Multiple therapeutic and preventive effects of 3,3'-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia  

作　　者：William Weiben Zhang Zhenqing Feng Steven A Narad 

机构地区：[1]Division of Urology,Sunnybrook Health Sciences Centre,Sunnybrook Research Institute,University of Toronto [2]Department of Pathology,Nanjing Medical University [3]Department of Public Health Sciences,Women's College Hospital,Women's College Research Institute,University of Toronto

出　　处：《The Journal of Biomedical Research》2014年第5期339-348,共10页生物医学研究杂志（英文版）

摘　　要：Cruciferous vegetables belong to the plant family that has flowers with four equal-sized petals in the pattern of a crucifer cross.These vegetables are an abundant source of dietary phytochemicals,including glucosinolates and their hydrolysis products such as indole-3-carbinol（I3C） and 3,3＇-diindolylmethane（DIM）.By 2013,the total number of natural glucosinolates that have been documented is estimated to be 132.Recently,cruciferous vegetable intake has garnered great interest for its multiple health benefits such as anticancer,antiviral infections,human sex hormone regulation,and its therapeutic and preventive effects on prostate cancer and high grade prostatic intraepithelial neoplasia（HGPIN）.DIM is a hydrolysis product of glucosinolates and has been used in various trials.This review is to provide an insight into the latest developments of DIM in treating or preventing both prostate cancer and HGPIN.Cruciferous vegetables belong to the plant family that has flowers with four equal-sized petals in the pattern of a crucifer cross.These vegetables are an abundant source of dietary phytochemicals,including glucosinolates and their hydrolysis products such as indole-3-carbinol（I3C） and 3,3＇-diindolylmethane（DIM）.By 2013,the total number of natural glucosinolates that have been documented is estimated to be 132.Recently,cruciferous vegetable intake has garnered great interest for its multiple health benefits such as anticancer,antiviral infections,human sex hormone regulation,and its therapeutic and preventive effects on prostate cancer and high grade prostatic intraepithelial neoplasia（HGPIN）.DIM is a hydrolysis product of glucosinolates and has been used in various trials.This review is to provide an insight into the latest developments of DIM in treating or preventing both prostate cancer and HGPIN.

关 键 词：cruciferous vegetables 3 3＇-diindolylmethane（DIM） indole-3-carbinol（I3C） prostate cancer high grade prostatic intraepithelial neoplasia（HGPIN） 

分 类 号：R737.25[医药卫生—肿瘤]