much attention worldwide. It is believed that some types of cancer can be prevented by following a healthy life style. Cancer chemoprevention by either natural or synthetic agents ...
Beneficial effects of natural compounds are often attributed to modulation of NO production;however effects produced by plant extracts do not correlate with effects of purified components. The goal of our work was to ...